{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:02:29Z","timestamp":1793152949833,"version":"4.5.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271755"],"award-info":[{"award-number":["82271755"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Peking University People\u2019s Hospital Scientific Research Development Funds","award":["RDGS2024-04"],"award-info":[{"award-number":["RDGS2024-04"]}]},{"name":"National Center for Protein Sciences at Peking University in Beijing","award":["KF-202305"],"award-info":[{"award-number":["KF-202305"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mucosal-associated invariant T (MAIT) cells play a vital role in immune responses, yet their involvement in autoimmune diseases such as Sj\u00f6gren\u2019s disease (SjD) remains unclear. CD55, a key regulator of complement activation, influences immune cell function. This study investigates CD55 expression on MAIT cells in SjD patients and healthy controls, evaluating its potential as a diagnostic marker. Flow cytometry was used to assess CD55 expression on MAIT cell subsets, including CD4\u2212CD8+, CD4+CD8\u2212, double-positive (DP), and double-negative (DN), in peripheral blood from SjD patients and healthy controls. Functional markers (PD-1, CD83, and CD44), cytokine production (TNF-\u03b1, IFN-\u03b3, IL-17, IL-22), and granzyme B (GZMB) secretion were analyzed following 5-OP-RU and brefeldin A stimulation. Receiver operating characteristic (ROC) analysis was conducted to evaluate the diagnostic utility of CD55 expression. CD55 was highly expressed on MAIT cells, with the highest expression intensity observed in DP MAIT cells, followed by CD4+CD8\u2212 MAIT and CD4\u2212CD8+ MAIT, with the lowest expression found in DN MAIT cells. CD55hi MAIT cells demonstrated significantly higher percentages of PD-1+, CD83+, and CD44+ cells, along with enhanced cytokine and GZMB secretion following stimulation. In SjD patients, CD55 expression was significantly upregulated in MAIT cells. ROC analysis indicated that CD55hi MAIT cells have potential diagnostic value for SjD. CD55 is highly expressed on MAIT cells, with upregulation in SjD patients correlating with inflammation and autoantibodies, suggesting CD55hi MAIT cells as a potential diagnostic marker for SjD.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf226","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T18:37:22Z","timestamp":1756924642000},"page":"3283-3293","source":"Crossref","is-referenced-by-count":2,"title":["CD55hi MAIT cells with elevated cytokine secretion and activation markers serve as potential diagnostic indicators in Sj\u00f6gren\u2019s disease"],"prefix":"10.1093","volume":"214","author":[{"given":"Yiming","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Peking University People\u2019s Hospital , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanxi","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Peking University Health Science Center , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2578-8359","authenticated-orcid":false,"given":"Bohao","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Peking University Health Science Center , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuzheng","family":"Song","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Peking University Health Science Center , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking University People\u2019s Hospital , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayibaota","family":"Bahabayi","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking University People\u2019s Hospital , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking University People\u2019s Hospital , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking University People\u2019s Hospital , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"key":"2025122315374590500_vkaf226-B1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41584-024-01135-3","article-title":"Update on the pathophysiology and treatment of primary Sj\u00f6gren syndrome","volume":"20","author":"Baldini","year":"2024","journal-title":"Nat Rev Rheumatol"},{"key":"2025122315374590500_vkaf226-B2","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1056\/NEJMcp1702514","article-title":"Primary Sjogren\u2019s syndrome","volume":"378","author":"Mariette","year":"2018","journal-title":"N Engl J Med"},{"key":"2025122315374590500_vkaf226-B3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10238-021-00728-6","article-title":"Sj\u00f6gren\u2019s syndrome: a systemic autoimmune disease","volume":"22","author":"Negrini","year":"2022","journal-title":"Clin Exp Med"},{"key":"2025122315374590500_vkaf226-B4","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1136\/annrheumdis-2016-209952","article-title":"Influence of geolocation and ethnicity on the phenotypic expression of primary Sj\u00f6gren\u2019s syndrome at diagnosis in 8310 patients: a cross-sectional study from the Big Data Sj\u00f6gren Project Consortium","volume":"76","author":"Brito-Zer\u00f3n","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"2025122315374590500_vkaf226-B5","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41584-023-01057-6","article-title":"Epidemiology of