{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T19:55:50Z","timestamp":1781726150709,"version":"3.54.5"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI124693"],"award-info":[{"award-number":["R01AI124693"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI172140"],"award-info":[{"award-number":["R21AI172140"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI157440"],"award-info":[{"award-number":["R21AI157440"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007812","name":"University of Washington","doi-asserted-by":"publisher","award":["T32AR007108"],"award-info":[{"award-number":["T32AR007108"]}],"id":[{"id":"10.13039\/100007812","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>T cell immunity depends on the precise coordination of signaling networks with actin cytoskeleton remodeling, yet the molecular regulators of these processes remain incompletely defined. Flightless-1 (FLII) is a gelsolin-family actin regulator with unique leucine-rich repeats that can couple cytoskeletal dynamics to diverse signaling pathways. Here, using conditional knockout mice, we identify essential roles for FLII in both CD8+ and regulatory T cells. Loss of FLII in CD8+ T cells caused a profound loss of naive cells from the spleen, impaired CCR7-dependent migration, and defective accumulation in the lung parenchyma during antigen-specific responses to respiratory vesicular stomatitis virus infection, despite largely preserved activation, effector differentiation, and cytotoxic function. FLII-deficient Foxp3+ regulatory T cells maintained normal numbers but exhibited diminished CD25 expression, defective interleukin (IL)-2 signaling and failed to restrain spontaneous, tissue-specific autoimmunity. These findings identify FLII as a critical and previously unrecognized orchestrator of T cell trafficking and immune regulation, which may link chemokine receptor signaling to actin remodeling and is essential for proper T cell migration and function.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag019","type":"journal-article","created":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T19:04:09Z","timestamp":1776625449000},"source":"Crossref","is-referenced-by-count":0,"title":["Loss of the actin remodeling protein Flightless-1 impairs CD8 and regulatory T cell function"],"prefix":"10.1093","volume":"215","author":[{"given":"Michelle M","family":"Lissner","sequence":"first","affiliation":[{"name":"Center for Fundamental Immunology, Benaroya Research Institute , Seattle, WA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna M","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Center for Fundamental Immunology, Benaroya Research Institute , Seattle, WA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjian","family":"Ni","sequence":"additional","affiliation":[{"name":"Center for Fundamental Immunology, Benaroya Research Institute , Seattle, WA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"McKenna","family":"Sherve","sequence":"additional","affiliation":[{"name":"Center for Fundamental Immunology, Benaroya Research Institute , Seattle, WA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M","family":"Hocking","sequence":"additional","affiliation":[{"name":"Center for Fundamental Immunology, Benaroya Research Institute , Seattle, WA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A","family":"Hamerman","sequence":"additional","affiliation":[{"name":"Center for Fundamental Immunology, Benaroya Research Institute , Seattle, WA,","place":["United States"]},{"name":"Department of Immunology, University of Washington , Seattle, WA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9652-7178","authenticated-orcid":false,"given":"Daniel J","family":"Campbell","sequence":"additional","affiliation":[{"name":"Center for Fundamental Immunology, Benaroya Research Institute , Seattle, WA,","place":["United States"]},{"name":"Department of Immunology, University of Washington , Seattle, WA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,19]]},"reference":[{"key":"2026061715311621800_vkag019-B1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev.immunol.26.021607.090347","article-title":"The actin cytoskeleton in T cell activation","volume":"26","author":"Burkhardt","year":"2008","journal-title":"Annu Rev 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Immunol"},{"key":"2026061715311621800_vkag019-B8","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1006\/geno.1999.5817","article-title":"Novel proteins interacting with the leucine-rich repeat domain of human Flightless-I identified by the yeast two-hybrid system","volume":"58","author":"Fong","year":"1999","journal-title":"Genomics"},{"key":"2026061715311621800_vkag019-B9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1006\/bbrc.1999.0420","article-title":"Characterization of a novel Ras-binding protein Ce-FLI-1 comprising leucine-rich repeats and gelsolin-like domains","volume":"257","author":"Goshima","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"2026061715311621800_vkag019-B10","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aau0615","article-title":"The signaling adaptor BCAP inhibits NLRP3 and NLRC4 inflammasome activation in macrophages through interactions with 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