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Its role in mature B cell biology and associated malignancies is unknown. Here, by using a conditional mouse model for specific deletion in activated B cells, we demonstrate that HDAC7 is essential for the formation of germinal centers (GC). HDAC7 deficiency results in the generation of aberrant GCB cells, diminished class switch recombination (CSR) and plasma cell (PC) formation. We demonstrate that low expression of HDAC7 in diffuse large B cell lymphoma (DLBCL) tumors is associated with poor prognosis of the patients. Importantly, expression of HDAC7 in DLBCL cell lines reduces the proliferative capacity, as well as DLBCL tumorigenicity in vivo. In summary, our data revealed first, the important function of HDAC7 in the establishment of the GC, and second, the potential contribution of HDAC7 deregulation in DLBCL.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag015","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:56:15Z","timestamp":1773827775000},"source":"Crossref","is-referenced-by-count":0,"title":["HDAC7 is a key factor for the germinal center reaction and its underexpression is associated with DLBCL prognosis"],"prefix":"10.1093","volume":"215","author":[{"given":"Ainara","family":"Meler","sequence":"first","affiliation":[{"name":"Lymphocyte Development and Disease Group, Josep Carreras Leukaemia Research Institute , Badalona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Gusi-Vives","sequence":"additional","affiliation":[{"name":"Lymphocyte Development and Disease Group, Josep Carreras Leukaemia Research Institute , Badalona,","place":["Spain"]},{"name":"Doctoral Program in Biomedicine, Universitat de Barcelona (UB), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriol","family":"de Barrios","sequence":"additional","affiliation":[{"name":"Lymphocyte Development and Disease Group, Josep Carreras Leukaemia Research Institute , Badalona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Azagra","sequence":"additional","affiliation":[{"name":"Lymphocyte Development and Disease Group, Josep Carreras Leukaemia Research Institute , Badalona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Collazo","sequence":"additional","affiliation":[{"name":"Lymphocyte Development and Disease Group, Josep Carreras Leukaemia Research Institute , Badalona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Melchor","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Genetics, University of Navarra , Pamplona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Del Monte-Monge","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares, B Cell Biology Laboratory , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"Gy\u0151rffy","sequence":"additional","affiliation":[{"name":"Cancer Biomarker Research Group, TTK , Budapest,","place":["Hungary"]},{"name":"Department of Bioinformatics and Department of Pediatrics, Semmelweis University , Budapest,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Verdu-Bou","sequence":"additional","affiliation":[{"name":"Lymphoid Neoplasms Group, Josep Carreras Leukaemia Research Institute , Badalona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9-Tom\u00e1s","family":"Navarro","sequence":"additional","affiliation":[{"name":"Lymphoid Neoplasms Group, Josep Carreras Leukaemia Research Institute , Badalona,","place":["Spain"]},{"name":"Department of Hematology, Institut Catal\u00e0 d\u2018Oncologia-Germans Trias i Pujol Hospital , Badalona,","place":["Spain"]},{"name":"Department of Medicine, Universitat Aut\u00f2noma de Barcelona , Badalona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Ignacio","family":"Mart\u00edn-Subero","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) and University of Barcelona , Barcelona,","place":["Spain"]},{"name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA) , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00ebl","family":"Rou\u00e9","sequence":"additional","affiliation":[{"name":"Lymphoma Translational Group, UBIRed, Josep Carreras Leukaemia Research Institute , Badalona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almudena R","family":"Ramiro","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares, B Cell Biology Laboratory , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Roa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Genetics, University of Navarra , Pamplona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9072-5763","authenticated-orcid":false,"given":"Maribel","family":"Parra","sequence":"additional","affiliation":[{"name":"Lymphocyte Development and Disease Group, Josep Carreras Leukaemia Research Institute , Badalona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"2026060502511901300_vkag015-B1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.immuni.2016.09.001","article-title":"Germinal center B Cell dynamics","volume":"45","author":"Mesin","year":"2016","journal-title":"Immunity"},{"key":"2026060502511901300_vkag015-B2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev-immunol-120419-022408","article-title":"Germinal centers","volume":"40","author":"Victora","year":"2022","journal-title":"Annu Rev 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