{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:48:04Z","timestamp":1792900084456,"version":"4.5.0"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT-2019-01617"],"award-info":[{"award-number":["PICT-2019-01617"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT-2020-03211"],"award-info":[{"award-number":["PICT-2020-03211"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT-2021-367"],"award-info":[{"award-number":["PICT-2021-367"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010253","name":"Secretar\u00eda de Ciencia y T\u00e9cnica, Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["20020220300133BA"],"award-info":[{"award-number":["20020220300133BA"]}],"id":[{"id":"10.13039\/501100010253","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Neutrophils are the first line of defense against pathogens, combating them by using several antimicrobial mechanisms. These cells display a remarkable plasticity that can be molded by the different environments that neutrophils confront to protect the host, therefore presenting diverse phenotypes. Actually, pro- and anti-inflammatory neutrophils populations (N1- and N2-like phenotypes) have been described in cancer and inflammatory disorders. However, the identification of N1\/N2 neutrophil subtypes in human intracellular bacterial diseases remains unexplored. Here, we characterized neutrophils from tuberculosis (TB) patients presenting distinct immunological status according to their disease severity. TB patients were classified as high or low responders (HR or LR) in accordance with their immunity against Mycobacterium tuberculosis (Mtb). Interestingly, by analyzing the phenotypic and functional characteristics of neutrophils from the two groups of TB patients we demonstrated that HR patient\u2019s neutrophils display a pro-inflammatory N1-like phenotype, whereas LR patient\u2019s neutrophils show an anti-inflammatory N2-like phenotype. Remarkably, whereas neutrophils from both groups of patients phagocytized MtbH37Rv strain equally, HR TB\u2019s neutrophils displayed a significantly increased ability to kill pathogenic Mtb as compared to neutrophils from LR TB patients that presented a diminished capacity of bacterial elimination. Together, our findings suggest the existence of different subtypes of neutrophils in TB patients according to their immune response to Mtb and disease severity, indicating that neutrophils might be promising targets for TB host-directed therapy.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf010","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T08:29:22Z","timestamp":1746692962000},"page":"1173-1186","source":"Crossref","is-referenced-by-count":10,"title":["Neutrophils from tuberculosis patients are polarized toward pro-inflammatory and anti-inflammatory phenotypes according to the disease severity"],"prefix":"10.1093","volume":"214","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7157-486X","authenticated-orcid":false,"given":"Mar\u00eda Paula","family":"Morelli","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires , Ciudad Aut\u00f3noma de Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9105-500X","authenticated-orcid":false,"given":"Candela","family":"Martin","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires , Ciudad Aut\u00f3noma de Buenos Aires,","place":["Argentina"]},{"name":"Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) , Ciudad Aut\u00f3noma de Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3505-8638","authenticated-orcid":false,"given":"Joaqu\u00edn Miguel","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille Luminy, INSERM, Centre National de la Recherche Scientifique (CNRS), Aix-Marseille Universit\u00e9, Parc Scientifique et Technologique de Luminy , Marseille,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7820-2169","authenticated-orcid":false,"given":"Federico","family":"Blanco","sequence":"additional","affiliation":[{"name":"Instituto de Agrobiotecnolog\u00eda y Biolog\u00eda Molecular, INTA-CONICET, N. Repetto & de los Reseros, Hurlingham (1686) , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8637-7180","authenticated-orcid":false,"given":"Fabiana","family":"Bigi","sequence":"additional","affiliation":[{"name":"Instituto de Agrobiotecnolog\u00eda y Biolog\u00eda Molecular, INTA-CONICET, N. Repetto & de los Reseros, Hurlingham (1686) , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Ciallella","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Tisioneumonolog\u00eda, Hospital F.J. Mu\u00f1iz , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Musella","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Tisioneumonolog\u00eda, Hospital F.J. Mu\u00f1iz , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Rodriguez Mieres","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Tisioneumonolog\u00eda, Hospital F.J. Mu\u00f1iz , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela C","family":"de Casado","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Tisioneumonolog\u00eda, Hospital F.J. Mu\u00f1iz , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7496-5492","authenticated-orcid":false,"given":"Domingo Juan","family":"Palmero","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Tisioneumonolog\u00eda, Hospital F.J. 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