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This is believed to result from adaptations at the maternal-fetal interface (MFI), which affect T cell programming, but the identities (i.e. memory subsets and antigenic specificities) of T cells and the signals that mediate T cell fates and functions at the MFI remain poorly understood. We found intact recruitment programs as well as proinflammatory cytokine networks that can act on maternal T cells in an antigen-independent manner. These inflammatory signals elicit T cell expression of costimulatory receptors necessary for tissue retention, which can be engaged by local macrophages. Although proinflammatory molecules elicit T cell effector functions, we show that additional cytokine (transforming growth factor \u03b21) and metabolite (kynurenine) networks may converge to tune T cell function to those of sentinels. Together, these data demonstrate that T cells at the MFI are broadly recruited and restrained in an antigen-independent, cytokine\/metabolite-dependent manner. These mechanisms provide insight into antigen-nonspecific T cell regulation, especially in tissue microenvironments in which they are enriched.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf093","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T22:14:26Z","timestamp":1751148866000},"page":"2221-2237","source":"Crossref","is-referenced-by-count":3,"title":["Cytokine and metabolite networks shape T cell residency and functionality at the term human maternal-fetal interface"],"prefix":"10.1093","volume":"214","author":[{"given":"Nicholas J","family":"Maurice","sequence":"first","affiliation":[{"name":"Molecular and Cellular Biology Graduate Program, University of Washington , Seattle, WA,","place":["United States"]},{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center , Seattle, WA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jami 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