{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:30:54Z","timestamp":1791595854898,"version":"4.3.4"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19 AI128741"],"award-info":[{"award-number":["U19 AI128741"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["P01 AI174856"],"award-info":[{"award-number":["P01 AI174856"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"L.J.P.","award":["R01 AI059457"],"award-info":[{"award-number":["R01 AI059457"]}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1107409"],"award-info":[{"award-number":["OPP1107409"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institutes of Health, Office of the Director","award":["P51 OD011092"],"award-info":[{"award-number":["P51 OD011092"]}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["75N91019D00024"],"award-info":[{"award-number":["75N91019D00024"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Strain 68-1 rhesus CMV (RhCMV) vectors induce immune responses that mediate early, complete replication arrest of SIV infection in \u223c60% of vaccinated rhesus macaques (RMs). This unique efficacy depends on the ability of these vectors to elicit effector memory (EM)-biased CD8+ T cells recognizing SIV peptides presented by MHC-E, rather than MHC-Ia. These efficacious responses still occurred when spread of the 68-1 vector was impaired by deletion of the viral anti-host intrinsic immunity factor phosphoprotein 71 (pp71), but efficacy was lost with a more stringent attenuation strategy based on destabilization of Rh108, the ortholog of the essential human CMV (HCMV) transcription factor UL79 that is required for late viral gene expression. Although unable to produce infectious progeny (ie single-cycle infection), Rh108-deficient vectors elicited durable, high frequency, EM-biased, SIV-specific CD8+ T-cell responses in RMs, but these responses were MHC-Ia\u2013restricted and therefore non-efficacious. Here, we tested a different single-cycle attenuation strategy based on deletion (\u0394) of the glycoprotein L (gL) that is essential for viral entry but allows for late gene expression and viral assembly. \u0394gL 68-1 RhCMV\/SIV vectors, grown on gL-complementing fibroblasts, were robustly immunogenic at doses above 105 PFU, generating high frequency, EM-biased, SIV-specific CD8+ T-cell responses that were also unconventionally restricted, including the MHC-E restriction associated with efficacy. Indeed, these single-cycle vectors manifested replication arrest efficacy in 70% of vaccinated RMs, further linking MHC-E restriction with efficacy, and demonstrating that 68-1 RhCMV\/SIV efficacy does not require vector dissemination within the host.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf104","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:41:58Z","timestamp":1748306518000},"page":"1969-1981","source":"Crossref","is-referenced-by-count":6,"title":["Glycoprotein L\u2013deleted single-cycle rhesus cytomegalovirus vectors elicit MHC-E\u2013restricted CD8+ T cells that protect against SIV"],"prefix":"10.1093","volume":"214","author":[{"given":"Scott G","family":"Hansen","sequence":"first","affiliation":[{"name":"Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University , Beaverton, OR,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6707-7051","authenticated-orcid":false,"given":"John B","family":"Schell","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University , Beaverton, OR,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily E","family":"Marshall","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University , Beaverton, OR,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohita","family":"Ojha","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University , Beaverton, OR,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shana","family":"Feltham","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University , Beaverton, OR,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Morrow","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University , Beaverton, OR,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colette M","family":"Hughes","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University , Beaverton, OR,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxanne M","family":"Gilbride","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University , Beaverton, OR,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia C","family":"Ford","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University , Beaverton, OR,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary C","family":"Cleveland-Rubeor","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University , Beaverton, OR,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R","family":"McArdle","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University , Beaverton, OR,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis","family":"Whitmer","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University , Beaverton, OR,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Barber-Axthelm","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University , Beaverton, OR,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachelle","family":"Bochart","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University , Beaverton, OR,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Smedley","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University , Beaverton, OR,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelli","family":"Oswald","sequence":"additional","affiliation":[{"name":"AIDS and Cancer Virus Program, SAIC Frederick, Inc., Frederick National Laboratory, Leidos Biomedical Research, Inc ., Frederick, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy","family":"Fast","sequence":"additional","affiliation":[{"name":"AIDS and Cancer Virus Program, SAIC Frederick, Inc., Frederick National Laboratory, Leidos Biomedical Research, Inc ., Frederick, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Shoemaker","sequence":"additional","affiliation":[{"name":"AIDS and Cancer Virus Program, SAIC Frederick, Inc., Frederick National Laboratory, Leidos Biomedical Research, Inc ., Frederick, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewelina","family":"Kosmider","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center , Seattle, WA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul T","family":"Edlefsen","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center , Seattle, WA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D","family":"Lifson","sequence":"additional","affiliation":[{"name":"AIDS and Cancer Virus Program, SAIC Frederick, Inc., Frederick National Laboratory, Leidos Biomedical Research, Inc ., Frederick, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Malouli","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University , Beaverton, OR,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Fr\u00fch","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University , Beaverton, OR,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0546-398X","authenticated-orcid":false,"given":"Louis J","family":"Picker","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University , Beaverton, OR,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"2025093000263178100_vkaf104-B1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.virusres.2010.10.031","article-title":"Human cytomegalovirus immunity and immune evasion","volume":"157","author":"Jackson","year":"2011","journal-title":"Virus Res"},{"key":"2025093000263178100_vkaf104-B2","first-page":"469","volume-title":"Cytomegaloviruses: from molecular pathogenesis to intervention.","author":"Jarvis","year":"2013","edition":"2nd ed."},{"key":"2025093000263178100_vkaf104-B3","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1084\/jem.20050882","article-title":"Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects","volume":"202","author":"Sylwester","year":"2005","journal-title":"J Exp Med"},{"key":"2025093000263178100_vkaf104-B4","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1002\/(SICI)1521-4141(199909)29:09<2908::AID-IMMU2908>3.0.CO;2-8","article-title":"Distribution of human CMV-specific memory T cells among the CD8pos. subsets defined by CD57, CD27, and CD45 isoforms","volume":"29","author":"Kern","year":"1999","journal-title":"Eur J Immunol"},{"key":"2025093000263178100_vkaf104-B5","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nri.2016.38","article-title":"T cell responses to cytomegalovirus","volume":"16","author":"Klenerman","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"2025093000263178100_vkaf104-B6","doi-asserted-by":"crossref","first-page":"5811","DOI":"10.4049\/jimmunol.1102695","article-title":"Hidden memories: frontline memory T cells and early pathogen interception","volume":"188","author":"Masopust","year":"2012","journal-title":"J Immunol"},{"key":"2025093000263178100_vkaf104-B7","doi-asserted-by":"crossref","first-page":"e0210252","DOI":"10.1371\/journal.pone.0210252","article-title":"Cytomegalovirus vectors expressing Plasmodium knowlesi antigens induce immune responses that delay parasitemia upon sporozoite challenge","volume":"14","author":"Hansen","year":"2019","journal-title":"PLoS One."},{"key":"2025093000263178100_vkaf104-B8","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/nm.4473","article-title":"Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine","volume":"24","author":"Hansen","year":"2018","journal-title":"Nat Med"},{"key":"2025093000263178100_vkaf104-B9","doi-asserted-by":"crossref","first-page":"6007","DOI":"10.1038\/s41467-024-50345-6","article-title":"Cytomegalovirus vaccine vector-induced effector memory CD4+ T cells protect cynomolgus macaques from lethal aerosolized heterologous avian influenza challenge","volume":"15","author":"Malouli","year":"2024","journal-title":"Nat Commun"},{"key":"2025093000263178100_vkaf104-B10","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.it.2023.02.001","article-title":"Programming cytomegalovirus as an HIV vaccine","volume":"44","author":"Picker","year":"2023","journal-title":"Trends Immunol"},{"key":"2025093000263178100_vkaf104-B11","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature10003","article-title":"Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine","volume":"473","author":"Hansen","year":"2011","journal-title":"Nature"},{"key":"2025093000263178100_vkaf104-B12","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nature12519","article-title":"Immune clearance of highly pathogenic SIV infection","volume":"502","author":"Hansen","year":"2013","journal-title":"Nature"},{"key":"2025093000263178100_vkaf104-B13","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaw2607","article-title":"A live-attenuated RhCMV\/SIV vaccine shows long-term efficacy against heterologous SIV challenge","volume":"11","author":"Hansen","year":"2019","journal-title":"Sci Transl Med."