{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T17:01:47Z","timestamp":1776272507752,"version":"3.50.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T00:00:00Z","timestamp":1747440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471852"],"award-info":[{"award-number":["82471852"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271782"],"award-info":[{"award-number":["82271782"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173083"],"award-info":[{"award-number":["82173083"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Provincial Key Laboratory of Immune Regulation and Immunotherapy","award":["2022B1212010009"],"award-info":[{"award-number":["2022B1212010009"]}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515013120"],"award-info":[{"award-number":["2024A1515013120"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2024A0505040013"],"award-info":[{"award-number":["2024A0505040013"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hepatitis B virus (HBV) infection remains a significant global health challenge, characterized by chronic liver inflammation and compromised antiviral immunity. The outcome of HBV infection and associated liver pathogenesis is influenced mainly by the host innate immune and inflammatory responses. Characterizing the mechanisms underlying these responses might provide new therapeutic strategies for HBV treatment. HECT domain and RCC1-like domain 2 (HERC2) belongs to the large HERC family of ubiquitin E3 ligases, which are implicated in tissue development and inflammation. We initially observed that hepatic tissues from chronic hepatitis B patients express lower levels of HERC2 compared with healthy donors. In this study, we identified HERC2 as a critical suppressor of HBV infection. Hepatocyte-specific HERC2-deficient mice exhibited increased susceptibility to HBV infection. Our findings demonstrate that HERC2 directly interacts with TBK1, a vital regulator of the innate immune response, mediating its K33 ubiquitination and activation. This HERC2-mediated activation of TBK1 triggers a signaling cascade that culminates in the activation of transcription factors IRF3 and IRF7, subsequently driving the production of type I interferons, crucial antiviral cytokines. The findings deepen our understanding of the molecular mechanisms underlying HBV pathogenesis and present potential avenues for developing targeted immunomodulatory therapies to combat HBV infection more effectively.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf095","type":"journal-article","created":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T20:01:28Z","timestamp":1747512088000},"page":"1789-1801","source":"Crossref","is-referenced-by-count":1,"title":["Hepatocyte-expressed HERC2 enhances type I interferon\u2013mediated anti-HBV immune response by promoting K33 ubiquitination of TBK1"],"prefix":"10.1093","volume":"214","author":[{"given":"Zhuojun","family":"Zheng","sequence":"first","affiliation":[{"name":"Institute of Medical Research, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University , Guangzhou, Guangdong,","place":["China"]},{"name":"Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Guangdong Province Key Laboratory of Immune Regulation and Immunotherapy, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, Southern Medical University , Guangzhou, Guangdong,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sihang","family":"Cao","sequence":"additional","affiliation":[{"name":"Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Guangdong Province Key Laboratory of Immune Regulation and Immunotherapy, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, Southern Medical University , Guangzhou, Guangdong,","place":["China"]},{"name":"State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong , Pokfulam, Hong Kong SAR,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunzhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Guangdong Province Key Laboratory of Immune Regulation and Immunotherapy, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, Southern Medical University , Guangzhou, Guangdong,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0070-4131","authenticated-orcid":false,"given":"Jialiang","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Guangdong Province Key Laboratory of Immune Regulation and Immunotherapy, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, Southern Medical University , Guangzhou, Guangdong,","place":["China"]},{"name":"Guangdong Province Key Laboratory of Proteomics, Department of Immunology, School of Basic Medical Sciences, Southern Medical University , Guangzhou, Guangdong,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Guangdong Province Key Laboratory of Immune Regulation and Immunotherapy, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, Southern Medical University , Guangzhou, Guangdong,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Lu","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Proteomics, Department of Immunology, School of Basic Medical Sciences, Southern Medical University , Guangzhou, Guangdong,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Zhou","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Proteomics, Department of Immunology, School of Basic Medical Sciences, Southern