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Further identification and characterization of factors that may play a role within the BCL6 network is important for our understanding of GC B cell differentiation and function. Here, through co-Immunoprecipitation coupled with mass spectrometry, we identify CHAF1B as a new partner in the BCL6 complex, which is highly expressed in GC B cells, promoting GC formation and humoral immunity. Loss of CHAF1B impairs the dark zone (DZ) and light zone (LZ) organization and induces apoptosis, resulting in abnormal GC responses and antibody production. Mechanistically, CHAF1B stabilizes BCL6\/TBL1XR1 complex to promote GC B cell differentiation by cooperative transcriptional repression. Furthermore, overexpression of CHAF1B in B cells reduces the plasmablast by extending GC reaction, which is positively related to the production of high affinity antibodies in response to vaccines or pathogens. These findings not only advance the understanding of GC biology but also had potential implications for developing targeted strategies to improve vaccination efficacy.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf339","type":"journal-article","created":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T17:13:35Z","timestamp":1772385215000},"source":"Crossref","is-referenced-by-count":0,"title":["Histone chaperone CHAF1B facilitates germinal center B cell differentiation via cooperation with BCL6 and TBL1XR1"],"prefix":"10.1093","volume":"215","author":[{"given":"Achun","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Human Virology, Department of Pathogen Biology and Biosecurity, and Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University , Guangzhou, 510080,","place":["China"]},{"name":"Guangdong Province Key Laboratory of Pharmaceutical Bioactive Substances, School of Life Sciences and 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510080,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayi","family":"Yuan","sequence":"additional","affiliation":[{"name":"Institute of Human Virology, Department of Pathogen Biology and Biosecurity, and Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University , Guangzhou, 510080,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingtong","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Human Virology, Department of Pathogen Biology and Biosecurity, and Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University , Guangzhou, 510080,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiancai","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Human Virology, Department of Pathogen Biology and Biosecurity, and Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University , Guangzhou, 510080,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Human Virology, Department of Pathogen Biology and Biosecurity, and Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University , Guangzhou, 510080,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Eighth Affiliated Hospital of Sun Yat-sen University , Shen Zhen,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junchao","family":"Dong","sequence":"additional","affiliation":[{"name":"Institute of Human Virology, Department of Pathogen Biology and Biosecurity, and Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University , Guangzhou, 510080,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Human Virology, Department of Pathogen Biology and Biosecurity, and Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University , Guangzhou, 510080,","place":["China"]},{"name":"Center for Infection and Immunity Study, School of Medicine, Sun Yat-sen University , Shenzhen,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Human Virology, Department of Pathogen Biology and Biosecurity, and Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen 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