{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T17:46:04Z","timestamp":1770227164107,"version":"3.49.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL119501"],"award-info":[{"award-number":["HL119501"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"OMRF Patricia and Don Capra Predoctoral Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Lung-resident conventional dendritic cells (cDCs) coordinate immune responses to respiratory viruses in the respiratory tract or after migration to mediastinal lymph nodes (mLN). Migratory DCs include cDC1s (CD103+XCR1+CD24hi) expressing IRF8 or cDC2s (CD11b+SIRP\u03b1+CD24+) expressing IRF4. IRF4+ cDC2s are divided into a CD24hi subset that requires IRF4 for differentiation and a CD24int subset that is present in the absence of IRF4. During influenza A virus (IAV) infection of mice, we characterized the kinetics of cDC2 subset accumulation in the lung and mLN and their differences in IRF4-dependent gene expression and function. We found that the 2 IRF4-expressing cDC2 subsets upregulated CD86 to high levels, produced IL-12p40 and the chemokines CCL17 and CCL22, and were capable of acquiring antigen in vivo and activating antigen-specific CD8+ T cells. Notably, the CD11b+CD24int cDC2 subset expressed canonical cDC markers and transcription factors and expanded to high numbers in the lung and mLN by d 6 postinfection. Transcriptome analyses on d 5 postinfection revealed that the CD11b+CD24int cDC2 subset expressed both IRF4 and IRF8 and harbored an elevated IFN response signature compared to the CD11b+CD24hi subset. Analyses of mice lacking Irf4 in CD11c+ cells showed that IRF4 promoted the function of CD11b+CD24int cDC2s, including the capacity to migrate to mLN and to produce CCL17 and CCL22, consistent with their altered gene expression profile in the absence of IRF4. In sum, our data show that the 2 lung-resident CD11b+ cDC2 subsets present in na\u00efve mice elaborated distinct and common functional responses regulated by IRF4 during IAV infection.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf060","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T19:34:31Z","timestamp":1744313671000},"page":"1032-1045","source":"Crossref","is-referenced-by-count":2,"title":["IRF4-regulated transcriptional and functional heterogeneity of lung-resident CD11b+ cDC2 subsets during influenza virus infection"],"prefix":"10.1093","volume":"214","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5629-9131","authenticated-orcid":false,"given":"Ibrahim","family":"Hatipoglu","sequence":"first","affiliation":[{"name":"Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation , Oklahoma City, OK,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erola","family":"Ainsua-Enrich","sequence":"additional","affiliation":[{"name":"Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation , Oklahoma City, OK,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sapana","family":"Kadel","sequence":"additional","affiliation":[{"name":"Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation , Oklahoma City, OK,","place":["United States"]},{"name":"Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center , Oklahoma City, OK,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9879-0183","authenticated-orcid":false,"given":"Sean","family":"Turner","sequence":"additional","affiliation":[{"name":"Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation , Oklahoma City, OK,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simar","family":"Singh","sequence":"additional","affiliation":[{"name":"Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation , Oklahoma City, OK,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5479-9952","authenticated-orcid":false,"given":"Susan","family":"Kovats","sequence":"additional","affiliation":[{"name":"Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation , Oklahoma City, OK,","place":["United States"]},{"name":"Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center , Oklahoma City, OK,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"2025053003520054600_vkaf060-B1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nri3166","article-title":"Regulating the adaptive immune response to respiratory virus infection","volume":"12","author":"Braciale","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"2025053003520054600_vkaf060-B2","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/mi.2014.133","article-title":"Antibody-targeted vaccination to lung dendritic cells generates tissue-resident memory CD8 T cells that are highly protective against influenza virus infection","volume":"8","author":"Wakim","year":"2015","journal-title":"Mucosal Immunol"},{"key":"2025053003520054600_vkaf060-B3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41551-024-01208-4","article-title":"Dendritic-cell-targeting virus-like particles as potent mRNA vaccine carriers","volume":"9","author":"Yin","year":"2025","journal-title":"Nat Biomed Eng"},{"key":"2025053003520054600_vkaf060-B4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev-immunol-032713-120204","article-title":"Transcriptional control of dendritic cell development","volume":"34","author":"Murphy","year":"2016","journal-title":"Annu Rev Immunol"},{"key":"2025053003520054600_vkaf060-B5","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/mi.2017.8","article-title":"Development