{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:53:03Z","timestamp":1787169183088,"version":"build-2736575974"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32222086"],"award-info":[{"award-number":["32222086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32230110"],"award-info":[{"award-number":["32230110"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovation Team of Aquaculture Environment Safety from Liaoning Province","award":["LT202009"],"award-info":[{"award-number":["LT202009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Increasing evidence indicates that invertebrates have the immune adaptive abilities, which is commonly known as \u201cimmune priming\u201d. However, the mechanism of immune priming is believed to be rather complicated, and it has not been fully elucidated. In the present study, in the oysters where the CgCLec-HTM\/IgR-Syk-BCL10 signaling pathway was interfered by silencing the expression of the main components, the phosphorylation of mTOR and ERK decreased significantly at 6\u2009h after the first Vibrio splendidus stimulation. The messenger RNA (mRNA) transcript levels of the glycolysis-associated genes (CgGluT and CgGK), NAD+\/NADH ratio, lactate concentration, and H3K4me1 and H3K4me3 levels all decreased significantly at 7 d after the first V. splendidus stimulation. Meanwhile, the hemocyte phagocytic rates and the mRNA transcript levels of CgClathrin, CgATPeV, and CgTNF also decreased significantly at 7 d after the first stimulation and 6\u2009h after the second stimulation with V. splendidus. The mRNA transcript levels of CgGluT, CgGK, CgATPeV, and CgTNF; lactate concentration; and H3K4me1 and H3K4me3 levels were all reduced in rapamycin-treated oysters after the first stimulation. The mRNA transcript levels of CgGK, CgClathrin, CgATPeV, and CgTNF; NAD+\/NADH ratio; and the levels of H3K4me1 and H3K4me3 were also reduced in FR180204-treated oysters after the first stimulation. These results indicated that the CLec-HTM\/IgR-Syk-BCL10-mTOR\/ERK signaling pathway regulated histone methylation through mediating the glycolysis to enhance cell phagocytosis and inflammatory response and played a significant regulatory role in the immune priming of Crassostrea gigas, which provided new clues for studying the evolution of immune adaptability.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf218","type":"journal-article","created":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T11:04:41Z","timestamp":1762686281000},"source":"Crossref","is-referenced-by-count":1,"title":["The involvement of CLec-HTM\/IgR-Syk-BCL10-mTOR\/ERK signaling pathway in immune priming of oysters"],"prefix":"10.1093","volume":"215","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1904-7265","authenticated-orcid":false,"given":"Jiejie","family":"Sun","sequence":"first","affiliation":[{"name":"Liaoning Key Laboratory of Marine Animal Immunology and Disease Control, Dalian Ocean University , Dalian,","place":["China"]},{"name":"Liaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Liaoning Key Laboratory of Marine Animal Immunology and Disease Control, Dalian Ocean University , Dalian,","place":["China"]},{"name":"Liaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8150-4249","authenticated-orcid":false,"given":"Tong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Liaoning Key Laboratory of Marine Animal Immunology and Disease Control, Dalian Ocean University , Dalian,","place":["China"]},{"name":"Liaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Wang","sequence":"additional","affiliation":[{"name":"Liaoning Key Laboratory of Marine Animal Immunology and Disease Control, Dalian Ocean University , Dalian,","place":["China"]},{"name":"Liaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Guo","sequence":"additional","affiliation":[{"name":"Liaoning Key Laboratory of Marine Animal Immunology and Disease Control, Dalian Ocean University , Dalian,","place":["China"]},{"name":"Liaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongsheng","family":"Yao","sequence":"additional","affiliation":[{"name":"Liaoning Key Laboratory of Marine Animal Immunology and Disease