{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:21:05Z","timestamp":1787030465417,"version":"build-2736575974"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01AI129945"],"award-info":[{"award-number":["R01AI129945"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Research, Innovation & Impact (RII) of the University of Arizona and National Cancer Institute","award":["P30CA023074"],"award-info":[{"award-number":["P30CA023074"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["S10 OD028466"],"award-info":[{"award-number":["S10 OD028466"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Plasma cell subsets vary in their lifespans and ability to sustain humoral immunity. We conducted a genome-wide CRISPR-Cas9 screen in myeloma cells for factors that promote surface expression of CD98, a marker of longevity in mouse plasma cells. A large fraction of genes found to promote CD98 expression in this screen are involved in secretory and other vesicles, including subunits of the V-type ATPase complex. Genetic ablation and chemical inhibition of V-type ATPases in myeloma cells and primary plasma cells, respectively, reduced antibody secretion. Mouse and human long-lived plasma cells had greater numbers of acidified vesicles than their short-lived counterparts, and this correlated with increased antibody secretory capacity. The screen also revealed a requirement for the signaling adapter MYD88 in CD98 expression. Plasma cell\u2013specific deletion of Myd88 led to reduced survival and antibody secretion by antigen-specific cells in vivo and unresponsiveness to BAFF and APRIL ex vivo. These data reveal novel regulators that link plasma cell secretory capacity and lifespan.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf354","type":"journal-article","created":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T17:13:35Z","timestamp":1772385215000},"source":"Crossref","is-referenced-by-count":4,"title":["A genome-wide CRISPR screen reveals novel determinants of long-lived plasma cell secretory capacity"],"prefix":"10.1093","volume":"215","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4132-7328","authenticated-orcid":false,"given":"Lucas J","family":"D\u2019Souza","sequence":"first","affiliation":[{"name":"Department of Immunobiology, University of Arizona , Tucson, AZ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan N","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, University of Arizona , Tucson, AZ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Coffman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, University of Arizona , Tucson, AZ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward P","family":"Petrow","sequence":"additional","affiliation":[{"name":"Tucson Orthopedic Institute , Tucson, AZ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8377-7699","authenticated-orcid":false,"given":"Deepta","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, University of Arizona , Tucson, AZ,","place":["United 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