of conventional dendritic cells: from common bone marrow progenitors to multiple subsets in peripheral tissues","volume":"10","author":"Sichien","year":"2017","journal-title":"Mucosal Immunol"},{"key":"2025053003520054600_vkaf060-B6","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.4049\/jimmunol.1501870","article-title":"IRF4 and IRF8 act in CD11c+ cells to regulate terminal differentiation of lung tissue dendritic cells","volume":"196","author":"Baja\u00f1a","year":"2016","journal-title":"J Immunol"},{"key":"2025053003520054600_vkaf060-B7","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.immuni.2011.08.013","article-title":"Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine","volume":"35","author":"Lewis","year":"2011","journal-title":"Immunity"},{"key":"2025053003520054600_vkaf060-B8","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/ni.2679","article-title":"Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens","volume":"14","author":"Satpathy","year":"2013","journal-title":"Nat Immunol"},{"key":"2025053003520054600_vkaf060-B9","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.immuni.2015.04.017","article-title":"Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses","volume":"42","author":"Tussiwand","year":"2015","journal-title":"Immunity"},{"key":"2025053003520054600_vkaf060-B10","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.cell.2019.09.035","article-title":"Transcriptional basis of mouse and human dendritic cell heterogeneity","volume":"179","author":"Brown","year":"2019","journal-title":"Cell"},{"key":"2025053003520054600_vkaf060-B11","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.immuni.2020.04.005","article-title":"Inflammatory type 2 cDCs acquire features of cDC1s and macrophages to orchestrate immunity to respiratory virus infection","volume":"52","author":"Bosteels","year":"2020","journal-title":"Immunity"},{"key":"2025053003520054600_vkaf060-B12","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/s41385-019-0173-1","article-title":"IRF4-dependent dendritic cells regulate CD8+ T-cell differentiation and memory responses in influenza infection","volume":"12","author":"Ainsua-Enrich","year":"2019","journal-title":"Mucosal Immunol"},{"key":"2025053003520054600_vkaf060-B13","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1038\/ncomms3990","article-title":"Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation","volume":"4","author":"Williams","year":"2013","journal-title":"Nat Commun"},{"key":"2025053003520054600_vkaf060-B14","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.immuni.2013.04.011","article-title":"IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses","volume":"38","author":"Schlitzer","year":"2013","journal-title":"Immunity"},{"key":"2025053003520054600_vkaf060-B15","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.immuni.2013.03.009","article-title":"IRF4 transcription-factor-dependent CD103(+)CD11b(+) dendritic cells drive mucosal T helper 17 cell differentiation","volume":"38","author":"Persson","year":"2013","journal-title":"Immunity"},{"key":"2025053003520054600_vkaf060-B16","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.immuni.2013.08.028","article-title":"Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells","volume":"39","author":"Gao","year":"2013","journal-title":"Immunity"},{"key":"2025053003520054600_vkaf060-B17","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.4049\/jimmunol.1102613","article-title":"IRF4 promotes cutaneous dendritic cell migration to lymph nodes during homeostasis and inflammation","volume":"189","author":"Bajana","year":"2012","journal-title":"J Immunol"},{"key":"2025053003520054600_vkaf060-B18","doi-asserted-by":"crossref","first-page":"e140384","DOI":"10.1172\/jci.insight.140384","article-title":"IRF4 expression by lung dendritic cells drives acute but not Trm cell-dependent memory Th2 responses","volume":"7","author":"Camacho","year":"2022","journal-title":"JCI Insight"},{"key":"2025053003520054600_vkaf060-B19","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.4049\/jimmunol.1801549","article-title":"GM-CSF- and IRF4-dependent signaling can regulate myeloid cell numbers and the macrophage phenotype during inflammation","volume":"202","author":"Lee","year":"2019","journal-title":"J Immunol"},{"key":"2025053003520054600_vkaf060-B20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/ni.3294","article-title":"Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses","volume":"17","author":"Halim","year":"2016","journal-title":"Nat Immunol"},{"key":"2025053003520054600_vkaf060-B21","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1172\/JCI87828","article-title":"Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation","volume":"126","author":"Achuthan","year":"2016","journal-title":"J Clin Invest"},{"key":"2025053003520054600_vkaf060-B22","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1111\/all.15184","article-title":"The Ccl17 gene encoding TARC is synergistically transactivated by PU.1 and IRF4 driven by the mammalian common promoter in dendritic cells","volume":"77","author":"Ito","year":"2022","journal-title":"Allergy"},{"key":"2025053003520054600_vkaf060-B23","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/s41598-018-37894-9","article-title":"A transcription factor