Control, Dalian Ocean University , Dalian,","place":["China"]},{"name":"Liaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Yan","sequence":"additional","affiliation":[{"name":"Liaoning Key Laboratory of Marine Animal Immunology and Disease Control, Dalian Ocean University , Dalian,","place":["China"]},{"name":"Liaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yang","sequence":"additional","affiliation":[{"name":"Liaoning Key Laboratory of Marine Animal Immunology and Disease Control, Dalian Ocean University , Dalian,","place":["China"]},{"name":"Liaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyi","family":"Mu","sequence":"additional","affiliation":[{"name":"Liaoning Key Laboratory of Marine Animal Immunology and Disease Control, Dalian Ocean University , Dalian,","place":["China"]},{"name":"Liaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1049-9170","authenticated-orcid":false,"given":"Lingling","family":"Wang","sequence":"additional","affiliation":[{"name":"Liaoning Key Laboratory of Marine Animal Immunology and Disease Control, Dalian Ocean University , Dalian,","place":["China"]},{"name":"Liaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University , Dalian,","place":["China"]},{"name":"Qingdao National Laboratory for Marine Science and Technology, Laboratory of Marine Fisheries Science and Food Production Processes , Qingdao,","place":["China"]},{"name":"Dalian Key Laboratory of Aquatic Animal Disease Control, Dalian Ocean University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linsheng","family":"Song","sequence":"additional","affiliation":[{"name":"Liaoning Key Laboratory of Marine Animal Immunology and Disease Control, Dalian Ocean University , Dalian,","place":["China"]},{"name":"Liaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University , Dalian,","place":["China"]},{"name":"Qingdao National Laboratory for Marine Science and Technology, Laboratory of Marine Fisheries Science and Food Production Processes , Qingdao,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"2026012707075389700_vkaf218-B1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.tig.2020.08.017","article-title":"Genetic lesions of type I interferon signalling in human antiviral immunity","volume":"37","author":"Duncan","year":"2021","journal-title":"Trends Genet"},{"key":"2026012707075389700_vkaf218-B2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0952-7915(02)00019-5","article-title":"Innate immunity","volume":"15","author":"Medzhitov","year":"2003","journal-title":"Curr Opin Immunol"},{"key":"2026012707075389700_vkaf218-B3","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nature05762","article-title":"Herpesvirus latency confers symbiotic protection from bacterial infection","volume":"447","author":"Barton","year":"2007","journal-title":"Nature"},{"key":"2026012707075389700_vkaf218-B4","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.chom.2011.04.006","article-title":"Trained immunity: a memory for innate host defense","volume":"9","author":"Netea","year":"2011","journal-title":"Cell Host Microbe"},{"key":"2026012707075389700_vkaf218-B5","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/ni0607-554","article-title":"All roads lead to CARD9","volume":"8","author":"Colonna","year":"2007","journal-title":"Nat Immunol"},{"key":"2026012707075389700_vkaf218-B6","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1038\/ncomms4755","article-title":"An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells","volume":"5","author":"Yasukawa","year":"2014","journal-title":"Nat Commun"},{"key":"2026012707075389700_vkaf218-B7","doi-asserted-by":"crossref","first-page":"151951","DOI":"10.1016\/j.imbio.2020.151951","article-title":"Natural and trained innate immunity against","volume":"225","author":"Ferluga","year":"2020","journal-title":"Immunobiology"},{"key":"2026012707075389700_vkaf218-B8","first-page":"187","article-title":"PAMPs of the fungal cell wall and mammalian PRRs","volume":"425","author":"Hatinguais","year":"2020","journal-title":"Curr Top Microbiol Immunol"},{"key":"2026012707075389700_vkaf218-B9","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.celrep.2018.09.092","article-title":"Targeting