Sj\u00f6gren syndrome","volume":"20","author":"Beydon","year":"2024","journal-title":"Nat Rev Rheumatol"},{"key":"2025122315374590500_vkaf226-B6","first-page":"450","article-title":"Rate, risk factors and causes of mortality in patients with Sj\u00f6gren\u2019s syndrome: a systematic review and meta-analysis of cohort studies","volume":"55","author":"Singh","year":"2016","journal-title":"Rheumatology (Oxford)"},{"key":"2025122315374590500_vkaf226-B7","doi-asserted-by":"crossref","first-page":"E5434","DOI":"10.1073\/pnas.1705759114","article-title":"Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines","volume":"114","author":"Dias","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025122315374590500_vkaf226-B8","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/s41590-019-0444-8","article-title":"The biology and functional importance of MAIT cells","volume":"20","author":"Godfrey","year":"2019","journal-title":"Nat Immunol"},{"key":"2025122315374590500_vkaf226-B9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1084\/jem.178.1.1","article-title":"Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha\/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain","volume":"178","author":"Porcelli","year":"1993","journal-title":"J Exp Med"},{"key":"2025122315374590500_vkaf226-B10","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/ni.1890","article-title":"Antimicrobial activity of mucosal-associated invariant T cells","volume":"11","author":"Le Bourhis","year":"2010","journal-title":"Nat Immunol"},{"key":"2025122315374590500_vkaf226-B11","doi-asserted-by":"crossref","first-page":"e1000407","DOI":"10.1371\/journal.pbio.1000407","article-title":"Human mucosal associated invariant T cells detect bacterially infected cells","volume":"8","author":"Gold","year":"2010","journal-title":"PLoS Biol"},{"key":"2025122315374590500_vkaf226-B12","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/imcb.12021","article-title":"Human blood MAIT cell subsets defined using MR1 tetramers","volume":"96","author":"Gherardin","year":"2018","journal-title":"Immunol Cell Biol"},{"key":"2025122315374590500_vkaf226-B13","doi-asserted-by":"crossref","first-page":"3486","DOI":"10.3390\/ijms25063486","article-title":"Investigating V\u03b17.2(+)\/CD161(-) T cell and MAIT cell profiles using flow cytometry in healthy subjects and subjects with atopic dermatitis","volume":"25","author":"Singh","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2025122315374590500_vkaf226-B14","doi-asserted-by":"crossref","first-page":"5895","DOI":"10.3390\/ijms25115895","article-title":"A comprehensive investigation of stimulatory agents on MAIT and V\u03b17.2+\/CD161\u2212 T cell response and effects of immunomodulatory drugs","volume":"25","author":"Singh","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2025122315374590500_vkaf226-B15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-1-0716-0207-2_7","article-title":"Human MAIT cell activation in vitro","volume":"2098","author":"Hagel","year":"2020","journal-title":"Methods Mol Biol"},{"key":"2025122315374590500_vkaf226-B16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/eji.201343509","article-title":"CD161++ CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner","volume":"44","author":"Ussher","year":"2014","journal-title":"Eur J Immunol"},{"key":"2025122315374590500_vkaf226-B17","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.4049\/jimmunol.1302701","article-title":"Mucosal-associated invariant T cell deficiency in systemic lupus erythematosus","volume":"193","author":"Cho","year":"2014","journal-title":"J Immunol"},{"key":"2025122315374590500_vkaf226-B18","doi-asserted-by":"crossref","first-page":"974","DOI":"10.4049\/jimmunol.1701213","article-title":"Production of IL-17 by MAIT cells is increased in multiple sclerosis and is associated with IL-7 receptor expression","volume":"200","author":"Willing","year":"2018","journal-title":"J Immunol"},{"key":"2025122315374590500_vkaf226-B19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13075-018-1799-1","article-title":"Altered composition and phenotype of mucosal-associated invariant T cells in early untreated rheumatoid arthritis","volume":"21","author":"Koppejan","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"2025122315374590500_vkaf226-B20","doi-asserted-by":"crossref","first-page":"114250","DOI":"10.1016\/j.biopha.2023.114250","article-title":"New insights into MAIT cells in autoimmune diseases","volume":"159","author":"Fan","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"2025122315374590500_vkaf226-B21","doi-asserted-by":"crossref","first-page":"1017157","DOI":"10.3389\/fimmu.2022.1017157","article-title":"In patients with primary Sj\u00f6gren\u2019s syndrome innate-like MAIT cells display upregulated IL-7r, IFN-\u03b3, and IL-21 expression and have increased proportions of CCR9 and CXCR5-expressing cells","volume":"13","author":"Hinrichs","year":"2022","journal-title":"Front Immunol"},{"key":"2025122315374590500_vkaf226-B22","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1002\/eji.201646300","article-title":"Mucosal-associated invariant T cells are reduced and functionally immature in the peripheral blood of primary Sj\u00f6gren\u2019s