{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T18:35:37Z","timestamp":1787423737473,"version":"build-2736575974"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Australian Health and Medical Research Council","award":["APP1175411"],"award-info":[{"award-number":["APP1175411"]}]},{"name":"Australian Health and Medical Research Council","award":["APP2028727"],"award-info":[{"award-number":["APP2028727"]}]},{"name":"Australian National Health and Medical Research Council Ideas","award":["APP1182594"],"award-info":[{"award-number":["APP1182594"]}]},{"name":"Australian National Health and Medical Research Council Ideas","award":["APP2028727"],"award-info":[{"award-number":["APP2028727"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Type 2 memory B cells (mBC2), identified in mice as IgG1+CD23+IL-4R\u03b1+CD38+ B cells, which require IL-4 for genesis, are precursors for IgE plasma cells (PC) and considered key in allergy. While IL-21 is critical for normal mBC differentiation, its involvement in mBC2 formation is unknown. Here, we show that although IL-21R-deficient (IL-21R\u2212\/\u2212) mice immunized with ovalbumin generated ovalbumin-specific mBC2, their abundances were lower than in controls one-week post-immunization. This deficit was associated with the accumulation of pre-prememory GC B cells and corresponding deficiencies in pre-memory B cell exit, suggesting a defect in memory differentiation. Germinal centers waned rapidly in IL-21R\u2212\/\u2212 mice and subsequently mBC2 numbers diminished, and IgG1 PC genesis was suppressed. These data show that IL-21 is required for normal mBC2 formation, arguing against the use of IL-21 as a pan-allergy suppressor.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf147","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T01:15:08Z","timestamp":1751591708000},"page":"1898-1905","source":"Crossref","is-referenced-by-count":3,"title":["IL-21 contributes to type 2 memory B cell formation"],"prefix":"10.1093","volume":"214","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8617-2422","authenticated-orcid":false,"given":"Alexandra R","family":"Dvorscek","sequence":"first","affiliation":[{"name":"Department of Immunology, Monash University , Prahran, VIC,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1170-1927","authenticated-orcid":false,"given":"Jesse","family":"Mulder","sequence":"additional","affiliation":[{"name":"Department of Immunology, Monash University , Prahran, VIC,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8765-8814","authenticated-orcid":false,"given":"Zhoujie","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Immunology, Monash University , Prahran, VIC,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4161-1919","authenticated-orcid":false,"given":"Menno C","family":"van Zelm","sequence":"additional","affiliation":[{"name":"Department of Immunology, Monash University , Prahran, VIC,","place":["Australia"]},{"name":"Department of Immunology, University Medical Center, Erasmus MC , Rotterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9928-686X","authenticated-orcid":false,"given":"David M","family":"Tarlinton","sequence":"additional","affiliation":[{"name":"Department of Immunology, Monash 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