SHIP-1 in myeloid cells enhances trained immunity and boosts response to infection","volume":"25","author":"Saz-Leal","year":"2018","journal-title":"Cell Rep"},{"key":"2026012707075389700_vkaf218-B10","doi-asserted-by":"crossref","first-page":"622614","DOI":"10.3389\/fimmu.2020.622614","article-title":"TLR agonists as mediators of trained immunity: mechanistic insight and immunotherapeutic potential to combat infection","volume":"11","author":"Owen","year":"2020","journal-title":"Front Immunol"},{"key":"2026012707075389700_vkaf218-B11","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1177\/1753425910366059","article-title":"Review: Mammalian peptidoglycan recognition proteins (PGRPs) in innate immunity","volume":"16","author":"Dziarski","year":"2010","journal-title":"Innate Immun"},{"key":"2026012707075389700_vkaf218-B12","doi-asserted-by":"crossref","first-page":"100834","DOI":"10.1016\/j.isci.2020.100834","article-title":"An ancient BCR-like signaling promotes ICP production and hemocyte phagocytosis in oyster","volume":"23","author":"Sun","year":"2020","journal-title":"iScience"},{"key":"2026012707075389700_vkaf218-B13","doi-asserted-by":"crossref","first-page":"103498","DOI":"10.1016\/j.dci.2019.103498","article-title":"The involvement of TLR signaling and anti-bacterial effectors in enhanced immune protection of oysters after Vibrio splendidus pre-exposure","volume":"103","author":"Wang","year":"2020","journal-title":"Dev Comp Immunol"},{"key":"2026012707075389700_vkaf218-B14","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.molcel.2013.07.010","article-title":"Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription","volume":"51","author":"Kaikkonen","year":"2013","journal-title":"Mol Cell"},{"key":"2026012707075389700_vkaf218-B15","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cell.2012.12.018","article-title":"Latent enhancers activated by stimulation in differentiated cells","volume":"152","author":"Ostuni","year":"2013","journal-title":"Cell"},{"key":"2026012707075389700_vkaf218-B16","doi-asserted-by":"crossref","first-page":"1251086","DOI":"10.1126\/science.1251086","article-title":"Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity","volume":"345","author":"Saeed","year":"2014","journal-title":"Science"},{"key":"2026012707075389700_vkaf218-B17","doi-asserted-by":"crossref","first-page":"1250684","DOI":"10.1126\/science.1250684","article-title":"mTOR- and HIF-1\u03b1\u2013mediated aerobic glycolysis as metabolic basis for trained immunity","volume":"345","author":"Cheng","year":"2014","journal-title":"Science"},{"key":"2026012707075389700_vkaf218-B18","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/ni.3257","article-title":"The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory","volume":"16","author":"Yoshida","year":"2015","journal-title":"Nat Immunol"},{"key":"2026012707075389700_vkaf218-B19","doi-asserted-by":"crossref","first-page":"104285","DOI":"10.1016\/j.dci.2021.104285","article-title":"Innate immune memory in invertebrates: concept and potential mechanisms","volume":"127","author":"Lanz-Mendoza","year":"2022","journal-title":"Dev Comp Immunol"},{"key":"2026012707075389700_vkaf218-B20","doi-asserted-by":"crossref","first-page":"1397521","DOI":"10.3389\/fimmu.2024.1397521","article-title":"Epigenetic remodeling in insect immune memory","volume":"15","author":"Mukherjee","year":"2024","journal-title":"Front Immunol"},{"key":"2026012707075389700_vkaf218-B21","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3389\/fmicb.2017.00473","article-title":"Methylation on RNA: a potential mechanism related to immune priming within but not across generations","volume":"8","author":"Castro-Vargas","year":"2017","journal-title":"Front Microbiol"},{"key":"2026012707075389700_vkaf218-B22","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1248\/yakushi.126.1207","article-title":"Humoral and cellular responses in innate immunity","volume":"126","author":"Nakanishi","year":"2006","journal-title":"Yakugaku Zasshi"},{"key":"2026012707075389700_vkaf218-B23","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1172\/JCI128075","article-title":"Post-sepsis