{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:58:53Z","timestamp":1784163533546,"version":"3.55.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20366"],"award-info":[{"award-number":["U21A20366"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971491"],"award-info":[{"award-number":["81971491"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["222300420066"],"award-info":[{"award-number":["222300420066"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Program for Science & Technology Innovation Talents in Universities of Henan Province","award":["23HASTIT049"],"award-info":[{"award-number":["23HASTIT049"]}]},{"name":"Program for Science & Technology Innovation Talents in Universities of Henan Province","award":["D20036"],"award-info":[{"award-number":["D20036"]}]},{"DOI":"10.13039\/501100011841","name":"Xinxiang Medical University","doi-asserted-by":"publisher","award":["505248"],"award-info":[{"award-number":["505248"]}],"id":[{"id":"10.13039\/501100011841","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although the importance of the unique member of S100 EF-hand family, S100A10 in health and disease is well appreciated, a precise characterization of S100A10 expression still remains elusive. To this purpose, we generated a knock-in mouse line in which downstream of the coding sequence of the S100a10 gene was inserted IRES-mCherry-pA sequence. Interestingly, mCherry fluorescence was widely distributed in splenic myeloid and lymphoid cells, whereas neutrophils showed a negligible mCherry level. By taking advantage of these reporter mice, we found Ly6C+ monocytes expressed the highest levels of S100A10 and bound significantly more plasminogen compared with the other respective leukocyte subsets. Furthermore, we demonstrated that S100A10 was required for emigration of Ly6C+ monocytes from bone marrow by mainly affecting CCR2 cell surface presentation. S100a10\u2212\/\u2212 mice had fewer circulating Ly6C+ monocytes and, after challenged with thioglycolate, accumulated less CCR2+ monocytes in bone marrow. However, S100A10 was not necessary for efficient neutrophil recruitment from the blood to inflamed tissue. These findings provide evidence that S100A10 is critical for monocyte mobilization and suggest its differential regulatory roles for monocyte and neutrophil chemoattractants in leukocyte homeostasis. Thus, targeting the S100A10-CCR2 pathway may be an attractive approach to regulate inflammatory responses and infectious diseases.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf021","type":"journal-article","created":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T17:56:29Z","timestamp":1742666189000},"page":"1344-1357","source":"Crossref","is-referenced-by-count":3,"title":["Differential expression of S100A10 protein in leukocytes and its effects on monocyte emigration from bone marrow"],"prefix":"10.1093","volume":"214","author":[{"given":"Yuxin","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences, Xinjiang Medical University , Urumqi, Xinjiang,","place":["China"]},{"name":"Henan Key Laboratory of Immunology and Targeted Drugs, Xinxiang Medical University , Xinxiang, Henan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Immunology and Targeted Drugs, Xinxiang Medical University , Xinxiang, Henan,","place":["China"]},{"name":"Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Medical Technology, Xinxiang Medical University , Xinxiang, Henan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Lv","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Immunology and Targeted Drugs, Xinxiang Medical University , Xinxiang, Henan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingtao","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Xinjiang Medical University , Urumqi, Xinjiang,","place":["China"]},{"name":"Henan Key Laboratory of Immunology and Targeted Drugs, Xinxiang Medical University , Xinxiang, Henan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lichen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Genetic Regulators in the Immune System, School of Medical Technology, Xinxiang Medical University , Xinxiang, Henan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Tian","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Immunology and Targeted Drugs, Xinxiang Medical University , Xinxiang, Henan,","place":["China"]},{"name":"Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Medical Technology, Xinxiang Medical University , Xinxiang, Henan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohang","family":"Sheng","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Immunology and Targeted Drugs, Xinxiang Medical University , Xinxiang, Henan,","place":["China"]},{"name":"Department of Immunology, Xinxiang Medical University , Xinxiang, Henan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Immunology and Targeted Drugs, Xinxiang Medical University , Xinxiang, Henan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cun","family":"Guo","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Immunology and Targeted Drugs, Xinxiang Medical University , Xinxiang, Henan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Lu","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Immunology and Targeted Drugs, Xinxiang Medical University , Xinxiang, Henan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Third Affiliated Hospital of Xinxiang Medical University , Xinxiang, Henan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingmin","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of Xinxiang Medical University , Xinxiang, Henan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunwei","family":"Lou","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Immunology and Targeted Drugs, Xinxiang Medical University , Xinxiang, Henan,","place":["China"]},{"name":"Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Medical Technology, Xinxiang Medical University , Xinxiang, Henan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Xinjiang Medical University , Urumqi, Xinjiang,","place":["China"]},{"name":"Henan Key Laboratory of Immunology and Targeted Drugs, Xinxiang Medical University , Xinxiang, Henan,","place":["China"]},{"name":"Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Medical Technology, Xinxiang Medical University , Xinxiang, Henan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"2025063003521610700_vkaf021-B1","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nri3070","article-title":"Monocyte recruitment during infection and inflammation","volume":"11","author":"Shi","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"2025063003521610700_vkaf021-B2","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.immuni.2018.10.005","article-title":"Developmental and functional heterogeneity of monocytes","volume":"49","author":"Guilliams","year":"2018","journal-title":"Immunity"},{"key":"2025063003521610700_vkaf021-B3","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/978-1-0716-2887-4_25","article-title":"Analysis of monocyte recruitment during inflammation by intravital imaging","volume":"2608","author":"Gonzalez-Granado","year":"2023","journal-title":"Methods Mol Biol"},{"key":"2025063003521610700_vkaf021-B4","doi-asserted-by":"crossref","first-page":"916","DOI":"10.3390\/cells13110916","article-title":"Ly6C(hi) Monocytes are metabolically reprogrammed in the blood during Inflammatory stimulation and require intact oxPhos for chemotaxis and monocyte to macrophage differentiation","volume":"13","author":"Purvis","year":"2024","journal-title":"Cells-Basel"},{"key":"2025063003521610700_vkaf021-B5","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1172\/JCI29919","article-title":"Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites","volume":"117","author":"Tsou","year":"2007","journal-title":"J Clin Invest"},{"key":"2025063003521610700_vkaf021-B6","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1084\/jem.186.10.1757","article-title":"Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor","volume":"186","author":"Kurihara","year":"1997","journal-title":"J Exp Med"},{"key":"2025063003521610700_vkaf021-B7","doi-asserted-by":"crossref","first-page":"7958","DOI":"10.1073\/pnas.131207398","article-title":"Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis","volume":"98","author":"Peters","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025063003521610700_vkaf021-B8","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1172\/JCI119798","article-title":"Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice","volume":"100","author":"Boring","year":"1997","journal-title":"J Clin Invest"},{"key":"2025063003521610700_vkaf021-B9","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/29788","article-title":"Decreased lesion formation in CCR2-\/- mice reveals a role for chemokines in the initiation of atherosclerosis","volume":"394","author":"Boring","year":"1998","journal-title":"Nature"},{"key":"2025063003521610700_vkaf021-B10","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1084\/jem.192.7.1075","article-title":"Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2","volume":"192","author":"Izikson","year":"2000","journal-title":"J Exp Med"},{"key":"2025063003521610700_vkaf021-B11","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1002\/j.1460-2075.1985.tb04023.x","article-title":"The regulatory chain in the p36-kd substrate complex of viral tyrosine-specific protein kinases is related in sequence to the S-100 protein of glial cells","volume":"4","author":"Gerke","year":"1985","journal-title":"EMBO J"},{"key":"2025063003521610700_vkaf021-B12","doi-asserted-by":"crossref","first-page":"25577","DOI":"10.1074\/jbc.M301017200","article-title":"Phospholipid-associated annexin A2-S100A10 heterotetramer and its