{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T17:56:33Z","timestamp":1772387793893,"version":"3.50.1"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Ruth L. Kirschstein National Research Service Award Fellowship from the National Heart, Lung, and Blood Institute","award":["R35 GM118027"],"award-info":[{"award-number":["R35 GM118027"]}]},{"name":"Ruth L. Kirschstein National Research Service Award Fellowship from the National Heart, Lung, and Blood Institute","award":["1F30HL174128"],"award-info":[{"award-number":["1F30HL174128"]}]},{"name":"University of Wisconsin Carbone Cancer Center Support Grant","award":["P30 CA014520"],"award-info":[{"award-number":["P30 CA014520"]}]},{"name":"University of Wisconsin\u2013Madison Biotechnology Gene Expression Center","award":["SCR_017757"],"award-info":[{"award-number":["SCR_017757"]}]},{"name":"DNA Sequencing Facility","award":["SCR_017759"],"award-info":[{"award-number":["SCR_017759"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neutrophils are necessary for host defense but also contribute to tissue damage. Understanding the molecular mechanisms that govern human neutrophil development and fate is critical for developing interventions for treating and preventing human disease. Human induced pluripotent stem cell (iPSC)\u2013derived neutrophils (iNeutrophils) are genetically tractable and provide a robust source of neutrophils to dissect molecular regulation and for potential use in infusion therapies. Here, we show that deletion of the paracrine factor myeloid-derived growth factor (MYDGF) in human iPSCs results in the development of iNeutrophils with improved zymosan-induced reactive oxygen species generation and antimicrobial functions. MYDGF-deficient iNeutrophils showed improved transendothelial migration to microbes in organotypic models and motility in confined microchannels. We identify MYDGF as a new endogenous inhibitor of cytosolic calcium dynamics that suppresses neutrophil inflammatory activity. Our findings show that MYDGF mediates neutrophil-to-neutrophil communication during migration through a paracrine mechanism. Since MYDGF-deficient iNeutrophils show improved effector and antimicrobial function, these cells may improve future therapeutic use of iNeutrophils for infusion therapies. Finally, soluble MYDGF provides an attractive strategy to limit chronic neutrophil-mediated inflammation and tissue damage.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf364","type":"journal-article","created":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T17:13:36Z","timestamp":1772385216000},"source":"Crossref","is-referenced-by-count":0,"title":["The paracrine factor myeloid derived growth factor regulates the inflammatory fate and motility of human induced pluripotent stem cell\u2013derived neutrophils"],"prefix":"10.1093","volume":"215","author":[{"given":"Frances M","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin\u2013Madison , Madison, WI,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan H","family":"Schrope","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin\u2013Madison , Madison, WI,","place":["United States"]},{"name":"Department of Pathology and Laboratory Medicine, University of Wisconsin\u2013Madison , Madison, WI,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A","family":"Bennin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Wisconsin\u2013Madison , Madison, WI,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Horn","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin\u2013Madison , Madison, WI,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew S","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin\u2013Madison , Madison, WI,","place":["United States"]},{"name":"Department of Biological Sciences, Bowling Green State University , Bowling Green, OH,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiran","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin\u2013Madison , Madison, WI,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack J","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Wisconsin\u2013Madison , Madison, WI,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgan A","family":"Giese","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin\u2013Madison , Madison, WI,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3307-1126","authenticated-orcid":false,"given":"Huy Q","family":"Dinh","sequence":"additional","affiliation":[{"name":"Department of Oncology, University of Wisconsin\u2013Madison , Madison, WI,","place":["United States"]},{"name":"Department of Biostatistics and Medical Informatics, University of Wisconsin\u2013Madison , Madison, WI,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7940-6254","authenticated-orcid":false,"given":"Anna","family":"Huttenlocher","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin\u2013Madison , Madison, WI,","place":["United States"]},{"name":"Department of Pediatrics, University of Wisconsin\u2013Madison , Madison, WI,","place":["United 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