{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:55:56Z","timestamp":1789678556358,"version":"4.0.1"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-175134"],"award-info":[{"award-number":["PJT-175134"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT- 195731"],"award-info":[{"award-number":["PJT- 195731"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing epidemic with limited therapeutic options. Interleukin (IL)-17A, a proinflammatory cytokine produced by both innate and adaptive immune cells, has been implicated in MASLD-related inflammation and fibrosis. Although many studies have focused on IL-17A-producing lymphocytes, the role of innate immune cells like neutrophils recruited in response to and capable of producing IL-17A, is less well-characterized. Additionally, neutrophil extracellular traps (NETs), are observed in different chronic liver diseases and correlate with disease severity. Here, we sought to determine the kinetics of IL-17A-producing neutrophils during MASLD-related fibrosis and examine the effect of IL-17 on NET formation, contributing as such to liver fibrosis. Using a mouse model of MASLD induced by high-fat diet (HFD) feeding for 15 or 30\u2009weeks (WK) and in vitro studies, we observed a significant increase in intrahepatic IL-17A-producing neutrophils and NET formation in mice fed the HFD for 30\u2009WK\u00a0as compared to mice on HFD for 15\u2009WK\u00a0or controls. NET formation was strongly associated with liver injury and advanced fibrosis. Importantly, treatment with IL-17A induced NET formation in isolated neutrophils. IL-17A-induced NETs activated hepatic stellate cells (HSCs), induced expression of fibrogenic genes, and enhanced their migration in a wound-healing assay. All these are critical processes in fibrosis development. In conclusion, our results suggest that IL-17A-producing neutrophils, via the triggering of NET formation, play a key profibrogenic role in MASLD.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf332","type":"journal-article","created":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T17:13:27Z","timestamp":1772385207000},"source":"Crossref","is-referenced-by-count":1,"title":["IL-17A-induced NETs are profibrogenic in mice with metabolic dysfunction-associated steatotic liver disease (MASLD)"],"prefix":"10.1093","volume":"215","author":[{"given":"Mohamed N","family":"Abdelnabi","sequence":"first","affiliation":[{"name":"Centre de Recherche du Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM) , Montr\u00e9al, QC H2X 0A9,","place":["Canada"]},{"name":"D\u00e9partement de microbiologie, infectiologie et immunologie, Facult\u00e9 de m\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montr\u00e9al, QC H3C 3J7,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Maali","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM) , Montr\u00e9al, QC H2X 0A9,","place":["Canada"]},{"name":"D\u00e9partement de microbiologie, infectiologie et immunologie, Facult\u00e9 de m\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montr\u00e9al, QC H3C 3J7,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afrooz","family":"Dabbaghizadeh","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM) , Montr\u00e9al, QC H2X 0A9,","place":["Canada"]},{"name":"D\u00e9partement de microbiologie, infectiologie et immunologie, Facult\u00e9 de m\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montr\u00e9al, QC H3C 3J7,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niloufar","family":"Mokariasl","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM) , Montr\u00e9al, QC H2X 0A9,","place":["Canada"]},{"name":"D\u00e9partement de microbiologie, infectiologie et immunologie, Facult\u00e9 de m\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montr\u00e9al, QC H3C 3J7,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Dion","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM) , Montr\u00e9al, QC H2X 0A9,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raya","family":"Yamak","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM) , Montr\u00e9al, QC H2X 0A9,","place":["Canada"]},{"name":"D\u00e9partement de microbiologie, infectiologie et immunologie, Facult\u00e9 de m\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montr\u00e9al, QC H3C 3J7,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Soucy","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM) , Montr\u00e9al, QC H2X 0A9,","place":["Canada"]},{"name":"D\u00e9partement de pathologie et biologie cellulaire, Facult\u00e9 de m\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montr\u00e9al, QC H3C 3J7,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada S","family":"Hassan","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM) , Montr\u00e9al, QC H2X 0A9,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8817-8238","authenticated-orcid":false,"given":"Naglaa H","family":"Shoukry","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM) , Montr\u00e9al, QC H2X 0A9,","place":["Canada"]},{"name":"D\u00e9partement de m\u00e9decine, Facult\u00e9 de m\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montr\u00e9al, QC H3C 3J7,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,1]]},"reference":[{"key":"2026030112132296000_vkaf332-B1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2026030112132296000_vkaf332-B2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/hep.29466","article-title":"Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease","volume":"67","author":"Estes","year":"2018","journal-title":"Hepatology (Baltimore, Md.)"