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However, exacerbated stromal ERS\/UPR is associated with reproductive complications. Given the ability of dendritic cells (DCs) to sense stress signals and be conditioned by stromal cells, here we investigated the transmission of ERS (TERS) from stromal cells to monocytes and its impact on tolerogenic DCs conditioning. Blood monocytes were differentiated into DCs (rhGM-CSF+rhIL-4, 5\u2009d) in the presence or absence of conditioned media derived from either thapsigargin-treated (stressed) or nonstressed human endometrial stromal cell line. Soluble factors released by stressed stromal cells impaired CD1a+CD14\u2212 DC differentiation and induced a proinflammatory profile, increasing the CD86high cell population, COX-2 expression, and tumor necrosis factor (TNF)-\u03b1, interleukin (IL)-8 and IL-1\u03b2 secretion. Additionally, TERS was observed in these cultures, with increased expression of IRE1\u03b1, PERK, and ATF4. Even the splicing of the adaptive UPR marker XBP1 was increased though at low levels, its nuclear translocation was unchanged. These effects on spliced XBP1, coupled with a decreased GRP78\/BiP and heightened CHOP expression, suggest the triggering of terminal UPR over adaptive UPR, confirmed by the induction of lytic cell death in stressed cultures. Finally, exacerbated TERS negatively impacted trophoblast migration in a blastocyst-like spheroid in vitro model. These findings suggest that exacerbated stromal ERS can be transmitted to monocytes, altering their differentiation, immune profile, and viability, which could ultimately impair trophoblast migration.<\/jats:p>","DOI":"10.1093\/jimmun\/vkae065","type":"journal-article","created":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T17:53:49Z","timestamp":1742666029000},"page":"795-807","source":"Crossref","is-referenced-by-count":3,"title":["Exacerbated endoplasmic reticulum stress transmitted by endometrial stromal cells alters the conditioning of tolerogenic dendritic cells affecting trophoblast migration"],"prefix":"10.1093","volume":"214","author":[{"given":"Elizabeth","family":"Soczewski","sequence":"first","affiliation":[{"name":"Universidad de Buenos Aires (UBA), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN-CONICET) , Buenos Aires,","place":["Argentina"]},{"name":"Placenta Lab, Department of Obstetrics, Jena University Hospital , Jena,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Schafir","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires (UBA), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN-CONICET) , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1705-768X","authenticated-orcid":false,"given":"Lara","family":"Castagnola","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires (UBA), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN-CONICET) , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Materazzi","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires (UBA), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN-CONICET) , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires (UBA), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN-CONICET) , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4421-4363","authenticated-orcid":false,"given":"Agustina","family":"Marcial","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires (UBA), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN-CONICET) , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7508-0055","authenticated-orcid":false,"given":"Jessica","family":"Presa","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (UBA) , Buenos Aires,","place":["Argentina"]},{"name":"Instituto de Biolog\u00eda y Medicina Experimental, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0781-0140","authenticated-orcid":false,"given":"Flavia","family":"Saravia","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (UBA) , Buenos Aires,","place":["Argentina"]},{"name":"Instituto de Biolog\u00eda y Medicina Experimental, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Grasso","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires (UBA), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales 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