{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T20:41:43Z","timestamp":1769805703091,"version":"3.49.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"FAPEMIG\u2014Rede Mineira de Imunobiol\u00f3gicos"},{"name":"Rede Mineira de Mucosa e Pele"},{"name":"CAPES-Brazil"},{"DOI":"10.13039\/100014989","name":"Chan Zuckerberg Initiative","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100014989","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CNPq\u2014INCT-Vacinas"},{"name":"INCT Hepatologia 360o e INCT Mucosas e Pele"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["4R00HL153673-03"],"award-info":[{"award-number":["4R00HL153673-03"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The liver contains a diverse repertoire of leukocytes, with liver B cells representing a significant population of hepatic immune cells in both newborns and adults. Despite their importance, these cells remain largely unexplored. In this study, we comprehensively characterized liver B cells from newborns through adulthood in both humans and mice applying a combination of in vivo imaging, immunophenotyping, RNA sequencing, and cell transfer protocols to characterize hepatic B cell subtypes from birth to adulthood. We found that newborn liver B cell population are transcriptionally and phenotypically distinct from those in adults, with significant alterations in genes related to immunoglobulin processing, release, and major histocompatibility complex class I and II functions. Photoconversion-based tracking revealed that liver-resident B cells actively migrate to distant lymphoid organs, including the spleen and bone marrow, where they integrate into the mature immune cell pool. Our findings establish the newborn liver as a crucial niche for B cell maturation and migration, highlighting its role in seeding secondary lymphoid organs and contributing to immune function throughout life. These insights provide new understanding of liver-derived B cells in the postnatal development of the immune system.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf264","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T17:33:39Z","timestamp":1761413619000},"source":"Crossref","is-referenced-by-count":0,"title":["Postnatal liver B cell precursors contribute to the establishment of a mature B cell pool in secondary lymphoid organs in mice"],"prefix":"10.1093","volume":"215","author":[{"given":"Kassiana","family":"Mafra","sequence":"first","affiliation":[{"name":"Center for Gastrointestinal Biology, Departamento de Morfologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais , Belo Horizonte, Minas Gerais,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilia Garcia","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Ann Romney Center for Neurologic Diseases, Brigham and 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