immunosuppression depends on NKT cell regulation of mTOR\/IFN-\u03b3 in NK cells","volume":"130","author":"Kim","year":"2020","journal-title":"J Clin Invest"},{"key":"2026012707075389700_vkaf218-B24","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/nature05836","article-title":"Gene-specific control of inflammation by TLR-induced chromatin modifications","volume":"447","author":"Foster","year":"2007","journal-title":"Nature"},{"key":"2026012707075389700_vkaf218-B25","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.chom.2012.06.006","article-title":"Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes","volume":"12","author":"Quintin","year":"2012","journal-title":"Cell Host Microbe"},{"key":"2026012707075389700_vkaf218-B26","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.0105-2896.2004.0117.x","article-title":"Invertebrate immune systems\u2014not homogeneous, not simple, not well understood","volume":"198","author":"Loker","year":"2004","journal-title":"Immunol Rev"},{"key":"2026012707075389700_vkaf218-B27","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jip.2015.05.010","article-title":"Genetic improvement for disease resistance in oysters: a review","volume":"131","author":"D\u00e9gremont","year":"2015","journal-title":"J Invertebr Pathol"},{"key":"2026012707075389700_vkaf218-B28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.dci.2017.05.025","article-title":"The oyster immunity","volume":"80","author":"Wang","year":"2018","journal-title":"Dev Comp Immunol"},{"key":"2026012707075389700_vkaf218-B29","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.4049\/jimmunol.1900238","article-title":"CgCLec-HTM-mediated signaling pathway regulates lipopolysaccharide-induced CgIL-17 and CgTNF production in oyster","volume":"203","author":"Sun","year":"2019","journal-title":"J Immunol"},{"key":"2026012707075389700_vkaf218-B30","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.fsi.2021.12.009","article-title":"BCL10 regulates the production of proinflammatory cytokines by activating MAPK-NF-kB\/Rel signaling pathway in oysters","volume":"120","author":"Zhang","year":"2022","journal-title":"Fish Shellfish Immunol"},{"key":"2026012707075389700_vkaf218-B31","doi-asserted-by":"crossref","first-page":"100085","DOI":"10.1016\/j.fsirep.2023.100085","article-title":"Syk regulates the haemocyte autophagy through inducing the mRNA expressions of autophagy-related genes and the cleavage of CgLC3 in oyster antibacterial immunity","volume":"4","author":"Yao","year":"2023","journal-title":"Fish Shellfish Immunol Rep"},{"key":"2026012707075389700_vkaf218-B32","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"2026012707075389700_vkaf218-B33","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.fsi.2017.12.003","article-title":"Autophagic processes in Mytilus galloprovincialis hemocytes: effects of Vibrio tapetis","volume":"73","author":"Balbi","year":"2018","journal-title":"Fish Shellfish Immunol"},{"key":"2026012707075389700_vkaf218-B34","doi-asserted-by":"crossref","first-page":"640","DOI":"10.4049\/jimmunol.2100007","article-title":"CLec-TM1\u2013ERK\u2013GSK3\u03b2 pathway regulates Vibrio splendidus induced IL-17 production in oyster","volume":"207","author":"Sun","year":"2021","journal-title":"J Immunol"},{"key":"2026012707075389700_vkaf218-B35","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.dci.2019.04.004","article-title":"Hemolymph C1qDC promotes the phagocytosis of oyster Crassostrea gigas hemocytes by interacting with the membrane receptor beta-integrin","volume":"98","author":"Lv","year":"2019","journal-title":"Dev Comp Immunol"},{"key":"2026012707075389700_vkaf218-B36","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.coi.2019.12.001","article-title":"Innate immunological memory: from plants to animals","volume":"62","author":"Sharrock","year":"2020","journal-title":"Curr Opin Immunol"},{"key":"2026012707075389700_vkaf218-B37","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.it.2005.02.001","article-title":"Specific memory within innate immune systems","volume":"26","author":"Kurtz","year":"2005","journal-title":"Trends