{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T10:49:06Z","timestamp":1785235746153,"version":"3.55.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2022CFB599"],"award-info":[{"award-number":["2022CFB599"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Diabetic nephropathy is a severe chronic complication characterized by cytotoxicity, inflammation, and fibrosis, ultimately leading to renal failure. This study systematically investigated the effects of the PARP1 inhibitor PJ-34 on high glucose\u2013induced cytotoxicity, inflammation, and fibrosis in HK-2 cells, as well as its improvement on neuropathic pain response and transforming growth factor \u03b2 (TGF\u03b2) expression in a type 1 diabetes mellitus diabetic nephropathy mouse model. Through cellular and animal experiments, we observed that PJ-34 significantly enhanced the proliferative capacity of cells damaged by high glucose, reduced apoptosis, and decreased the release of proinflammatory factors TGF\u03b1, interleukin-6, and interleukin-1\u03b2. In the type 1 diabetes mellitus nephropathy mouse model, the administration of PJ-34 substantially improved parameters of neuropathic pain, alleviated renal tissue damage, reduced indicators of renal functional impairment\u2013inhibited renal fibrosis, and reduced the key protein expression in the epithelial-mesenchymal transition process, acting through the regulation of the TGF\u03b2\/Smads signaling pathway. This study elucidated the mechanism of action of the PARP1 inhibitor PJ-34 as a potential therapeutic agent for diabetic nephropathy, offering a novel strategy for its treatment.<\/jats:p>","DOI":"10.1093\/jimmun\/vkae024","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T17:15:21Z","timestamp":1740244521000},"page":"304-315","source":"Crossref","is-referenced-by-count":4,"title":["Effects of PARP1 inhibitor PJ-34 on TGF\u03b1, IL-6, and IL-1\u03b2 levels in diabetic nephropathy"],"prefix":"10.1093","volume":"214","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1036-3864","authenticated-orcid":false,"given":"Jing","family":"Ke","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Central Hospital of Ezhou , Ezhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Thyroid and Breast Surgery, Central Hospital of 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