{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T05:17:22Z","timestamp":1770268642124,"version":"3.49.0"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Health","award":["HL146479"],"award-info":[{"award-number":["HL146479"]}]},{"name":"National Institute of Health","award":["HL107380"],"award-info":[{"award-number":["HL107380"]}]},{"name":"National Institute of Health","award":["AI111914"],"award-info":[{"award-number":["AI111914"]}]},{"name":"University of Rochester Department of Medicine Funds"},{"DOI":"10.13039\/100012051","name":"Lupus Research Alliance","doi-asserted-by":"publisher","award":["975578"],"award-info":[{"award-number":["975578"]}],"id":[{"id":"10.13039\/100012051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003185","name":"National Psoriasis Foundation","doi-asserted-by":"publisher","award":["NPF851079"],"award-info":[{"award-number":["NPF851079"]}],"id":[{"id":"10.13039\/100003185","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Influenza is a significant public health and economic threat around the world. Although pneumonia is the most common complication associated with influenza, there are several clinical reports showing an increased risk for cardiovascular disease. Studies have shown that influenza infection correlates with increased incidence of myocardial infarction. Atherosclerosis is a common cause of coronary artery disease including myocardial infarction, stroke, and heart failure. Here, we analyzed the effect of influenza infection in high-fat diet\u2013induced atherosclerosis in Apoe\u2212\/\u2212 mice. We found increased weight loss and decreased survival, increased numbers of CD11b+Ly6C+ cells (inflammatory monocytes) and CD11b+Ly6G+ cells (neutrophils), increased levels of CCL3, CCL4, and CCL5, increased lung pathology, and increased atherosclerotic lesions in the aorta in influenza-infected Apoe\u2212\/\u2212 mice when compared to influenza-infected wild-type (WT) and control (PBS-treated) Apoe\u2212\/\u2212 mice. An increased percentage of ROR\u03b3t+ and IL-17+ cells were identified in influenza-infected Apoe\u2212\/\u2212 mice compared with influenza-infected WT mice and PBS-treated Apoe\u2212\/\u2212 mice. Bone marrow macrophages from influenza-infected Apoe\u2212\/\u2212 mice showed increased expression of Th17 polarizing cytokines. Influenza-infected Color-flu (Venus)\u2013positive cells were identified in inflammatory monocytes and neutrophils in the lungs, spleen, blood, aorta, and vascular endothelial cells. These results suggest that influenza infection increases arterial inflammation by directly infecting endothelial cells, and indirectly through recruitment of inflammatory monocytes and neutrophils. Increased Th17 responses in influenza-infected Apoe\u2212\/\u2212 mice may be a possible mechanism involved in increased lung pathology and exacerbation of high-fat diet\u2013induced atherosclerosis.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf276","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T21:02:17Z","timestamp":1761858137000},"source":"Crossref","is-referenced-by-count":1,"title":["Influenza infection exacerbates high-fat diet\u2013induced atherosclerosis in apolipoprotein gene\u2013deficient mice"],"prefix":"10.1093","volume":"215","author":[{"given":"Louis","family":"DeVito","sequence":"first","affiliation":[{"name":"Department of Pediatrics, UPMC Children\u2019s Hospital of Pittsburgh , Pittsburgh, PA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oviya S","family":"Mohanraj","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, UPMC Children\u2019s Hospital of Pittsburgh , Pittsburgh, PA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepa","family":"Debnath","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, UPMC Children\u2019s Hospital of Pittsburgh , Pittsburgh, PA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas J","family":"Constantinesco","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, UPMC Children\u2019s Hospital of Pittsburgh , Pittsburgh, PA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baskaran","family":"Chinnappan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, UPMC Children\u2019s Hospital of Pittsburgh , Pittsburgh, PA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sashwath","family":"Srikanth","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, UPMC Children\u2019s Hospital of Pittsburgh , Pittsburgh, PA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crystal","family":"Moras","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, UPMC Children\u2019s Hospital of Pittsburgh , Pittsburgh, PA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A","family":"Marinelli","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, UPMC Children\u2019s Hospital of Pittsburgh , Pittsburgh, PA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lacee J","family":"Richwalls","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, UPMC Children\u2019s Hospital of Pittsburgh , Pittsburgh, PA,","place":["United 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of Rochester , Rochester, NY,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9738-1182","authenticated-orcid":false,"given":"Javier","family":"Rangel-Moreno","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester , Rochester, NY,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F","family":"Alcorn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, UPMC Children\u2019s Hospital of Pittsburgh , Pittsburgh, PA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radha","family":"Gopal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, UPMC Children\u2019s Hospital of Pittsburgh , Pittsburgh, PA,","place":["United 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