subunits: characterization of the interaction with tissue plasminogen activator, plasminogen, and plasmin","volume":"278","author":"MacLeod","year":"2003","journal-title":"J Biol Chem"},{"key":"2025063003521610700_vkaf021-B13","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.tips.2020.04.004","article-title":"Modulation of Ion Channels and Receptors by p11 (S100A10)","volume":"41","author":"Seo","year":"2020","journal-title":"Trends Pharmacol Sci"},{"key":"2025063003521610700_vkaf021-B14","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1073\/pnas.1621218114","article-title":"Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson's disease","volume":"114","author":"Green","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025063003521610700_vkaf021-B15","doi-asserted-by":"crossref","first-page":"17029","DOI":"10.1038\/srep17029","article-title":"Probable involvement of p11 with interferon alpha induced depression","volume":"6","author":"Guo","year":"2016","journal-title":"Sci Rep"},{"key":"2025063003521610700_vkaf021-B16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1053\/j.gastro.2006.11.020","article-title":"Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndrome","volume":"132","author":"Camilleri","year":"2007","journal-title":"Gastroenterology"},{"key":"2025063003521610700_vkaf021-B17","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1182\/blood-2005-07-2840","article-title":"Identification of the annexin A2 heterotetramer as a receptor for the plasmin-induced signaling in human peripheral monocytes","volume":"107","author":"Laumonnier","year":"2006","journal-title":"Blood"},{"key":"2025063003521610700_vkaf021-B18","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1182\/blood-2010-01-264754","article-title":"S100A10 regulates plasminogen-dependent macrophage invasion","volume":"116","author":"O'Connell","year":"2010","journal-title":"Blood"},{"key":"2025063003521610700_vkaf021-B19","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/s41423-019-0278-1","article-title":"Essential roles of S100A10 in Toll-like receptor signaling and immunity to infection","volume":"17","author":"Lou","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"2025063003521610700_vkaf021-B20","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s13059-016-1012-2","article-title":"Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR","volume":"17","author":"Haeussler","year":"2016","journal-title":"Genome Biol"},{"key":"2025063003521610700_vkaf021-B21","doi-asserted-by":"crossref","first-page":"dmm033852","DOI":"10.1242\/dmm.033852","article-title":"A severe atherosclerosis mouse model on the resistant NOD background","volume":"11","author":"Wang","year":"2018","journal-title":"Dis Model Mech"},{"key":"2025063003521610700_vkaf021-B22","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nprot.2017.153","article-title":"Easi-CRISPR for creating knock-in and conditional knockout mouse models using long ssDNA donors","volume":"13","author":"Miura","year":"2018","journal-title":"Nat Protoc"},{"key":"2025063003521610700_vkaf021-B23","doi-asserted-by":"crossref","first-page":"874","DOI":"10.4049\/jimmunol.2300291","article-title":"Epithelial TIPE1 protein guards against colitis by inhibiting TNF-\u03b1-mediated inflammation","volume":"211","author":"Lou","year":"2023","journal-title":"J Immunol"},{"key":"2025063003521610700_vkaf021-B24","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1158\/2326-6066.CIR-21-0666","article-title":"Tumor necrosis factor-\u03b1-induced protein 8-like 2 fosters tumor-associated microbiota to promote the development of colorectal cancer","volume":"10","author":"Lou","year":"2022","journal-title":"Cancer Immunol Res"},{"key":"2025063003521610700_vkaf021-B25","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.4049\/jimmunol.1901142","article-title":"The SCF\u03b2-TrCP) E3 ubiquitin ligase regulates immune receptor signaling by targeting the negative regulatory protein TIPE2","volume":"204","author":"Lou","year":"2020","journal-title":"J Immunol"},{"key":"2025063003521610700_vkaf021-B26","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.4049\/jimmunol.1700111","article-title":"Ku70 senses HTLV-1 DNA and modulates HTLV-1 replication","volume":"199","author":"Wang","year":"2017","journal-title":"J Immunol"},{"key":"2025063003521610700_vkaf021-B27","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/cne.24113","article-title":"Cell- and region-specific expression of depression-related protein p11 (S100a10) in the brain","volume":"525","author":"Milosevic","year":"2017","journal-title":"J Comp Neurol"},{"key":"2025063003521610700_vkaf021-B28","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/nmeth819","article-title":"A guide to choosing fluorescent proteins","volume":"2","author":"Shaner","year":"2005","journal-title":"Nat