Medical University , Guangzhou, Guangdong,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7996-1119","authenticated-orcid":false,"given":"Shuofeng","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong , Pokfulam, Hong Kong SAR,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2003-9474","authenticated-orcid":false,"given":"Daming","family":"Zuo","sequence":"additional","affiliation":[{"name":"Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Guangdong Province Key Laboratory of Immune Regulation and Immunotherapy, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, Southern Medical University , Guangzhou, Guangdong,","place":["China"]},{"name":"Guangdong Province Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University , Guangzhou, Guangdong,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9726-8403","authenticated-orcid":false,"given":"Qingyun","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Medical Research, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University , Guangzhou, Guangdong,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,5,17]]},"reference":[{"key":"2025073103523314400_vkaf095-B1","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1080\/22221751.2021.2006580","article-title":"Host-cell interactions in HBV infection and pathogenesis: the emerging role of m6A modification","volume":"10","author":"Kostyusheva","year":"2021","journal-title":"Emerg Microbes Infect"},{"key":"2025073103523314400_vkaf095-B2","doi-asserted-by":"crossref","first-page":"e00046","DOI":"10.1128\/CMR.00046-19","article-title":"Hepatitis B virus: advances in prevention, diagnosis, and therapy","volume":"33","author":"Nguyen","year":"2020","journal-title":"Clin Microbiol Rev"},{"key":"2025073103523314400_vkaf095-B3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41577-021-00549-4","article-title":"Immunobiology and pathogenesis of hepatitis B virus infection","volume":"22","author":"Iannacone","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"2025073103523314400_vkaf095-B4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.ai.2019.11.001","article-title":"Deciphering the pathways to antiviral innate immunity and inflammation","volume":"145","author":"Yang","year":"2020","journal-title":"Adv Immunol"},{"key":"2025073103523314400_vkaf095-B5","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1016\/j.ijbiomac.2022.10.014","article-title":"HIF1alpha lactylation enhances KIAA1199 transcription to promote angiogenesis and vasculogenic mimicry in prostate cancer","volume":"222","author":"Luo","year":"2022","journal-title":"Int J Biol Macromol"},{"key":"2025073103523314400_vkaf095-B6","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00281-021-00864-x","article-title":"Innate immunity in hepatitis B and D virus infection: consequences for viral persistence, inflammation, and T cell recognition","volume":"43","author":"Dandri","year":"2021","journal-title":"Semin Immunopathol"},{"key":"2025073103523314400_vkaf095-B7","doi-asserted-by":"crossref","first-page":"154518","DOI":"10.1016\/j.cyto.2018.08.012","article-title":"Interferon signaling during hepatitis B virus (HBV) infection and HBV-associated hepatocellular carcinoma","volume":"124","author":"Mani","year":"2019","journal-title":"Cytokine"},{"key":"2025073103523314400_vkaf095-B8","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/febs.15035","article-title":"Scavenger receptor A impairs interferon response to HBV infection by limiting TRAF3 ubiquitination through recruiting OTUB1","volume":"287","author":"Xie","year":"2020","journal-title":"FEBS J"},{"key":"2025073103523314400_vkaf095-B9","doi-asserted-by":"crossref","first-page":"7269","DOI":"10.1128\/JVI.79.11.7269-7272.2005","article-title":"Toll-like receptor signaling inhibits hepatitis B virus replication in vivo","volume":"79","author":"Isogawa","year":"2005","journal-title":"J Virol"},{"key":"2025073103523314400_vkaf095-B10","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.4049\/jimmunol.1300512","article-title":"Melanoma differentiation-associated gene 5 senses hepatitis B virus and activates innate immune signaling to suppress virus replication","volume":"191","author":"Lu","year":"2013","journal-title":"J Immunol"},{"key":"2025073103523314400_vkaf095-B11","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41392-021-00687-0","article-title":"Pattern recognition receptors in health and diseases","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"2025073103523314400_vkaf095-B12","doi-asserted-by":"crossref","first-page":"110986","DOI":"10.1016\/j.celrep.2022.110986","article-title":"Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-beta signaling in regulatory T cells","volume":"39","author":"Gu","year":"2022","journal-title":"Cell Rep"},{"key":"2025073103523314400_vkaf095-B13","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3390\/v12030285","article-title":"The interactions between HBV and the innate immunity of hepatocytes","volume":"12","author":"Megahed","year":"2020","journal-title":"Viruses"},{"key":"2025073103523314400_vkaf095-B14","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.3389\/fphys.2019.01014","article-title":"HERCing: structural and functional relevance of the large HERC ubiquitin ligases","volume":"10","author":"Garcia-Cano","year":"2019","journal-title":"Front