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One of the major immune evasion strategies involves induction of T helper 2 (Th2)\u2013type response, which in turn downregulates host\u2019s antimycobacterial Th1-type response. Approximately 10% of the Mtb genome is made up of the PE (proline-glutamine))\/PPE (proline-proline-glutamine) family of proteins, whose functions are still not fully understood. PPE18, a member of this family was found to activate interleukin-10\/Th2-type responses by interacting with TLR2 11 to 15 leucine-rich repeat domain. PPE18 was found to inhibit phagosomal acidification and major histocompatibility complex class II\u2013mediated antigen presentation, allowing the bacterium to persist inside macrophages. Mice infected with ppe18 knockout strain of Mtb had lower bacterial burden and better survival rate. In this review, we highlight the functional importance of PPE18 in mycobacterial virulence and explore the potential of PPE18 as a target for therapeutic drug and vaccine development.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf146","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T18:35:58Z","timestamp":1763231758000},"source":"Crossref","is-referenced-by-count":3,"title":["PPE18 protein of\n                    <i>Mycobacterium tuberculosis<\/i>\n                    functions as a virulence factor and is a potential novel therapeutic target"],"prefix":"10.1093","volume":"215","author":[{"given":"Akshay Girish","family":"Manikoth","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Cell Biology, BRIC-Centre for DNA Fingerprinting and Diagnostics, Biotechnology Research and Innovation Council , Uppal, Hyderabad, Telangana,","place":["India"]},{"name":"Graduate Studies, Manipal Academy of Higher Education , Manipal, Karnataka,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0413-8088","authenticated-orcid":false,"given":"Brahmaji","family":"Sontyana","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Cell Biology, BRIC-Centre for DNA Fingerprinting and Diagnostics, Biotechnology Research and Innovation Council , Uppal, Hyderabad, Telangana,","place":["India"]},{"name":"Graduate Studies, Manipal Academy of Higher Education , Manipal, Karnataka,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohini","family":"Shrivastava","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Cell Biology, BRIC-Centre for DNA Fingerprinting and Diagnostics, Biotechnology Research and Innovation Council , Uppal, Hyderabad, Telangana,","place":["India"]},{"name":"Graduate Studies, Manipal Academy of Higher Education , Manipal, Karnataka,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudip","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Molecular Biology Division, ICMR-National Institute of Nutrition, Indian Council of Medical Research , Tarnaka, Hyderabad, Telangana,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5511-3315","authenticated-orcid":false,"given":"Sangita","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Cell Biology, BRIC-Centre for DNA Fingerprinting and Diagnostics, Biotechnology Research and Innovation Council , Uppal, Hyderabad, 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