},{"key":"2026030112132296000_vkaf332-B3","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev-pathol-012615-044224","article-title":"Nonalcoholic fatty liver disease: pathogenesis and disease spectrum","volume":"11","author":"Hardy","year":"2016","journal-title":"Ann Rev Pathol"},{"key":"2026030112132296000_vkaf332-B4","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.29367","article-title":"The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the study of liver diseases","volume":"67","author":"Chalasani","year":"2018","journal-title":"Hepatology (Baltimore, Md.)"},{"key":"2026030112132296000_vkaf332-B5","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1089\/ars.2014.6108","article-title":"Myeloperoxidase-hepatocyte-stellate cell cross talk promotes hepatocyte injury and fibrosis in experimental nonalcoholic steatohepatitis","volume":"23","author":"Pulli","year":"2015","journal-title":"Antioxid Redox Signal"},{"key":"2026030112132296000_vkaf332-B6","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJMoa2309000","article-title":"A phase 3, randomized, controlled trial of resmetirom in NASH with liver fibrosis","volume":"390","author":"Harrison","year":"2024","journal-title":"N Engl J Med"},{"key":"2026030112132296000_vkaf332-B7","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ni1261","article-title":"A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17","volume":"6","author":"Park","year":"2005","journal-title":"Nat Immunol"},{"key":"2026030112132296000_vkaf332-B8","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aar7754","article-title":"Type 3 cytokines IL-17A and IL-22 drive TGF-beta-dependent liver fibrosis","volume":"3","author":"Fabre","year":"2018","journal-title":"Sci Immunol"},{"key":"2026030112132296000_vkaf332-B9","doi-asserted-by":"crossref","first-page":"1437046","DOI":"10.3389\/fimmu.2024.1437046","article-title":"Role of the type 3 cytokines IL-17 and IL-22 in modulating metabolic dysfunction-associated steatotic liver disease","volume":"15","author":"Abdelnabi","year":"2024","journal-title":"Front Immunol"},{"key":"2026030112132296000_vkaf332-B10","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1084\/jem.183.6.2593","article-title":"T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines","volume":"183","author":"Fossiez","year":"1996","journal-title":"J Exp Med"},{"key":"2026030112132296000_vkaf332-B11","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/eji.201141737","article-title":"Macrophages participate in IL-17-mediated inflammation","volume":"42","author":"Barin","year":"2012","journal-title":"Eur J Immunol"},{"key":"2026030112132296000_vkaf332-B12","doi-asserted-by":"crossref","first-page":"154497","DOI":"10.1016\/j.cyto.2018.07.028","article-title":"Type 3 cytokines in liver fibrosis and liver cancer","volume":"124","author":"Molina","year":"2019","journal-title":"Cytokine"},{"key":"2026030112132296000_vkaf332-B13","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1146\/annurev-pathol-011110-130318","article-title":"The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin","volume":"8","author":"Weaver","year":"2013","journal-title":"Ann Re Pathol"},{"key":"2026030112132296000_vkaf332-B14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jaut.2008.03.006","article-title":"MPO-ANCA induces IL-17 production by activated neutrophils in vitro via classical complement pathway-dependent manner","volume":"31","author":"Hoshino","year":"2008","journal-title":"J Autoimmun"},{"key":"2026030112132296000_vkaf332-B15","doi-asserted-by":"crossref","first-page":"e39307","DOI":"10.1371\/journal.pone.0039307","article-title":"Significance of the balance between regulatory T (Treg) and T helper 17 (Th17) cells during hepatitis B virus related liver fibrosis","volume":"7","author":"Li","year":"2012","journal-title":"PLoS One"},{"key":"2026030112132296000_vkaf332-B16","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1007\/s10875-010-9416-3","article-title":"Involvement of Th17 and Th1 effector responses in patients with Hepatitis B","volume":"30","author":"Ye","year":"2010","journal-title":"J Clin Immunol"},{"key":"2026030112132296000_vkaf332-B17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-230X-12-43","article-title":"Changes of Treg and Th17 cells balance in the development of acute and chronic hepatitis B virus infection","volume":"12","author":"Xue-Song","year":"2012","journal-title":"BMC Gastroenterol"},{"key":"2026030112132296000_vkaf332-B18","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1111\/jgh.12653","article-title":"Randomized