{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:26:34Z","timestamp":1785882394435,"version":"3.56.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Institute of Health"},{"name":"National Institute of Aging","award":["R21 AG075229"],"award-info":[{"award-number":["R21 AG075229"]}]},{"name":"Master of Science in Medical Biotechnology"},{"name":"University of Illinois College of Medicine Rockford"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We have designed the first antigen-less pro-vaccine, named 8206, for treating autoimmune diseases. Composed of dexamethasone, rapamycin, and R848 at a mass ratio of 8:20:6, 8206 is a complete tolerogenic adjuvant that acts systemically to form an active vaccine in situ with endogenous pathogenic autoantigens. This active vaccine suppresses autoimmunity by expanding antigen-specific Treg cells in affected tissues. In a mouse model of atherosclerosis, 8206 successfully targeted all three analyzed pathogenic autoantigens (ApoB, HSP60, and HMGB1) and inhibited disease progression. These findings suggest that 8206 can potentially serve as a universal treatment vaccine for autoimmune diseases by eliminating the need for exogenous immunogens, with implications for broad applications in immunotherapy.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf068","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:44:38Z","timestamp":1745541878000},"page":"1477-1482","source":"Crossref","is-referenced-by-count":3,"title":["An antigen-less pro-vaccine for treating autoimmunity"],"prefix":"10.1093","volume":"214","author":[{"given":"Guoxing","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, University of Illinois College of Medicine Rockford , Rockford, IL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thura Tun","family":"Oo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Illinois College of Medicine Rockford , 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