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Consequently, there is potential utility in the treatment of a number of pathological conditions via being able to modify IFN-\u03b3 secretion. T cells and natural killer (NK) cells are the primary IFN-\u03b3 sources, with metabolic rewiring prior to their activation and IFN-\u03b3 secretion in both a unifying feature. The mechanisms by which metabolic changes, particularly increased glycolysis, drive enhanced IFN-\u03b3 production are multi-faceted, but are likely focused on epigenetic changes via increased acetyl CoA levels which fuels histone acetylation. Herein, we discuss the mechanisms by which metabolic changes drive altered IFN-\u03b3 synthesis by immune cells.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf045","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:12:34Z","timestamp":1743725554000},"page":"1105-1112","source":"Crossref","is-referenced-by-count":4,"title":["The metabolic drivers of IFN-\u03b3 release: glycolysis and acetyl CoA ride in the front seat"],"prefix":"10.1093","volume":"214","author":[{"given":"John","family":"Henderson","sequence":"first","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen , Copenhagen,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7483-740X","authenticated-orcid":false,"given":"Steven","family":"O\u2019Reilly","sequence":"additional","affiliation":[{"name":"Department of Bioscience, Durham University , Durham,","place":["United 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