{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T19:39:45Z","timestamp":1754163585971,"version":"3.41.2"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T00:00:00Z","timestamp":1747440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R21EY030186"],"award-info":[{"award-number":["1R21EY030186"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Louisville Research Infrastructure Fund","award":["R5535"],"award-info":[{"award-number":["R5535"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We discovered a protective role of G protein-coupled receptor 3 (GPR3) in a mouse model of T cell-mediated autoimmune uveitis. GPR3 is an orphan receptor that maintains Gs-coupling and cyclic AMP production without an exogenous ligand. Consequently, GPR3 deficient (GPR3KO) mice were more susceptible to developing experimental autoimmune uveitis (EAU) induced by immunization with interphotoreceptor retinoid-binding protein (IRBP) or by adoptive transfer of IRBP-specific T cells than their wild type (WT) littermates. T cells isolated from IRBP-immunized GPR3KO mice demonstrated an increase in proliferation and inflammatory cytokine production in response to the specific IRBP antigen and a relatively high resistance to activation-induced T cell death compared to T cells isolated from immunized WT mice. Moreover, a major tight junction protein such as ZO-1 was reduced in GPR3 deficient retina with severe uveitis after IRBP-specific T cells were transferred. Taken together, our findings suggest that constitutively active GPR3 inhibits T cell mediated retinal inflammation.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf099","type":"journal-article","created":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T20:01:29Z","timestamp":1747512089000},"page":"1592-1602","source":"Crossref","is-referenced-by-count":0,"title":["Mice deficient of G-protein coupled receptor 3 (GPR3) developed severe experimental autoimmune uveitis (EAU) through increased effector T cell activities"],"prefix":"10.1093","volume":"214","author":[{"given":"Nu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, School of Medicine , Louisville, KY,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, School of Medicine , Louisville, KY,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deming","family":"Sun","sequence":"additional","affiliation":[{"name":"Doheny Eye Institute & Department Ophthalmology, David Geffen School of Medicine\/UCLA , Los Angeles, CA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry J","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Biochemistry & Molecular Biology, St Louis University School of Medicine , St Louis, MO,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7566-6921","authenticated-orcid":false,"given":"Hui","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, School of Medicine , Louisville, 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