PU.1 is critical for Ccl22 gene expression in dendritic cells and macrophages","volume":"9","author":"Yashiro","year":"2019","journal-title":"Sci Rep"},{"key":"2025053003520054600_vkaf060-B24","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.immuni.2014.02.004","article-title":"Distinct dendritic cell subsets dictate the fate decision between effector and memory CD8(+) T cell differentiation by a CD24-dependent mechanism","volume":"40","author":"Kim","year":"2014","journal-title":"Immunity"},{"key":"2025053003520054600_vkaf060-B25","doi-asserted-by":"crossref","first-page":"113299","DOI":"10.1016\/j.celrep.2023.113299","article-title":"Lung cDC1 and cDC2 dendritic cells priming naive CD8+ T cells in situ prior to migration to draining lymph nodes","volume":"42","author":"Si","year":"2023","journal-title":"Cell Rep"},{"key":"2025053003520054600_vkaf060-B26","doi-asserted-by":"crossref","first-page":"3808","DOI":"10.4049\/jimmunol.1402195","article-title":"Complement receptor C5aR1\/CD88 and dipeptidyl peptidase-4\/CD26 define distinct hematopoietic lineages of dendritic cells","volume":"194","author":"Nakano","year":"2015","journal-title":"J Immunol"},{"key":"2025053003520054600_vkaf060-B27","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/ni1357","article-title":"Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination","volume":"7","author":"Klein","year":"2006","journal-title":"Nat Immunol"},{"key":"2025053003520054600_vkaf060-B28","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1084\/jem.20062648","article-title":"Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen","volume":"204","author":"Caton","year":"2007","journal-title":"J Exp Med"},{"key":"2025053003520054600_vkaf060-B29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-1-62703-496-8_2","article-title":"Pulmonary antigen presenting cells: isolation, purification, and culture","volume":"1032","author":"Nakano","year":"2013","journal-title":"Methods Mol Biol"},{"key":"2025053003520054600_vkaf060-B30","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1084\/jem.20120030","article-title":"Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages","volume":"209","author":"Satpathy","year":"2012","journal-title":"J Exp Med"},{"key":"2025053003520054600_vkaf060-B31","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1084\/jem.20112675","article-title":"Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage","volume":"209","author":"Meredith","year":"2012","journal-title":"J Exp Med"},{"key":"2025053003520054600_vkaf060-B32","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.4049\/jimmunol.176.4.2161","article-title":"A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins","volume":"176","author":"Sung","year":"2006","journal-title":"J Immunol"},{"key":"2025053003520054600_vkaf060-B33","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/ni.2419","article-title":"Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages","volume":"13","author":"Gautier","year":"2012","journal-title":"Nat Immunol"},{"key":"2025053003520054600_vkaf060-B34","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1165\/rcmb.2013-0086MA","article-title":"Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung","volume":"49","author":"Misharin","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2025053003520054600_vkaf060-B35","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.immuni.2012.10.016","article-title":"Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen","volume":"38","author":"Plantinga","year":"2013","journal-title":"Immunity"},{"key":"2025053003520054600_vkaf060-B36","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.jaci.2009.07.021","article-title":"Selective control of SIRP-alpha-positive airway dendritic cell trafficking through CD47 is critical for the development of T(H)2-mediated allergic inflammation","volume":"124","author":"Raymond","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"2025053003520054600_vkaf060-B37","doi-asserted-by":"crossref","first-page":"e85722","DOI":"10.7554\/eLife.85722","article-title":"Phantasus, a web application for visual and interactive gene expression analysis","volume":"13","author":"Kleverov","year":"2024","journal-title":"Elife"},{"key":"2025053003520054600_vkaf060-B38","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/ni.2370","article-title":"Deciphering the transcriptional network of the dendritic cell lineage","volume":"13","author":"Miller","year":"2012","journal-title":"Nat Immunol"},{"key":"2025053003520054600_vkaf060-B39","doi-asserted-by":"crossref","first-page":"108337","DOI":"10.1016\/j.celrep.2020.108337","article-title":"Human and mouse transcriptome profiling identifies cross-species homology in pulmonary and lymph node mononuclear phagocytes","volume":"33","author":"Leach","year":"2020","journal-title":"Cell Rep"},{"key":"2025053003520054600_vkaf060-B40","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/eji.201141846","article-title":"CISH is induced during DC development and regulates DC-mediated CTL activation","volume":"42","author":"Miah","year":"2012","journal-title":"Eur J Immunol"},{"key":"2025053003520054600_vkaf060-B41","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1128\/MCB.00974-10","article-title":"Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity","volume":"31","author":"Carneiro","year":"2011","journal-title":"Mol