syndrome patients","volume":"46","author":"Wang","year":"2016","journal-title":"Eur J Immunol"},{"key":"2025122315374590500_vkaf226-B23","doi-asserted-by":"crossref","first-page":"17256","DOI":"10.1038\/s41598-024-67901-1","article-title":"Role of mucosal-associated invariant T cells dynamics in pathogenesis of Sj\u00f6gren syndrome","volume":"14","author":"Chauffier","year":"2024","journal-title":"Sci Rep"},{"key":"2025122315374590500_vkaf226-B24","first-page":"485","article-title":"Structure and function of decay accelerating factor CD55","volume":"123","author":"Nicholson-Weller","year":"1994","journal-title":"J Lab Clin Med"},{"key":"2025122315374590500_vkaf226-B25","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.4110\/in.2018.18.e11","article-title":"Beyond the role of CD55 as a complement component","volume":"18","author":"Dho","year":"2018","journal-title":"Immune Netw"},{"key":"2025122315374590500_vkaf226-B26","doi-asserted-by":"crossref","first-page":"22023","DOI":"10.1074\/jbc.M702588200","article-title":"Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55","volume":"282","author":"Abbott","year":"2007","journal-title":"J Biol Chem"},{"key":"2025122315374590500_vkaf226-B27","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.4049\/jimmunol.149.6.2055","article-title":"Decay-accelerating factor expression on either effector or target cells inhibits cytotoxicity by human natural killer cells","volume":"149","author":"Finberg","year":"1992","journal-title":"J Immunol"},{"key":"2025122315374590500_vkaf226-B28","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1084\/jem.20040863","article-title":"The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo","volume":"201","author":"Liu","year":"2005","journal-title":"J Exp Med"},{"key":"2025122315374590500_vkaf226-B29","doi-asserted-by":"crossref","first-page":"113822","DOI":"10.1016\/j.intimp.2024.113822","article-title":"CD55 characterizes regulatory T cells with reduced functionality and is downregulated in rheumatoid arthritis","volume":"145","author":"Bahabayi","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"2025122315374590500_vkaf226-B30","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/rheumatology\/keh407","article-title":"Hypocomplementaemia as an immunological marker of morbidity and mortality in patients with primary Sjogren\u2019s syndrome","volume":"44","author":"Ramos-Casals","year":"2005","journal-title":"Rheumatology (Oxford)"},{"key":"2025122315374590500_vkaf226-B31","doi-asserted-by":"crossref","first-page":"e22585","DOI":"10.1002\/jcla.22585","article-title":"Immunophenotypes and clinical features of lymphocytes in the labial gland of primary Sjogren\u2019s syndrome patients","volume":"32","author":"Sun","year":"2018","journal-title":"J Clin Lab Anal"},{"key":"2025122315374590500_vkaf226-B32","doi-asserted-by":"crossref","first-page":"357","DOI":"10.5114\/reum.2020.102000","article-title":"The complement system in primary Sj\u00f6gren\u2019s syndrome: the expression of certain cascade and regulatory proteins in labial salivary glands\u2014observational study","volume":"58","author":"Legatowicz-Koprowska","year":"2020","journal-title":"Reumatologia"},{"key":"2025122315374590500_vkaf226-B33","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/ard.61.6.554","article-title":"Classification criteria for Sj\u00f6gren\u2019s syndrome: a revised version of the European criteria proposed by the American-European consensus group","volume":"61","author":"Vitali","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"2025122315374590500_vkaf226-B34","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s12943-024-02023-w","article-title":"Regulatory mechanisms of PD-1\/PD-L1 in cancers","volume":"23","author":"Lin","year":"2024","journal-title":"Mol Cancer"},{"key":"2025122315374590500_vkaf226-B35","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1002\/eji.200324228","article-title":"Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses","volume":"33","author":"Liang","year":"2003","journal-title":"Eur J Immunol"},{"key":"2025122315374590500_vkaf226-B36","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3389\/fimmu.2020.00721","article-title":"The CD83 molecule\u2014an important immune checkpoint","volume":"11","author":"Grosche","year":"2020","journal-title":"Front Immunol"},{"key":"2025122315374590500_vkaf226-B37","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1046\/j.1365-3083.2003.01303.x","article-title":"Enhanced activation of CD83-positive T cells","volume":"58","author":"Wolenski","year":"2003","journal-title":"Scand J Immunol"},{"key":"2025122315374590500_vkaf226-B38","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.3390\/ijms24032831","article-title":"CD83 regulates the immune responses in inflammatory disorders","volume":"24","author":"Riaz","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2025122315374590500_vkaf226-B39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fimmu.2012.00023","article-title":"Regulation of antigen-experienced T cells: lessons from the quintessential memory marker CD44","volume":"3","author":"Baaten","year":"2012","journal-title":"Front