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Neutrophils are among the cells that have the highest membrane density of surface VISTA. In this study, targeting VISTA on neutrophils with a monoclonal antibody resulted in a striking reduction in their lipopolysaccharide (LPS)- and chemokine-induced peripheral accumulation but did not reduce neutrophil levels at steady state. Fc receptor engagement and macrophages were required for the effects of anti-VISTA antibody on neutrophils. Concomitant with reduced peripheral neutrophil numbers, targeting VISTA increased neutrophil clearance by macrophages in the liver. In a murine model of neutrophil-mediated arthritis, anti-VISTA antibody treatment ameliorated disease severity, which was associated with reduced myeloperoxidase activity in the joints. These studies identify a novel therapeutic opportunity for targeting VISTA to control neutrophil-mediated inflammation and tissue injury.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf132","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T01:36:07Z","timestamp":1750988167000},"page":"2385-2396","source":"Crossref","is-referenced-by-count":3,"title":["The role of VISTA engagement in limiting neutrophil-mediated inflammation"],"prefix":"10.1093","volume":"214","author":[{"given":"Elizabeth C","family":"Nowak","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth , Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiannan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth , Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary T","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth , Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay K","family":"Mendyka","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth , Lebanon, NH,","place":["United States"]},{"name":"Department of Medicine, Dartmouth-Hitchcock Medical Center , Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A","family":"ElTanbouly","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth , Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Wilson L","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth , Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Sergent","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth , Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Louise","family":"Lines","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth , Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole C","family":"Smits","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth , Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodwell","family":"Mabaera","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth , Lebanon, NH,","place":["United States"]},{"name":"Department of Medicine, Dartmouth-Hitchcock Medical Center , Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibani","family":"Rajanna","sequence":"additional","affiliation":[{"name":"ImmuNext Corporation , Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Carriere","sequence":"additional","affiliation":[{"name":"ImmuNext Corporation , Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent","family":"Koehn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Bone Marrow & Blood Transplant & Cellular Therapy, University of Minnesota , Minneapolis, MN,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Allred","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Bone Marrow & Blood Transplant & Cellular Therapy, University of Minnesota , Minneapolis, MN,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9608-9841","authenticated-orcid":false,"given":"Bruce R","family":"Blazar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Bone Marrow & Blood Transplant & Cellular Therapy, University of Minnesota , Minneapolis, MN,","place":["United 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