Immunol"},{"key":"2026012707075389700_vkaf218-B38","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41590-020-00845-6","article-title":"Trained immunity, tolerance, priming and differentiation: distinct immunological processes","volume":"22","author":"Divangahi","year":"2021","journal-title":"Nat Immunol"},{"key":"2026012707075389700_vkaf218-B39","doi-asserted-by":"crossref","first-page":"e0004921","DOI":"10.1128\/CMR.00049-21","article-title":"Trained immunity as a preventive measure for surgical site infections","volume":"34","author":"Steeg","year":"2021","journal-title":"Clin Microbiol Rev"},{"key":"2026012707075389700_vkaf218-B40","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/een.12300","article-title":"Insect immune priming: ecology and experimental evidences","volume":"41","author":"Contreras-Gardu\u00f1o","year":"2016","journal-title":"Ecol Entomol"},{"key":"2026012707075389700_vkaf218-B41","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nature11413","article-title":"The oyster genome reveals stress adaptation and complexity of shell formation","volume":"490","author":"Zhang","year":"2012","journal-title":"Nature"},{"key":"2026012707075389700_vkaf218-B42","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1042\/CS20180548","article-title":"Adaptive innate immunity or innate adaptive immunity?","volume":"133","author":"\u010cern\u00fd","year":"2019","journal-title":"Clin Sci (Lond)"},{"key":"2026012707075389700_vkaf218-B43","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.immuni.2020.10.011","article-title":"The intersection of epigenetics and metabolism in trained immunity","volume":"54","author":"Fanucchi","year":"2021","journal-title":"Immunity"},{"key":"2026012707075389700_vkaf218-B44","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.molimm.2015.09.013","article-title":"Sonic hedgehog-responsive lipoxygenases and cyclooxygenase-2 modulate Dectin-1-induced inflammatory cytokines","volume":"68","author":"Karnam","year":"2015","journal-title":"Mol Immunol"},{"key":"2026012707075389700_vkaf218-B45","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.smim.2016.09.002","article-title":"Immunometabolic circuits in trained immunity","volume":"28","author":"Arts","year":"2016","journal-title":"Semin Immunol"},{"key":"2026012707075389700_vkaf218-B46","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.cmet.2016.10.008","article-title":"Glutaminolysis and fumarate accumulation integrate immunometabolic and epigenetic programs in trained immunity","volume":"24","author":"Arts","year":"2016","journal-title":"Cell Metab"},{"key":"2026012707075389700_vkaf218-B47","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.1074\/jbc.RA119.012231","article-title":"The evolutionarily conserved MAPK\/Erk signaling promotes ancestral T-cell immunity in fish via c-Myc\u2013mediated glycolysis","volume":"295","author":"Wei","year":"2020","journal-title":"J Biol Chem"},{"key":"2026012707075389700_vkaf218-B48","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.4049\/jimmunol.2000294","article-title":"IgIT-mediated signaling inhibits the antimicrobial immune response in oyster hemocytes","volume":"205","author":"Sun","year":"2020","journal-title":"J Immunol"},{"key":"2026012707075389700_vkaf218-B49","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.4049\/jimmunol.2300599","article-title":"Fish uses CTLA-4 immune checkpoint to suppress mTORC1-controlled T-cell glycolysis and immunity","volume":"212","author":"Zhang","year":"2024","journal-title":"J Immunol"},{"key":"2026012707075389700_vkaf218-B50","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cell.2007.05.009","article-title":"High-resolution profiling of histone methylations in the human genome","volume":"129","author":"Barski","year":"2007","journal-title":"Cell"},{"key":"2026012707075389700_vkaf218-B51","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature07829","article-title":"Histone modifications at human enhancers reflect global cell-type-specific gene expression","volume":"459","author":"Heintzman","year":"2009","journal-title":"Nature"},{"key":"2026012707075389700_vkaf218-B52","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1126\/science.1243490","article-title":"Exonic