trial of autologous bone marrow mesenchymal stem cells transplantation for hepatitis B virus cirrhosis: regulation of Treg\/Th17 cells","volume":"29","author":"Xu","year":"2014","journal-title":"J Gastroenterol Hepatol"},{"key":"2026030112132296000_vkaf332-B19","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/jgh.12459","article-title":"Ratios of regulatory T cells\/T-helper 17 cells and transforming growth factor-\u03b21\/interleukin-17 to be associated with the development of hepatitis B virus-associated liver cirrhosis","volume":"29","author":"Yu","year":"2014","journal-title":"J Gastroenterol Hepatol"},{"key":"2026030112132296000_vkaf332-B20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1471-2172-12-47","article-title":"The balance between intrahepatic IL-17(+) T cells and Foxp3(+) regulatory T cells plays an important role in HBV-related end-stage liver disease","volume":"12","author":"Niu","year":"2011","journal-title":"BMC Immunol"},{"key":"2026030112132296000_vkaf332-B21","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1089\/vim.2010.0135","article-title":"The ratio of Th-17 to Treg cells is associated with survival of patients with acute-on-chronic hepatitis B liver failure","volume":"24","author":"Zhai","year":"2011","journal-title":"Viral Immunol"},{"key":"2026030112132296000_vkaf332-B22","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4049\/jimmunol.1501175","article-title":"Progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis is marked by a higher frequency of Th17 cells in the liver and an increased Th17\/resting regulatory T cell ratio in peripheral blood and in the liver","volume":"196","author":"Rau","year":"2016","journal-title":"J Immunol"},{"key":"2026030112132296000_vkaf332-B23","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1042\/CS20150405","article-title":"The balance between IL-17 and IL-22 produced by liver-infiltrating T-helper cells critically controls NASH development in mice","volume":"130","author":"Rolla","year":"2016","journal-title":"Clin Sci (Lond)"},{"key":"2026030112132296000_vkaf332-B24","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1365-2249.2011.04471.x","article-title":"Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease","volume":"166","author":"Tang","year":"2011","journal-title":"Clin Exp Immunol"},{"key":"2026030112132296000_vkaf332-B25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ccell.2016.05.020","article-title":"Metabolic inflammation-associated IL-17A causes non-alcoholic steatohepatitis and hepatocellular carcinoma","volume":"30","author":"Gomes","year":"2016","journal-title":"Cancer Cell"},{"key":"2026030112132296000_vkaf332-B26","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1053\/j.gastro.2012.05.049","article-title":"Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice","volume":"143","author":"Meng","year":"2012","journal-title":"Gastroenterology"},{"key":"2026030112132296000_vkaf332-B27","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.4049\/jimmunol.1203013","article-title":"IL-17A plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation","volume":"191","author":"Tan","year":"2013","journal-title":"J Immunol"},{"key":"2026030112132296000_vkaf332-B28","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/icb.2011.59","article-title":"Critical role of interleukin-17\/interleukin-17 receptor axis in mediating Con A-induced hepatitis","volume":"90","author":"Yan","year":"2012","journal-title":"Immunol Cell Biol"},{"key":"2026030112132296000_vkaf332-B29","doi-asserted-by":"crossref","first-page":"e18909","DOI":"10.1371\/journal.pone.0018909","article-title":"Interleukin-17 contributes to the pathogenesis of autoimmune hepatitis through inducing hepatic interleukin-6 expression","volume":"6","author":"Zhao","year":"2011","journal-title":"PLoS One"},{"key":"2026030112132296000_vkaf332-B30","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/hep.22680","article-title":"The interleukin-17 pathway is involved in human alcoholic liver disease","volume":"49","author":"Lemmers","year":"2009","journal-title":"Hepatology"},{"key":"2026030112132296000_vkaf332-B31","doi-asserted-by":"crossref","first-page":"751802","DOI":"10.3389\/fendo.2021.751802","article-title":"Role of neutrophils in the pathogenesis of nonalcoholic steatohepatitis","volume":"12","author":"Hwang","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026030112132296000_vkaf332-B32","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1111\/liv.13060","article-title":"Progression of fibrosis in patients with chronic viral hepatitis is associated with IL-17(+) neutrophils","volume":"36","author":"Macek Jilkova","year":"2016","journal-title":"Liver Int"},{"key":"2026030112132296000_vkaf332-B33","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/hep.29914","article-title":"Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in nonalcoholic steatohepatitis","volume":"68","author":"van der