{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T18:54:02Z","timestamp":1785351242348,"version":"3.55.0"},"reference-count":116,"publisher":"Oxford University Press (OUP)","issue":"12","funder":[{"name":"Cure Blau Syndrome Foundation"},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["5TL1TR002371-04"],"award-info":[{"award-number":["5TL1TR002371-04"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["5R01EY025250-09"],"award-info":[{"award-number":["5R01EY025250-09"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S Department of Veterans Affairs","doi-asserted-by":"crossref","award":["1I01BX006436-01"],"award-info":[{"award-number":["1I01BX006436-01"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>NOD2 is primarily recognized as a cytosolic bacterial sensor of peptidoglycan, activating a downstream Rip2\/NF-\u03baB\u2013mediated antimicrobial signaling pathway and playing a vital role in host defense against bacterial infections. NOD2 also appears to play a critical role in immune homeostasis, as NOD2 variants have been linked to multiple human inflammatory diseases, including common polymorphisms that increase the risk of Crohn\u2019s disease and rare mutations that cause Blau syndrome. The cellular mechanisms through which mutated NOD2 contributes to disease remain unclear and are currently under investigation. A T cell\u2013intrinsic role for Nod2 in infection and inflammation was suggested almost 15\u2009years ago, leading to intense scrutiny in this research area. This review highlights recent studies establishing a T cell\u2013intrinsic role for NOD2 downstream of T-cell receptor and co-receptor signaling and delineates how NOD2 shapes T-cell responses in both homeostasis and disease, with implications for Blau syndrome and Crohn\u2019s disease.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf204","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T15:54:16Z","timestamp":1755532456000},"page":"3188-3198","source":"Crossref","is-referenced-by-count":3,"title":["Resolving the field: a role for Nod2 in T cells"],"prefix":"10.1093","volume":"214","author":[{"given":"Leah M","family":"Huey","sequence":"first","affiliation":[{"name":"Molecular Microbiology and Immunology, Oregon Health & Science University , Portland, OR,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly L","family":"Rosenzweig","sequence":"additional","affiliation":[{"name":"VA Portland Health Care System , Portland, OR,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2785-8248","authenticated-orcid":false,"given":"Ruth J","family":"Napier","sequence":"additional","affiliation":[{"name":"VA Portland Health Care System , Portland, OR,","place":["United States"]},{"name":"Division of Rheumatology, University of Colorado Anschutz Medical Campus , Aurora, CO,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"key":"2025122315370141000_vkaf204-B1","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/35079114","article-title":"A frameshift mutation in NOD2 associated with susceptibility to Crohn\u2019s disease","volume":"411","author":"Ogura","year":"2001","journal-title":"Nature"},{"key":"2025122315370141000_vkaf204-B2","doi-asserted-by":"publisher","first-page":"8869","DOI":"10.1074\/jbc.C200651200","article-title":"Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection","volume":"278","author":"Girardin","year":"2003","journal-title":"J Biol Chem"},{"key":"2025122315370141000_vkaf204-B3","doi-asserted-by":"publisher","first-page":"5509","DOI":"10.1074\/jbc.C200673200","article-title":"Host recognition of bacterial muramyl dipeptide mediated through NOD2. 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