Physiol"},{"key":"2025073103523314400_vkaf095-B15","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13046-023-02609-0","article-title":"HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway","volume":"42","author":"Liu","year":"2023","journal-title":"J Exp Clin Cancer Res"},{"key":"2025073103523314400_vkaf095-B16","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41420-024-01931-6","article-title":"Autophagy dysregulation via the USP20-ULK1 axis in the HERC2-related neurodevelopmental disorder","volume":"10","author":"Sala-Gaston","year":"2024","journal-title":"Cell Death Discov"},{"key":"2025073103523314400_vkaf095-B17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.clim.2014.06.002","article-title":"The lectin pathway of complement: advantage or disadvantage in HIV pathogenesis?","volume":"154","author":"Ballegaard","year":"2014","journal-title":"Clin Immunol"},{"key":"2025073103523314400_vkaf095-B18","doi-asserted-by":"crossref","first-page":"10735","DOI":"10.1073\/pnas.0600397103","article-title":"HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets","volume":"103","author":"Wong","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025073103523314400_vkaf095-B19","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13046-023-02609-0","article-title":"HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway","volume":"42","author":"Liu","year":"2023","journal-title":"J Exp Clin Cancer Res."},{"key":"2025073103523314400_vkaf095-B20","doi-asserted-by":"crossref","first-page":"39065","DOI":"10.18632\/oncotarget.9687","article-title":"Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1","volume":"7","author":"Bai","year":"2016","journal-title":"Oncotarget"},{"key":"2025073103523314400_vkaf095-B21","doi-asserted-by":"crossref","first-page":"8885","DOI":"10.1128\/JVI.00605-09","article-title":"The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability","volume":"83","author":"Vos","year":"2009","journal-title":"J Virol"},{"key":"2025073103523314400_vkaf095-B22","doi-asserted-by":"crossref","first-page":"e01737","DOI":"10.1128\/JVI.01737-17","article-title":"The human papillomavirus E6 oncoprotein targets USP15 and TRIM25 to suppress RIG-I-mediated innate immune signaling","volume":"92","author":"Chiang","year":"2018","journal-title":"J Virol"},{"key":"2025073103523314400_vkaf095-B23","doi-asserted-by":"crossref","first-page":"10072","DOI":"10.1128\/JVI.00541-07","article-title":"Regulation of hepatitis B virus replication by the phosphatidylinositol 3-kinase-akt signal transduction pathway","volume":"81","author":"Guo","year":"2007","journal-title":"J Virol"},{"key":"2025073103523314400_vkaf095-B24","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1021\/pr501005v","article-title":"Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2","volume":"14","author":"Galligan","year":"2015","journal-title":"J Proteome Res"},{"key":"2025073103523314400_vkaf095-B25","doi-asserted-by":"crossref","first-page":"a021428","DOI":"10.1101\/cshperspect.a021428","article-title":"Immune response in hepatitis B virus infection","volume":"5","author":"Tan","year":"2015","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2025073103523314400_vkaf095-B26","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1743-422X-11-22","article-title":"Innate immune responses in hepatitis B virus (HBV) infection","volume":"11","author":"Busca","year":"2014","journal-title":"Virol J"},{"key":"2025073103523314400_vkaf095-B27","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ygeno.2004.10.006","article-title":"The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects","volume":"85","author":"Hochrainer","year":"2005","journal-title":"Genomics"},{"key":"2025073103523314400_vkaf095-B28","doi-asserted-by":"crossref","first-page":"e00528","DOI":"10.1128\/JVI.00528-18","article-title":"Evolution-guided structural and functional analyses of the HERC family reveal an ancient marine origin and determinants of antiviral activity","volume":"92","author":"Paparisto","year":"2018","journal-title":"J Virol"},{"key":"2025073103523314400_vkaf095-B29","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1053\/jhep.2001.26511","article-title":"Role of hepatitis B, C, and D viruses in dual and triple infection: influence of viral genotypes and hepatitis B precore and basal core promoter mutations on viral replicative interference","volume":"34","author":"Jardi","year":"2001","journal-title":"Hepatology"},{"key":"2025073103523314400_vkaf095-B30","doi-asserted-by":"crossref","first-page":"e29870","DOI":"10.1371\/journal.pone.0029870","article-title":"HERC6 is the main E3 ligase for global ISG15 conjugation in mouse cells","volume":"7","author":"Oudshoorn","year":"2012","journal-title":"PLoS One"},{"key":"2025073103523314400_vkaf095-B31","doi-asserted-by":"crossref","first-page":"117","DOI":"10.16966\/2473-1846.117","article-title":"Review on human immune response against hepatitis B virus (HBV) infection","volume":"2","author":"Molla","year":"2016","journal-title":"J Emerg Dis Virol"},{"key":"2025073103523314400_vkaf095-B32","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1128\/JVI.74.5.2255-2264.2000","article-title":"Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines","volume":"74","author":"McClary","year":"2000","journal-title":"J