{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:42:57Z","timestamp":1793400177115,"version":"4.5.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":94,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["G2C20241135"],"award-info":[{"award-number":["G2C20241135"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Science and Technology Program","award":["2024NSFSC1527"],"award-info":[{"award-number":["2024NSFSC1527"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sj\u00f6gren syndrome\u2013related interstitial lung disease (SS-ILD) is a severe complication associated with significant morbidity and mortality. Despite its clinical importance, the underlying pathogenesis remains poorly understood, and effective therapeutic strategies are limited. The development of a reliable animal model for SS-ILD is crucial for elucidating disease mechanisms and facilitating the discovery of novel treatments. In this study, we established a SS-ILD mouse model by administering 3\u2009mg\/kg bleomycin (BLM) via tracheal exposure to NOD\/Ltj mice, a spontaneous model of Sj\u00f6gren syndrome, with ICR mice serving as controls. The successful induction of Sj\u00f6gren syndrome was confirmed through histopathology, and SSA\/SSB ELISAs. Following BLM administration, lung inflammation and fibrosis were evaluated in ICR and NOD\/Ltj mice by imaging, histopathology, and flow cytometry. Both ICR and NOD\/Ltj mice developed lung inflammation and fibrosis after BLM exposure. However, NOD\/Ltj mice exhibited a more pronounced immune response in the lung, characterized by increased infiltration of immune cells, including monocytes, monocyte-derived macrophages, dendritic cells, neutrophils, T cells, and B cells. This model successfully recapitulates key features of SS-ILD, including concurrent lymphocyte infiltration in the salivary glands and inflammation and fibrosis in the lungs. This study established a novel SS-ILD mouse model replicating human disease pathology, offering a valuable tool for investigating pathogenesis and advancing therapeutic development.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf211","type":"journal-article","created":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T15:58:20Z","timestamp":1756051100000},"page":"2861-2870","source":"Crossref","is-referenced-by-count":3,"title":["Establishment of a mouse model of Sj\u00f6gren syndrome\u2013related interstitial lung disease"],"prefix":"10.1093","volume":"214","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0555-0143","authenticated-orcid":false,"given":"Xiuping","family":"Liang","sequence":"first","affiliation":[{"name":"Laboratory of Rheumatology and Immunology, Department of Rheumatology and Immunology, West China Hospital, Sichuan University , Chengdu, Sichuan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Rheumatology and Immunology, Department of Rheumatology and Immunology, West China Hospital, Sichuan University , Chengdu, Sichuan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deying","family":"Huang","sequence":"additional","affiliation":[{"name":"Laboratory of Rheumatology and Immunology, Department of Rheumatology and Immunology, West China Hospital, Sichuan University , Chengdu, Sichuan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueting","family":"Zhao","sequence":"additional","affiliation":[{"name":"Laboratory of Rheumatology and Immunology, Department of Rheumatology and Immunology, West China Hospital, Sichuan University , Chengdu, Sichuan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinlan","family":"Wu","sequence":"additional","affiliation":[{"name":"Laboratory of Rheumatology and Immunology, Department of Rheumatology and Immunology, West China Hospital, Sichuan University , Chengdu, Sichuan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronghui","family":"Liao","sequence":"additional","affiliation":[{"name":"Laboratory of Rheumatology and Immunology, Department of Rheumatology and Immunology, West China Hospital, Sichuan University , Chengdu, Sichuan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wu","sequence":"additional","affiliation":[{"name":"Laboratory of Rheumatology and Immunology, Department of Rheumatology and Immunology, West China Hospital, Sichuan University , Chengdu, Sichuan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Tang","sequence":"additional","affiliation":[{"name":"Laboratory of Rheumatology and Immunology, Department of Rheumatology and Immunology, West China Hospital, Sichuan University , Chengdu, Sichuan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Tan","sequence":"additional","affiliation":[{"name":"Laboratory of Rheumatology and Immunology, Department of Rheumatology and Immunology, West China Hospital, Sichuan University , Chengdu, Sichuan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University , Chengdu,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7669-1579","authenticated-orcid":false,"given":"Yubin","family":"Luo","sequence":"additional","affiliation":[{"name":"Laboratory of Rheumatology and Immunology, Department of Rheumatology and Immunology, West China Hospital, Sichuan University , Chengdu, Sichuan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Rheumatology and Immunology, Department of Rheumatology and Immunology, West China Hospital, Sichuan University , Chengdu, Sichuan,","place":["China"]},{"name":"West China Lecheng Hospital, Sichuan University , Boao, 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