{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T04:06:11Z","timestamp":1748664371402,"version":"3.41.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100017668","name":"Key Research and Development Project of Anhui Province","doi-asserted-by":"publisher","award":["202104j07020042"],"award-info":[{"award-number":["202104j07020042"]}],"id":[{"id":"10.13039\/501100017668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2208085QH257","2208085MH260"],"award-info":[{"award-number":["2208085QH257","2208085MH260"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Research Project of Anhui Province in 2022","award":["AHWJ2022b057"],"award-info":[{"award-number":["AHWJ2022b057"]}]},{"name":"Clinical Key Specialty Construction Project of Anhui Province"},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["WK9110000166"],"award-info":[{"award-number":["WK9110000166"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In people living with human immunodeficiency virus (HIV, PLWH), the coronavirus disease 2019 (COVID-19) vaccine often results in a limited humoral immune response. While a reduced absolute CD4+ T cell count is a known factor, other determinants remain unclear. To investigate variables influencing the differential antibody response to the COVID-19 vaccine in PLWH, 43 HIV-1\/AIDS patients receiving antiretroviral therapy (ART) and 2 doses of the COVID-19 vaccine were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immunoglobulin G (IgG) levels and neutralizing antibody (NAb) titers. A retrospective analysis was also performed, examining immune reconstitution and epidemiological history, including annual CD4+ T-cell counts and the duration of HIV-1 infection. To further elucidate the role of CD4+ T cells in the antibody response to the COVID-19 vaccine, next-generation sequencing was used to analyze the T cell receptor (TCR) profiles of CD4+ T cells from twelve representative individuals. The results showed that the SARS-CoV-2-specific antibody response in PLWH was not solely determined by the current CD4+ T cell count, the progression of immune reconstitution and the TCR profile of CD4+ T cells also played significant roles. These findings provide critical insights into the multifaceted roles of CD4+ T cells in SARS-CoV-2-specific antibody responses in PLWH following COVID-19 vaccination.<\/jats:p>","DOI":"10.1093\/jimmun\/vkae040","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T05:08:02Z","timestamp":1744780082000},"page":"917-925","source":"Crossref","is-referenced-by-count":0,"title":["Impact of CD4+ T cell and TCR repertoires on SARS-CoV-2-Specific antibody responses in PLWH following COVID-19 vaccination"],"prefix":"10.1093","volume":"214","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4058-2725","authenticated-orcid":false,"given":"Chengchao","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Infectious Disease, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei, Anhui, 230001,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei, Anhui, 230001,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Health Inspection and Quarantine, School of Public Health, Anhui Medical University , Hefei, Anhui, 230032,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiamin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Health Inspection and Quarantine, School of Public Health, Anhui Medical University , Hefei, Anhui, 230032,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei, Anhui, 230001,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of HIV Prevention and Control, Fuyang Center for Disease Control and Prevention , Fuyang, Anhui,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of HIV Prevention and Control, Yingzhou District Center for Disease Control and Prevention , Fuyang, Anhui,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2674-3800","authenticated-orcid":false,"given":"Hongliang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei, Anhui, 230001,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Health Inspection and Quarantine, School of Public Health, Anhui Medical University , Hefei, Anhui, 230032,","place":["China"]},{"name":"Central Laboratory of HIV Molecular and Immunology, Anhui Provincial Center for Disease Control and Prevention , Hefei, Anhui,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei, Anhui, 230001,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3617-2037","authenticated-orcid":false,"given":"Yue","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei, Anhui, 230001,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"2025053003514957800_vkae040-B1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1056\/NEJMoa1105243","article-title":"Prevention of HIV-1 infection with early antiretroviral therapy","volume":"365","author":"Cohen","year":"2011","journal-title":"The New England Journal of Medicine"},{"key":"2025053003514957800_vkae040-B2","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1001\/jama.2013.278328","article-title":"Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples","volume":"310","author":"Anglemyer","year":"2013","journal-title":"JAMA"},{"key":"2025053003514957800_vkae040-B3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1001\/jama.280.1.72","article-title":"Recovery of the immune system with antiretroviral therapy: the end of 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