},{"key":"2025093000263178100_vkaf104-B14","doi-asserted-by":"crossref","first-page":"eabg5413","DOI":"10.1126\/sciimmunol.abg5413","article-title":"Cytomegaloviral determinants of CD8+ T cell programming and RhCMV\/SIV vaccine efficacy","volume":"6","author":"Malouli","year":"2021","journal-title":"Sci Immunol"},{"key":"2025093000263178100_vkaf104-B15","doi-asserted-by":"crossref","first-page":"eabn9301","DOI":"10.1126\/sciimmunol.abn9301","article-title":"Myeloid cell tropism enables MHC-E-restricted CD8+ T cell priming and vaccine efficacy by the RhCMV\/SIV vaccine","volume":"7","author":"Hansen","year":"2022","journal-title":"Sci Immunol."},{"key":"2025093000263178100_vkaf104-B16","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1126\/science.aac9475","article-title":"Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E","volume":"351","author":"Hansen","year":"2016","journal-title":"Science"},{"key":"2025093000263178100_vkaf104-B17","doi-asserted-by":"crossref","first-page":"6620","DOI":"10.1128\/JVI.77.12.6620-6636.2003","article-title":"Complete sequence and genomic analysis of rhesus cytomegalovirus","volume":"77","author":"Hansen","year":"2003","journal-title":"J Virol"},{"key":"2025093000263178100_vkaf104-B18","doi-asserted-by":"crossref","first-page":"e1237874","DOI":"10.1126\/science.1237874","article-title":"Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms","volume":"340","author":"Hansen","year":"2013","journal-title":"Science."},{"key":"2025093000263178100_vkaf104-B19","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.chom.2022.07.013","article-title":"Cytomegalovirus-vaccine-induced unconventional T cell priming and control of SIV replication is conserved between primate species","volume":"30","author":"Malouli","year":"2022","journal-title":"Cell Host Microbe"},{"key":"2025093000263178100_vkaf104-B20","doi-asserted-by":"crossref","DOI":"10.1126\/science.abe9233","article-title":"Modulation of MHC-E transport by viral decoy ligands is required for RhCMV\/SIV vaccine efficacy","volume":"372","author":"Verweij","year":"2021","journal-title":"Science."},{"key":"2025093000263178100_vkaf104-B21","doi-asserted-by":"crossref","first-page":"e164692","DOI":"10.1172\/jci.insight.164692","article-title":"Late gene expression-deficient cytomegalovirus vectors elicit conventional T cells that do not protect against SIV","volume":"8","author":"Hansen","year":"2023","journal-title":"JCI Insight."},{"key":"2025093000263178100_vkaf104-B22","first-page":"1","volume-title":"Synopsis of clinical aspects of human cytomgalovirus disease.","author":"Boppana","year":"2013"},{"key":"2025093000263178100_vkaf104-B23","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/path.4437","article-title":"The pathogenesis of human cytomegalovirus","volume":"235","author":"Griffiths","year":"2015","journal-title":"J Pathol"},{"key":"2025093000263178100_vkaf104-B24","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaw2603","article-title":"Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity","volume":"11","author":"Marshall","year":"2019","journal-title":"Sci Transl Med."},{"key":"2025093000263178100_vkaf104-B25","first-page":"49","article-title":"Disabled infectious single cycle-herpes simplex virus (DISC-HSV) as a vector for immunogene therapy of cancer","volume":"4","author":"Rees","year":"2002","journal-title":"Curr Opin Mol Ther"},{"key":"2025093000263178100_vkaf104-B26","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1128\/JVI.01970-10","article-title":"Rhesus and human cytomegalovirus glycoprotein L are required for infection and cell-to-cell spread of virus but cannot complement each other","volume":"85","author":"Bowman","year":"2011","journal-title":"J Virol"},{"key":"2025093000263178100_vkaf104-B27","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.vaccine.2018.08.043","article-title":"Comparison of vaccination with rhesus CMV (RhCMV) soluble gB with a RhCMV replication-defective virus deleted for MHC class I immune evasion genes in a RhCMV challenge model","volume":"37","author":"Valencia","year":"2019","journal-title":"Vaccine"},{"key":"2025093000263178100_vkaf104-B28","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s41579-020-00448-w","article-title":"The structural basis of herpesvirus entry","volume":"19","author":"Connolly","year":"2021","journal-title":"Nat Rev Microbiol"},{"key":"2025093000263178100_vkaf104-B29","doi-asserted-by":"crossref","first-page":"e9681","DOI":"10.1371\/journal.pone.0009681","article-title":"Cross-presentation of a spread-defective MCMV is sufficient to prime the majority of virus-specific CD8+ T cells","volume":"5","author":"Snyder","year":"2010","journal-title":"PLoS One"},{"key":"2025093000263178100_vkaf104-B30","doi-asserted-by":"crossref","first-page":"e1002295","DOI":"10.1371\/journal.ppat.1002295","article-title":"Sustained CD8+ T cell memory inflation after infection with a single-cycle cytomegalovirus","volume":"7","author":"Snyder","year":"2011","journal-title":"PLoS Pathog."