{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T17:56:30Z","timestamp":1772387790519,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Vascular Cures Foundation"},{"DOI":"10.13039\/100011252","name":"Lefkofsky Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011252","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Elizabeth Anne Baiardi Research Fund"},{"name":"University of Michigan Cardiovascular Center COVID"},{"name":"National Institutes of Health National Heart, Lung, and Blood Institute","award":["1K08HL155408"],"award-info":[{"award-number":["1K08HL155408"]}]},{"name":"National Institutes of Health National Heart, Lung, and Blood Institute","award":["1R01HL171135"],"award-info":[{"award-number":["1R01HL171135"]}]},{"name":"National Institutes of Health National Heart, Lung, and Blood Institute","award":["1R35HL176572"],"award-info":[{"award-number":["1R35HL176572"]}]},{"name":"National Institutes of Health National Heart, Lung, and Blood Institute","award":["5R35HL167143"],"award-info":[{"award-number":["5R35HL167143"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Urokinase (uPA) and urokinase plasminogen activator receptor (uPAR\/PLAUR) mediate fibrinolysis and matrix remodeling. Liberation of monocyte\/macrophage (MO\/M\u03c6)-bound soluble uPAR (suPAR) occurs after infection with coronaviruses (CoVs) such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), correlating with systemic inflammatory stress and end-organ injury severity. How suPAR liberation from MO\/M\u03c6s occurs after CoV infection, and whether suPAR induction is exclusive to coronavirus infection or occurs from other clinically significant coagulopathy-inducing pneumotropic viral infections such as influenza A (IAV), is unknown. We noted increased PLAUR transcripts in peripheral blood mononuclear cells (PBMCs) from SARS-CoV-2-positive and IAV-positive patients. Elevated suPAR liberation was observed after murine CoV infection but not IAV infection\u2014both of which led to increased MO\/M\u03c6 mRNA and cell-bound uPA and uPAR, and increased secreted uPA activity. uPA knockdown in MO\/M\u03c6s abrogated suPAR liberation and blunted tumor necrosis factor (TNF)-\u03b1, interleukin (IL)-1\u03b2, and IL-6 induction post-CoV, suggesting that targeting co-regulators of uPAR and uPA may be beneficial in attenuating coronavirus-driven inflammatory cytokine responses, and treating diseases characterized by suPAR release from M\u03c6s.<\/jats:p>","DOI":"10.1093\/jimmun\/vkaf365","type":"journal-article","created":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T17:13:23Z","timestamp":1772385203000},"source":"Crossref","is-referenced-by-count":0,"title":["Viral-specific induction of cellular and soluble urokinase plasminogen activator receptor (suPAR) expression"],"prefix":"10.1093","volume":"215","author":[{"given":"Sriganesh B","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of General Surgery, University of Michigan , Ann Arbor, MI,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4771-475X","authenticated-orcid":false,"given":"Kiran","family":"Kumar","sequence":"additional","affiliation":[{"name":"Section of Vascular Surgery, University of Michigan , Ann Arbor, MI,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathaniel","family":"Parchment","sequence":"additional","affiliation":[{"name":"Section of Vascular Surgery, University of Michigan , Ann Arbor, MI,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevin","family":"Eggleston","sequence":"additional","affiliation":[{"name":"Section of Vascular Surgery, University of Michigan , Ann Arbor, MI,","place":["United 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