Methods"},{"key":"2025063003521610700_vkaf021-B29","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.immuni.2012.12.001","article-title":"Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis","volume":"38","author":"Yona","year":"2013","journal-title":"Immunity"},{"key":"2025063003521610700_vkaf021-B30","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1182\/blood-2008-07-170787","article-title":"CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival","volume":"113","author":"Landsman","year":"2009","journal-title":"Blood"},{"key":"2025063003521610700_vkaf021-B31","doi-asserted-by":"crossref","first-page":"5622","DOI":"10.1182\/blood-2011-03-344242","article-title":"Regulation of macrophage migration by a novel plasminogen receptor Plg-R KT","volume":"118","author":"Lighvani","year":"2011","journal-title":"Blood"},{"key":"2025063003521610700_vkaf021-B32","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1182\/blood-2014-09-600833","article-title":"IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production","volume":"125","author":"Y\u00e1\u00f1ez","year":"2015","journal-title":"Blood"},{"key":"2025063003521610700_vkaf021-B33","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ni1309","article-title":"Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2","volume":"7","author":"Serbina","year":"2006","journal-title":"Nat Immunol"},{"key":"2025063003521610700_vkaf021-B34","doi-asserted-by":"crossref","first-page":"771210","DOI":"10.3389\/fimmu.2021.771210","article-title":"Targeting the CCL2\/CCR2 axis in cancer immunotherapy: one Stone, three Birds?","volume":"12","author":"Fei","year":"2021","journal-title":"Front Immunol"},{"key":"2025063003521610700_vkaf021-B35","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1016\/j.immuni.2021.10.007","article-title":"Resident macrophage-dependent immune cell scaffolds drive anti-bacterial defense in the peritoneal cavity","volume":"54","author":"Vega-P\u00e9rez","year":"2021","journal-title":"Immunity"},{"key":"2025063003521610700_vkaf021-B36","doi-asserted-by":"crossref","first-page":"10828","DOI":"10.1038\/ncomms10828","article-title":"Protection from septic peritonitis by rapid neutrophil recruitment through omental high endothelial venules","volume":"7","author":"Buscher","year":"2016","journal-title":"Nat Commun"},{"key":"2025063003521610700_vkaf021-B37","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00281-014-0418-8","article-title":"The multiple faces of leukocyte interstitial migration","volume":"36","author":"L\u00e4mmermann","year":"2014","journal-title":"Semin Immunopathol"},{"key":"2025063003521610700_vkaf021-B38","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/ni.f.212","article-title":"Interstitial leukocyte migration and immune function","volume":"9","author":"Friedl","year":"2008","journal-title":"Nat Immunol"},{"key":"2025063003521610700_vkaf021-B39","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.tcb.2020.06.007","article-title":"Principles of Leukocyte Migration Strategies","volume":"30","author":"Kameritsch","year":"2020","journal-title":"Trends Cell Biol"},{"key":"2025063003521610700_vkaf021-B40","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1093\/emboj\/cdg162","article-title":"Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex","volume":"22","author":"van de Graaf","year":"2003","journal-title":"EMBO J"},{"key":"2025063003521610700_vkaf021-B41","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nature00781","article-title":"Annexin II light chain regulates sensory neuron-specific sodium channel expression","volume":"417","author":"Okuse","year":"2002","journal-title":"Nature"},{"key":"2025063003521610700_vkaf021-B42","doi-asserted-by":"crossref","first-page":"38666","DOI":"10.1074\/jbc.M505981200","article-title":"Annexin II light chain p11 promotes functional expression of acid-sensing ion channel ASIC1a","volume":"280","author":"Donier","year":"2005","journal-title":"J Biol Chem"},{"key":"2025063003521610700_vkaf021-B43","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1126\/science.1117571","article-title":"Alterations in 5-HT1B receptor function by p11 in depression-like states","volume":"311","author":"Svenningsson","year":"2006","journal-title":"Science"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/214\/6\/1344\/62494812\/vkaf021.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/214\/6\/1344\/62494812\/vkaf021.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T07:52:30Z","timestamp":1751269950000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/214\/6\/1344\/8088357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,20]]},"references-count":43,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,3,20]]},"published-print":{"date-parts":[[2025,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jimmun\/vkaf021","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,6]]},"published":{"date-parts":[[2025,3,20]]}}}