Virol"},{"key":"2025073103523314400_vkaf095-B33","doi-asserted-by":"crossref","first-page":"436","DOI":"10.3389\/fimmu.2017.00436","article-title":"Hepatitis B virus immunopathology, model systems, and current therapies","volume":"8","author":"Sandhu","year":"2017","journal-title":"Front Immunol"},{"key":"2025073103523314400_vkaf095-B34","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1053\/j.gastro.2013.02.003","article-title":"GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees","volume":"144","author":"Lanford","year":"2013","journal-title":"Gastroenterology"},{"key":"2025073103523314400_vkaf095-B35","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.cyto.2012.05.013","article-title":"Molecular characterization of the type I IFN receptor in two woodchuck species and detection of its expression in liver samples from woodchucks infected with woodchuck hepatitis virus (WHV)","volume":"60","author":"Fan","year":"2012","journal-title":"Cytokine"},{"key":"2025073103523314400_vkaf095-B36","doi-asserted-by":"crossref","first-page":"113870","DOI":"10.1016\/j.celrep.2024.113870","article-title":"HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity","volume":"43","author":"Chu","year":"2024","journal-title":"Cell Rep"},{"key":"2025073103523314400_vkaf095-B37","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ni921","article-title":"IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway","volume":"4","author":"Fitzgerald","year":"2003","journal-title":"Nat Immunol"},{"key":"2025073103523314400_vkaf095-B38","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1073\/pnas.2237236100","article-title":"IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts","volume":"101","author":"McWhirter","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025073103523314400_vkaf095-B39","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature07317","article-title":"STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling","volume":"455","author":"Ishikawa","year":"2008","journal-title":"Nature"},{"key":"2025073103523314400_vkaf095-B40","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1016\/j.drudis.2021.05.016","article-title":"TANK-binding kinase 1 (TBK1): an emerging therapeutic target for drug discovery","volume":"26","author":"Xiang","year":"2021","journal-title":"Drug Discov Today"},{"key":"2025073103523314400_vkaf095-B41","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.3389\/fmicb.2018.01611","article-title":"When hepatitis B virus meets interferons","volume":"9","author":"Tan","year":"2018","journal-title":"Front Microbiol"},{"key":"2025073103523314400_vkaf095-B42","doi-asserted-by":"crossref","first-page":"114294","DOI":"10.1016\/j.celrep.2024.114294","article-title":"TBK1 is ubiquitinated by TRIM5alpha to assemble mitophagy machinery","volume":"43","author":"Saha","year":"2024","journal-title":"Cell Rep"},{"key":"2025073103523314400_vkaf095-B43","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1038\/ni.3588","article-title":"E3 ubiquitin ligase RNF128 promotes innate antiviral immunity through K63-linked ubiquitination of TBK1","volume":"17","author":"Song","year":"2016","journal-title":"Nat Immunol"},{"key":"2025073103523314400_vkaf095-B44","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1038\/s41467-020-16014-0","article-title":"TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination","volume":"11","author":"Deng","year":"2020","journal-title":"Nat Commun"},{"key":"2025073103523314400_vkaf095-B45","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.molcel.2016.08.029","article-title":"USP38 inhibits type I interferon signaling by editing TBK1 ubiquitination through NLRP4 signalosome","volume":"64","author":"Lin","year":"2016","journal-title":"Mol Cell"},{"key":"2025073103523314400_vkaf095-B46","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s13046-022-02352-y","article-title":"The role of TBK1 in cancer pathogenesis and anticancer immunity","volume":"41","author":"Runde","year":"2022","journal-title":"J Exp Clin Cancer Res"},{"key":"2025073103523314400_vkaf095-B47","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nri2337","article-title":"Deubiquitylation and regulation of the immune response","volume":"8","author":"Sun","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"2025073103523314400_vkaf095-B48","doi-asserted-by":"crossref","first-page":"e1005179","DOI":"10.1371\/journal.ppat.1005179","article-title":"DYRK2 negatively regulates type I interferon induction by promoting TBK1 degradation via Ser527 phosphorylation","volume":"11","author":"An","year":"2015","journal-title":"PLoS Pathog"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/214\/7\/1789\/63217321\/vkaf095.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/214\/7\/1789\/63217321\/vkaf095.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T07:52:45Z","timestamp":1753948365000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/214\/7\/1789\/8134294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,17]]},"references-count":48,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,5,17]]},"published-print":{"date-parts":[[2025,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jimmun\/vkaf095","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,5,17]]}}}