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However, their functional behavior, phenotypic stability, and suppressive properties upon antigen re-exposure remain poorly understood. Emerging evidence suggests that mTregs exhibit enhanced proliferation and suppressive capacity upon re-encountering the same antigen, a feature that may be critical in recurrent infections such as malaria. In malaria, Tregs are known to modulate immune responses and influence acute disease outcomes, suggesting that mTreg recall may play a significant role in long-term immunity. This review explores the biology of Treg memory, with a focus on malaria, and examines the immunological implications of maintaining a suppressive mTreg population in malaria immunity.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf067","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:10:22Z","timestamp":1745424622000},"page":"1872-1880","source":"Crossref","is-referenced-by-count":2,"title":["Regulatory T cell memory: implications for malaria"],"prefix":"10.1093","volume":"214","author":[{"given":"Nana Appiah Essel","family":"Charles-Chess","sequence":"first","affiliation":[{"name":"Department of Cellular Biology, University of Georgia , Athens, GA,","place":["United States"]},{"name":"Center for Tropical & Emerging Global Diseases, University of Georgia , Athens, GA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samarchith P","family":"Kurup","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology, University of Georgia , Athens, GA,","place":["United States"]},{"name":"Center for Tropical & Emerging Global Diseases, University of Georgia , Athens, GA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"2025082903515550100_vkaf067-B1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ni904","article-title":"Foxp3 programs the development and function of CD4+CD25+ regulatory T cells","volume":"4","author":"Fontenot","year":"2003","journal-title":"Nat Immunol"},{"key":"2025082903515550100_vkaf067-B2","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor 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