{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T05:49:07Z","timestamp":1792388947175,"version":"4.4.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01-AI125247"],"award-info":[{"award-number":["R01-AI125247"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Co-inhibitory receptors are essential checkpoints to restrain excessive T cell activation. While PD1 and CTLA4 have been extensively studied, the biology of lymphocyte activation gene 3 (Lag3), an emerging target for checkpoint blockade immunotherapy, remains less understood. In this study, we show that Lag3, though largely intracellular in resting T cells, exhibits unexpected dynamic cycling even without stimulation. The Lag3 cycling are influenced by lineage and differentiation status, particularly within memory and regulatory T cell subsets. Moreover, Lag3-like cycling patterns were also observed in other co-receptors with stimulatory and inhibitory properties. Mechanistically, endosomal trafficking is important for Lag3 cycling, whereas the cytoplasmic domain of Lag3 appears to be largely dispensable for this process. T cells engaging in Lag3 cycling exhibit a survival and proliferation advantage in both lymphpenic and lymphoreplete conditions. Together, these findings establish Lag3 cycling as a regulated and functionally important process, providing new insights into the biology of Lag3 in T cells.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag039","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T19:33:01Z","timestamp":1774726381000},"source":"Crossref","is-referenced-by-count":0,"title":["Activation and lineage specific Lag3 expression dynamics in T cells"],"prefix":"10.1093","volume":"215","author":[{"given":"Chaimae","family":"Khaled","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine , Chicago, IL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine , Chicago, IL,","place":["United 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