{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T22:50:56Z","timestamp":1774047056452,"version":"3.50.1"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL107380"],"award-info":[{"award-number":["HL107380"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL146479"],"award-info":[{"award-number":["HL146479"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Staphylococcus aureus is a commensal and opportunist pathogen of the upper respiratory tract. The recognition of pathogen-associated molecular patterns through pattern-recognition receptors is crucial for eliminating microorganisms such as S. aureus. DC-SIGN (CD209) is a pattern-recognition receptor that binds to a broad range of pathogens, promoting phagocytosis. Here we aimed to study the role of mouse homologues of DC-SIGN, CD209d\/e, in a methicillin-resistant S. aureus (MRSA) pulmonary infection model. CD209d\/e\u2212\/\u2212 and wild-type C57BL\/6 mice were infected with MRSA and inflammatory parameters were evaluated. CD209d\/e\u2212\/\u2212 mice had delayed bacterial burden and mortality together with increased frequency of neutrophils and decreased dendritic cells in the lung compared with control mice. iNOS+ macrophages, and regulatory T cell frequency were decreased in the lungs of CD209d\/e\u2212\/\u2212 mice. CD209d\/e\u2212\/\u2212 mice had increased levels of inflammatory cytokines in the lungs, but levels of IL-12p40 were decreased. MRSA reduced expression of interferon-\u03b3 and pattern-recognition receptors in CD209d\/e\u2212\/\u2212 mice. MRSA uptake by phagocytes was decreased in the lungs of CD209d\/e\u2212\/\u2212 versus control mice. CD209d\/e\u2212\/\u2212 bone marrow derived macrophages showed impaired MRSA uptake and killing. These data suggest that CD209d\/e are essential receptors to control inflammation by activating macrophages leading to MRSA uptake and killing.<\/jats:p>","DOI":"10.1093\/jimmun\/vkae061","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T23:50:17Z","timestamp":1742341817000},"page":"703-713","source":"Crossref","is-referenced-by-count":1,"title":["CD209d\/e are required for macrophage-mediated phagocytosis and activation during methicillin-resistant <i>Staphylococcus aureus<\/i> pulmonary host defense"],"prefix":"10.1093","volume":"214","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1291-060X","authenticated-orcid":false,"given":"Flavia","family":"Rago","sequence":"first","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Pediatrics, UPMC Children\u2019s Hospital of Pittsburgh , Pittsburgh, PA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Y","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Pediatrics, UPMC Children\u2019s Hospital of Pittsburgh , Pittsburgh, PA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A","family":"Marinelli","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Pediatrics, UPMC Children\u2019s Hospital of Pittsburgh , Pittsburgh, PA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6312-3946","authenticated-orcid":false,"given":"Leigh M","family":"Miller","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Pediatrics, UPMC Children\u2019s Hospital of Pittsburgh , Pittsburgh, PA,","place":["United States"]},{"name":"Program in Microbiology and Immunology, University of Pittsburgh , Pittsburgh, PA,","place":["United 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Medicine, Department of Pediatrics, UPMC Children\u2019s Hospital of Pittsburgh , Pittsburgh, PA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3385-4558","authenticated-orcid":false,"given":"Saran","family":"Kupul","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Pediatrics, UPMC Children\u2019s Hospital of Pittsburgh , Pittsburgh, PA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5151-6304","authenticated-orcid":false,"given":"Jay K","family":"Kolls","sequence":"additional","affiliation":[{"name":"Center for Translational Research in Infection & Inflammation, Tulane University School of Medicine , New Orleans, LA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radha","family":"Gopal","sequence":"additional","affiliation":[{"name":"Division of 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