Windt","year":"2018","journal-title":"Hepatology"},{"key":"2026030112132296000_vkaf332-B34","first-page":"24","article-title":"Nonalcoholic fatty liver disease (NAFLD) severity is associated to a nonhemostatic contribution and proinflammatory phenotype of platelets","volume":"231","author":"Miele","year":"2021","journal-title":"Transl Res J Lab Clin Med"},{"key":"2026030112132296000_vkaf332-B35","doi-asserted-by":"crossref","first-page":"101697","DOI":"10.1016\/j.clinre.2021.101697","article-title":"Neutrophil extracellular traps induced by pro-inflammatory cytokines enhance procoagulant activity in NASH patients","volume":"46","author":"Du","year":"2022","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"2026030112132296000_vkaf332-B36","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.jhep.2021.07.032","article-title":"Regulatory T-cell and neutrophil extracellular trap interaction contributes to carcinogenesis in non-alcoholic steatohepatitis","volume":"75","author":"Wang","year":"2021","journal-title":"J Hepatol"},{"key":"2026030112132296000_vkaf332-B37","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41419-020-2582-1","article-title":"Neutrophils undergo switch of apoptosis to NETosis during murine fatty liver injury via S1P receptor 2 signaling","volume":"11","author":"Zhao","year":"2020","journal-title":"Cell Death Dis"},{"key":"2026030112132296000_vkaf332-B38","doi-asserted-by":"crossref","first-page":"268","DOI":"10.4049\/jimmunol.1800454","article-title":"Computational analysis supports IL-17A as a central driver of neutrophil extracellular trap-mediated injury in liver ischemia reperfusion","volume":"202","author":"Tohme","year":"2019","journal-title":"J Immunol (Baltimore, Md.: 1950)"},{"key":"2026030112132296000_vkaf332-B39","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.jcmgh.2022.08.001","article-title":"Sex-dependent hepatoprotective role of IL-22 receptor signaling in non-alcoholic fatty liver disease-related fibrosis","volume":"14","author":"Abdelnabi","year":"2022","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"2026030112132296000_vkaf332-B40","doi-asserted-by":"crossref","DOI":"10.3791\/60740","article-title":"Visualization, quantification, and mapping of immune cell populations in the tumor microenvironment","author":"Flores Molina","year":"2020","journal-title":"J Vis Exp"},{"key":"2026030112132296000_vkaf332-B41","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12575-018-0072-y","article-title":"DNA area and NETosis analysis (DANA): a high-throughput method to quantify neutrophil extracellular traps in fluorescent microscope images","volume":"20","author":"Rebernick","year":"2018","journal-title":"Biol Proc Online"},{"key":"2026030112132296000_vkaf332-B42","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3389\/fimmu.2013.00166","article-title":"An improved strategy to recover large fragments of functional human neutrophil extracellular traps","volume":"4","author":"Barrientos","year":"2013","journal-title":"Front Immunol"},{"key":"2026030112132296000_vkaf332-B43","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.4049\/jimmunol.1400861","article-title":"IL-17A enhances the expression of profibrotic genes through upregulation of the TGF-beta receptor on hepatic stellate cells in a JNK-dependent manner","volume":"193","author":"Fabre","year":"2014","journal-title":"J Immunol"},{"key":"2026030112132296000_vkaf332-B44","doi-asserted-by":"crossref","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci Rep"},{"key":"2026030112132296000_vkaf332-B45","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1097\/HEP.0000000000000762","article-title":"Neutrophil extracellular traps promote MASH fibrosis by metabolic reprogramming of HSC","volume":"81","author":"Xia","year":"2025","journal-title":"Hepatology (Baltimore, Md.)"},{"key":"2026030112132296000_vkaf332-B46","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aal3694","article-title":"Type 2 immunity is protective in metabolic disease but exacerbates NAFLD collaboratively with TGF-\u03b2","volume":"9","author":"Hart","year":"2017","journal-title":"Sci Transl Med"},{"key":"2026030112132296000_vkaf332-B47","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-pathol-011110-130246","article-title":"Pathogenesis of liver fibrosis","volume":"6","author":"Hernandez-Gea","year":"2011","journal-title":"Ann Rev Pathol"},{"key":"2026030112132296000_vkaf332-B48","doi-asserted-by":"crossref","first-page":"490","DOI":"10.4049\/jimmunol.1100123","article-title":"Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis","volume":"187","author":"Lin","year":"2011","journal-title":"J Immunol"},{"key":"2026030112132296000_vkaf332-B49","doi-asserted-by":"crossref","first-page":"9448","DOI":"10.1073\/pnas.1201840109","article-title":"Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis","volume":"109","author":"Kisseleva","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026030112132296000_vkaf332-B50","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.clim.2016.03.016","article-title":"Neutrophils from F508del cystic fibrosis patients produce IL-17A and express IL-23 - dependent IL-17RC","volume":"170","author":"Taylor","year":"2016","journal-title":"Clin Immunol (Orlando, Fla.)"