Immunol"},{"key":"2025122315374590500_vkaf226-B40","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.4049\/jimmunol.159.6.2549","article-title":"CD44 activation and associated primary adhesion is inducible via T cell receptor stimulation","volume":"159","author":"DeGrendele","year":"1997","journal-title":"J Immunol"},{"key":"2025122315374590500_vkaf226-B41","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.autrev.2006.09.008","article-title":"The role of complement regulatory proteins (CD55 and CD59) in the pathogenesis of autoimmune hemocytopenias","volume":"6","author":"Ruiz-Arg\u00fcelles","year":"2007","journal-title":"Autoimmun Rev"},{"key":"2025122315374590500_vkaf226-B42","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1002\/art.27347","article-title":"Deletion of either CD55 or CD97 ameliorates arthritis in mouse models","volume":"62","author":"Hoek","year":"2010","journal-title":"Arthritis Rheum"},{"key":"2025122315374590500_vkaf226-B43","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.3389\/fimmu.2019.01746","article-title":"Role of regulatory immune cells and molecules in autoimmune bullous dermatoses","volume":"10","author":"Cao","year":"2019","journal-title":"Front Immunol"},{"key":"2025122315374590500_vkaf226-B44","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1002\/eji.201747140","article-title":"IL-17 polarization of MAIT cells is derived from the activation of two different pathways","volume":"47","author":"Guggino","year":"2017","journal-title":"Eur J Immunol"},{"key":"2025122315374590500_vkaf226-B45","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/rheumatology\/33.8.707","article-title":"Expression of complement regulatory molecules and other surface markers on neutrophils from synovial fluid and blood of patients with rheumatoid arthritis","volume":"33","author":"Jones","year":"1994","journal-title":"Br J Rheumatol"},{"key":"2025122315374590500_vkaf226-B46","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3389\/fimmu.2018.00472","article-title":"Hyper-expression of PD-1 is associated with the levels of exhausted and dysfunctional phenotypes of circulating CD161(++)TCR iV\u03b17.2(+) mucosal-associated invariant T cells in chronic hepatitis B virus infection","volume":"9","author":"Yong","year":"2018","journal-title":"Front Immunol"},{"key":"2025122315374590500_vkaf226-B47","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.4049\/jimmunol.1700615","article-title":"Activation of human mucosal-associated invariant T cells induces CD40L-dependent maturation of monocyte-derived and primary dendritic cells","volume":"199","author":"Salio","year":"2017","journal-title":"J Immunol"},{"key":"2025122315374590500_vkaf226-B48","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/imcb.1034","article-title":"MAIT cells: an historical and evolutionary perspective","volume":"96","author":"Lantz","year":"2018","journal-title":"Immunol Cell Biol"},{"key":"2025122315374590500_vkaf226-B49","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.3389\/fimmu.2020.01556","article-title":"The immune modulating properties of mucosal-associated invariant T cells","volume":"11","author":"Ioannidis","year":"2020","journal-title":"Front Immunol"},{"key":"2025122315374590500_vkaf226-B50","doi-asserted-by":"crossref","first-page":"106878","DOI":"10.1016\/j.intimp.2020.106878","article-title":"Relationships between increased circulating YKL-40, IL-6 and TNF-\u03b1 levels and phenotypes and disease activity of primary Sj\u00f6gren\u2019s syndrome","volume":"88","author":"Chen","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"2025122315374590500_vkaf226-B51","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1136\/ard.2011.154013","article-title":"Potential involvement of IL-22 and IL-22\u2013producing cells in the inflamed salivary glands of patients with Sjogren\u2019s syndrome","volume":"71","author":"Ciccia","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"2025122315374590500_vkaf226-B52","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.4049\/jimmunol.2100522","article-title":"Single-cell transcriptional profiling reveals signatures of helper, effector, and regulatory MAIT cells during homeostasis and activation","volume":"208","author":"Vorkas","year":"2022","journal-title":"J Immunol"},{"key":"2025122315374590500_vkaf226-B53","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1097\/JTO.0b013e3181ec173d","article-title":"Receiver operating characteristic curve in diagnostic test assessment","volume":"5","author":"Mandrekar","year":"2010","journal-title":"J Thorac Oncol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/214\/12\/3283\/64202527\/vkaf226.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/214\/12\/3283\/64202527\/vkaf226.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T20:38:06Z","timestamp":1766522286000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/214\/12\/3283\/8247274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,3]]},"references-count":53,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,9,3]]},"published-print":{"date-parts":[[2025,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jimmun\/vkaf226","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,12]]},"published":{"date-parts":[[2025,9,3]]}}}