},{"key":"2025093000263178100_vkaf104-B31","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.1128\/JVI.77.9.5073-5083.2003","article-title":"Cloning of the full-length rhesus cytomegalovirus genome as an infectious and self-excisable bacterial artificial chromosome for analysis of viral pathogenesis","volume":"77","author":"Chang","year":"2003","journal-title":"J Virol"},{"key":"2025093000263178100_vkaf104-B32","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1016\/S0264-410X(02)00258-X","article-title":"A novel chimeric Rev, Tat, and Nef (Retanef) antigen as a component of an SIV\/HIV vaccine","volume":"20","author":"Hel","year":"2002","journal-title":"Vaccine"},{"key":"2025093000263178100_vkaf104-B33","first-page":"10.32.1","article-title":"Use of bacterial artificial chromosomes in generating targeted mutations in human and mouse cytomegaloviruses","author":"Borst","year":"2007","journal-title":"Curr Protoc Immunol"},{"key":"2025093000263178100_vkaf104-B34","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1172\/JCI67420","article-title":"Cytomegalovirus pp65 limits dissemination but is dispensable for persistence","volume":"124","author":"Malouli","year":"2014","journal-title":"J Clin Invest"},{"key":"2025093000263178100_vkaf104-B35","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nature22984","article-title":"Addendum: immune clearance of highly pathogenic SIV infection","volume":"547","author":"Hansen","year":"2017","journal-title":"Nature"},{"key":"2025093000263178100_vkaf104-B36","doi-asserted-by":"crossref","first-page":"eadp5216","DOI":"10.1126\/sciimmunol.adp5216","article-title":"Human cytomegalovirus UL18 prevents priming of MHC-E- and MHC-II-restricted CD8+ T cells","volume":"9","author":"Malouli","year":"2024","journal-title":"Sci Immunol."},{"key":"2025093000263178100_vkaf104-B37","doi-asserted-by":"crossref","first-page":"e19236","DOI":"10.1038\/s41598-019-55508-w","article-title":"Characterization of a live-attenuated HCMV-based vaccine platform","volume":"9","author":"Caposio","year":"2019","journal-title":"Sci Rep."},{"key":"2025093000263178100_vkaf104-B38","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1126\/science.1185350","article-title":"Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus","volume":"328","author":"Hansen","year":"2010","journal-title":"Science"},{"key":"2025093000263178100_vkaf104-B39","doi-asserted-by":"crossref","first-page":"e1008666","DOI":"10.1371\/journal.ppat.1008666","article-title":"In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome","volume":"16","author":"Taher","year":"2020","journal-title":"PLoS Pathog."},{"key":"2025093000263178100_vkaf104-B40","doi-asserted-by":"crossref","first-page":"eadm8961","DOI":"10.1126\/scitranslmed.adm8961","article-title":"The pentameric complex is not required for congenital CMV transmission in seronegative rhesus macaques","volume":"17","author":"Wang","year":"2025","journal-title":"Sci Transl Med."},{"key":"2025093000263178100_vkaf104-B41","doi-asserted-by":"crossref","first-page":"e1009278","DOI":"10.1371\/journal.ppat.1009278","article-title":"Interleukin-15 response signature predicts RhCMV\/SIV vaccine efficacy","volume":"17","author":"Barren\u00e4s","year":"2021","journal-title":"PLoS Pathog"},{"key":"2025093000263178100_vkaf104-B42","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/S1473-3099(23)00343-2","article-title":"Safety, efficacy, and immunogenicity of a replication-defective human cytomegalovirus vaccine, V160, in cytomegalovirus-seronegative women: a double-blind, randomised, placebo-controlled, phase 2b trial","volume":"23","author":"Das","year":"2023","journal-title":"Lancet Infect Dis"},{"key":"2025093000263178100_vkaf104-B43","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/infdis\/jiz141","article-title":"Phase 1 clinical trial of a conditionally replication-defective human cytomegalovirus (CMV) vaccine in CMV-seronegative subjects","volume":"220","author":"Adler","year":"2019","journal-title":"J Infect Dis"},{"key":"2025093000263178100_vkaf104-B44","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41541-024-00860-w","article-title":"Transcriptional signature of durable effector T cells elicited by a replication defective HCMV vaccine","volume":"9","author":"Ye","year":"2024","journal-title":"NPJ Vaccines"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/214\/8\/1969\/63362846\/vkaf104.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/214\/8\/1969\/63362846\/vkaf104.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:26:43Z","timestamp":1759206403000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/214\/8\/1969\/8150972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,27]]},"references-count":44,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,5,27]]},"published-print":{"date-parts":[[2025,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jimmun\/vkaf104","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,8]]},"published":{"date-parts":[[2025,5,27]]}}}