transcription factor binding directs codon choice and affects protein evolution","volume":"342","author":"Stergachis","year":"2013","journal-title":"Science"},{"key":"2026012707075389700_vkaf218-B53","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.cell.2013.09.053","article-title":"Super-enhancers in the control of cell identity and disease","volume":"155","author":"Hnisz","year":"2013","journal-title":"Cell"},{"key":"2026012707075389700_vkaf218-B54","doi-asserted-by":"crossref","first-page":"e106188","DOI":"10.15252\/embj.2020106188","article-title":"TPL-2 kinase induces phagosome acidification to promote macrophage killing of bacteria","volume":"40","author":"Breyer","year":"2021","journal-title":"EMBO J"},{"key":"2026012707075389700_vkaf218-B55","doi-asserted-by":"crossref","first-page":"16043","DOI":"10.1074\/jbc.M113.473223","article-title":"Dectin-1 activation controls maturation of \u03b2-1,3-glucan-containing phagosomes","volume":"288","author":"Mansour","year":"2013","journal-title":"J Biol Chem"},{"key":"2026012707075389700_vkaf218-B56","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/raq.12863","article-title":"Progress and perspective of trained immunity in teleost fish","volume":"16","author":"You","year":"2024","journal-title":"Rev Aquacult"},{"key":"2026012707075389700_vkaf218-B57","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1371\/journal.ppat.0030026","article-title":"A specific primed immune response in Drosophila is dependent on phagocytes","volume":"3","author":"Pham","year":"2007","journal-title":"Plos Pathog"},{"key":"2026012707075389700_vkaf218-B58","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jip.2011.02.006","article-title":"Enhanced immune defences in Pacific white shrimp (Litopenaeus vannamei) post-exposure to a vibrio vaccine","volume":"107","author":"Powell","year":"2011","journal-title":"J Invertebr Pathol"},{"key":"2026012707075389700_vkaf218-B59","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.3389\/fimmu.2019.02041","article-title":"The enhanced immune protection in Chinese mitten crab Eriocheir sinensis against the second exposure to bacteria aeromonas hydrophila","volume":"10","author":"Wang","year":"2019","journal-title":"Front Immunol"},{"key":"2026012707075389700_vkaf218-B60","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.dci.2014.02.015","article-title":"The specifically enhanced cellular immune responses in Pacific oyster (Crassostrea gigas) against secondary challenge with","volume":"45","author":"Zhang","year":"2014","journal-title":"Dev Comp Immunol"},{"key":"2026012707075389700_vkaf218-B61","first-page":"1","article-title":"The regulation of inflammation by innate and adaptive lymphocytes","volume":"2018","author":"Alex","year":"2018","journal-title":"J Immunol Res"},{"key":"2026012707075389700_vkaf218-B62","doi-asserted-by":"crossref","first-page":"100897","DOI":"10.1016\/j.mam.2020.100897","article-title":"Immunometabolic control of trained immunity","volume":"77","author":"Riksen","year":"2021","journal-title":"Mol Aspects Med"},{"key":"2026012707075389700_vkaf218-B63","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.fsi.2014.12.038","article-title":"A novel vertebrates Toll-like receptor counterpart regulating the anti-microbial peptides expression in the freshwater crayfish, Procambarus clarkii","volume":"43","author":"Wang","year":"2015","journal-title":"Fish Shellfish Immunol"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/215\/1\/vkaf218\/65246251\/vkaf218.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/215\/1\/vkaf218\/65246251\/vkaf218.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:08:10Z","timestamp":1769515690000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/doi\/10.1093\/jimmun\/vkaf218\/8317158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,6]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,11,6]]},"published-print":{"date-parts":[[2026,1,21]]}},"URL":"https:\/\/doi.org\/10.1093\/jimmun\/vkaf218","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2025,11,6]]},"article-number":"vkaf218"}}