Cell Biol"},{"key":"2025053003520054600_vkaf060-B42","doi-asserted-by":"crossref","first-page":"jem.20190449","DOI":"10.1084\/jem.20190449","article-title":"The transcription factor NFAT5 limits infection-induced type I interferon responses","volume":"217","author":"Huerga Encabo","year":"2020","journal-title":"J Exp Med"},{"key":"2025053003520054600_vkaf060-B43","doi-asserted-by":"crossref","first-page":"12100","DOI":"10.1096\/fj.202000864R","article-title":"CITED2 limits pathogenic inflammatory gene programs in myeloid cells","volume":"34","author":"Pong Ng","year":"2020","journal-title":"FASEB J"},{"key":"2025053003520054600_vkaf060-B44","doi-asserted-by":"crossref","first-page":"L602","DOI":"10.1152\/ajplung.00444.2016","article-title":"The metalloproteinase ADAM8 promotes leukocyte recruitment in vitro and in acute lung inflammation","volume":"313","author":"Dreymueller","year":"2017","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2025053003520054600_vkaf060-B45","doi-asserted-by":"crossref","first-page":"8736","DOI":"10.1073\/pnas.0906126107","article-title":"Requirement of CCL17 for CCR7- and CXCR4-dependent migration of cutaneous dendritic cells","volume":"107","author":"Stutte","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025053003520054600_vkaf060-B46","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/eji.201847671","article-title":"Expression of Plet1 controls interstitial migration of murine small intestinal dendritic cells","volume":"49","author":"Karrich","year":"2019","journal-title":"Eur J Immunol"},{"key":"2025053003520054600_vkaf060-B47","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1002\/eji.201545897","article-title":"Monocyte infiltration into obese and fibrilized tissues is regulated by PILR\u03b1","volume":"46","author":"Kohyama","year":"2016","journal-title":"Eur J Immunol"},{"key":"2025053003520054600_vkaf060-B48","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nri.2016.78","article-title":"Discriminating self from non-self in nucleic acid sensing","volume":"16","author":"Schlee","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"2025053003520054600_vkaf060-B49","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/s41590-024-01745-9","article-title":"Distinct ontogenetic lineages dictate cDC2 heterogeneity","volume":"25","author":"Minutti","year":"2024","journal-title":"Nat Immunol"},{"key":"2025053003520054600_vkaf060-B50","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.immuni.2021.10.020","article-title":"Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity","volume":"55","author":"Duong","year":"2022","journal-title":"Immunity"},{"key":"2025053003520054600_vkaf060-B51","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1084\/jem.20130091","article-title":"Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4","volume":"210","author":"Mikhak","year":"2013","journal-title":"J Exp Med"},{"key":"2025053003520054600_vkaf060-B52","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jaci.2008.09.049","article-title":"Contribution of CCR4 and CCR8 to antigen-specific T(H)2 cell trafficking in allergic pulmonary inflammation","volume":"123","author":"Mikhak","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"2025053003520054600_vkaf060-B53","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.3390\/ijms18112306","article-title":"The C-C chemokines CCL17 and CCL22 and their receptor CCR4 in CNS autoimmunity","volume":"18","author":"Scheu","year":"2017","journal-title":"Int J Mol Sci"},{"key":"2025053003520054600_vkaf060-B54","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/ni.1848","article-title":"Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs","volume":"11","author":"Semmling","year":"2010","journal-title":"Nat Immunol"},{"key":"2025053003520054600_vkaf060-B55","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1084\/jem.20170277","article-title":"CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodes","volume":"216","author":"Rapp","year":"2019","journal-title":"J Exp Med"},{"key":"2025053003520054600_vkaf060-B56","doi-asserted-by":"crossref","first-page":"25816","DOI":"10.1073\/pnas.1913491116","article-title":"Cross-talk between iNKT cells and CD8 T cells in the spleen requires the IL-4\/CCL17 axis for the generation of short-lived effector cells","volume":"116","author":"Valente","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025053003520054600_vkaf060-B57","doi-asserted-by":"crossref","first-page":"eabl6322","DOI":"10.1126\/sciimmunol.abl6322","article-title":"Intrinsic IL-2 production by effector CD8 T cells affects IL-2 signaling and promotes fate decisions, stemness, and protection","volume":"7","author":"Kahan","year":"2022","journal-title":"Sci Immunol"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/214\/5\/1032\/62906936\/vkaf060.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/214\/5\/1032\/62906936\/vkaf060.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T07:52:18Z","timestamp":1748591538000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/214\/5\/1032\/8110507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,10]]},"references-count":57,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jimmun\/vkaf060","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,5]]},"published":{"date-parts":[[2025,4,10]]}}}