{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T02:24:26Z","timestamp":1785378266249,"version":"3.55.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"KAKENHI","doi-asserted-by":"publisher","award":["23K27426"],"award-info":[{"award-number":["23K27426"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Institute for Life and Medical Sciences"},{"DOI":"10.13039\/501100005683","name":"Kyoto University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005683","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Type 1 innate lymphoid cells (ILC1s) respond to infections and tumors by producing IFN-\u03b3. Although RAR-related orphan receptor \u03b1 (ROR\u03b1) is required for ILC2s and some ILC3s, its role in ILC1 development remains controversial. To investigate the role of ROR\u03b1 in ILC1s, we analyzed bone marrow (BM) chimeras of ROR\u03b1-deficient mice. ILC1s derived from ROR\u03b1-deficient BM cells were significantly reduced in various tissues, including the intestine, indicating a hematopoietic cell-intrinsic need for ROR\u03b1 in ILC1 development. Developmental stage\u2013specific ROR\u03b1-deficient mice showed a decrease in adult liver and BM IL-7R+ ILC1s and an increase in BM NK cells, whereas fetal liver ILC1s and adult liver IL-7R\u2212 ILC1s remained unchanged. Furthermore, ROR\u03b1 is primarily required for IL-7R+ precursor stages and partially affects small intestine ILC1 after differentiation. This study suggests that ROR\u03b1 promotes ILC1 differentiation while suppressing NK cell differentiation at the ILC precursor stage in the adult BM.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf001","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T14:46:24Z","timestamp":1741877184000},"page":"575-581","source":"Crossref","is-referenced-by-count":7,"title":["The transcription factor ROR\u03b1 is required for the development of type 1 innate lymphoid cells in adult bone marrow"],"prefix":"10.1093","volume":"214","author":[{"given":"Shinya","family":"Abe","sequence":"first","affiliation":[{"name":"Laboratory of Immune Regulation, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University , Kyoto,","place":["Japan"]},{"name":"Department of Homeostatic Medicine, Medical Research Laboratory, Institute for Integrated Research, Institute of Science Tokyo , 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