},{"key":"2026030112132296000_vkaf332-B51","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/path.4359","article-title":"Neutrophil extracellular traps promote differentiation and function of fibroblasts","volume":"233","author":"Chrysanthopoulou","year":"2014","journal-title":"J Pathol"},{"key":"2026030112132296000_vkaf332-B52","doi-asserted-by":"crossref","first-page":"15265","DOI":"10.1038\/ncomms15265","article-title":"The microbiota maintain homeostasis of liver-resident \u03b3\u03b4T-17 cells in a lipid antigen\/CD1d-dependent manner","volume":"8","author":"Li","year":"2017","journal-title":"Nat Commun"},{"key":"2026030112132296000_vkaf332-B53","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/s41467-022-28172-4","article-title":"Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2","volume":"13","author":"Wilson","year":"2022","journal-title":"Nat Commun"},{"key":"2026030112132296000_vkaf332-B54","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00428-022-03330-7","article-title":"Neutrophil extracellular traps enriched with IL-1\u03b2 and IL-17A participate in the hepatic inflammatory process of patients with non-alcoholic steatohepatitis","volume":"481","author":"Arelaki","year":"2022","journal-title":"Virchows Archiv Int J Pathol"},{"key":"2026030112132296000_vkaf332-B55","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"2026030112132296000_vkaf332-B56","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jhep.2017.09.010","article-title":"IL-33 exacerbates liver sterile inflammation by amplifying neutrophil extracellular trap formation","volume":"68","author":"Yazdani","year":"2018","journal-title":"J Hepatol"},{"key":"2026030112132296000_vkaf332-B57","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2026030112132296000_vkaf332-B58","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41420-024-01995-4","article-title":"IL-17a promotes hepatocellular carcinoma by increasing FAP expression in hepatic stellate cells via activation of the STAT3 signaling pathway","volume":"10","author":"Sun","year":"2024","journal-title":"Cell Death Discov"},{"key":"2026030112132296000_vkaf332-B59","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1002\/eji.202048878","article-title":"IL-17A expressed on neutrophil extracellular traps promotes mesenchymal stem cell differentiation toward bone-forming cells in ankylosing spondylitis","volume":"51","author":"Papagoras","year":"2021","journal-title":"Eur J Immunol"},{"key":"2026030112132296000_vkaf332-B60","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1136\/gutjnl-2023-331447","article-title":"Neutrophil extracellular traps activate hepatic stellate cells and monocytes via NLRP3 sensing in alcohol-induced acceleration of MASH fibrosis","volume":"73","author":"Babuta","year":"2024","journal-title":"Gut"},{"key":"2026030112132296000_vkaf332-B61","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1186\/s12964-024-01944-9","article-title":"Neutrophil extracellular traps facilitate liver inflammation\/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis","volume":"22","author":"Zhang","year":"2024","journal-title":"Cell Commun Signal"},{"key":"2026030112132296000_vkaf332-B62","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/mi.2016.80","article-title":"IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria","volume":"10","author":"Flannigan","year":"2017","journal-title":"Mucosal Immunol"},{"key":"2026030112132296000_vkaf332-B63","doi-asserted-by":"crossref","first-page":"1279837","DOI":"10.3389\/fimmu.2023.1279837","article-title":"Interactions between neutrophils and T-helper 17 cells","volume":"14","author":"Fan","year":"2023","journal-title":"Front Immunol"},{"key":"2026030112132296000_vkaf332-B64","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ebiom.2017.08.001","article-title":"IL-17 production of neutrophils enhances antibacteria ability but promotes arthritis development during mycobacterium tuberculosis infection","volume":"23","author":"Hu","year":"2017","journal-title":"EBioMedicine"},{"key":"2026030112132296000_vkaf332-B65","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/ni.2797","article-title":"Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, ROR\u03b3t and dectin-2","volume":"15","author":"Taylor","year":"2014","journal-title":"Nat Immunol"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/215\/2\/vkaf332\/67188809\/vkaf332.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/215\/2\/vkaf332\/67188809\/vkaf332.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T17:13:34Z","timestamp":1772385214000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/doi\/10.1093\/jimmun\/vkaf332\/8502613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,9]]}},"URL":"https:\/\/doi.org\/10.1093\/jimmun\/vkaf332","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,2]]},"published":{"date-parts":[[2026,2]]},"article-number":"vkaf332"}}