{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:00:23Z","timestamp":1788454823650,"version":"build-2803163510"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":43,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pseudomonas aeruginosa (Pa) is an opportunistic pathogen threatening individuals with obesity, a condition associated with chronic meta-inflammation and altered immunity. In this study, we evaluate the immunogenicity and protective efficacy of a nanoemulsion-based subunit vaccine (L-PaF\/ME\/BECC) targeting Pa in a diet-induced obese mouse model. Mice fed a high-fat diet (HFD; 60% fat) were compared to those on a low-fat diet (LFD; 10% fat) or regular chow (3% to 4% fat) to assess differences in vaccine responsiveness. Our results show that while L-PaF induces robust immune responses across all groups, HFD-fed mice exhibit significantly impaired antibody quality, including reduced IgA, IgG1, and IgG3 titers. These deficiencies were associated with impaired germinal center B-cell and T follicular helper cell responses, along with reduced CXCR5 and PD-1 modulation. In contrast, LFD-fed mice displayed preserved germinal center architecture and enhanced class-switched antibody production. This immune impairment extended to the lung-resident memory B cell in HFD mice, whereas LFD mice maintained a functional response. Despite compromised humoral immunity, HFD mice showed an expansion of lung tissue-resident memory T (Trm) cells postvaccination. FTY720 treatment showed that early secondary protection against Pa was maintained in the absence of circulating T-cell recruitment, consistent with a dominant contribution of lung-resident immune mechanisms during this early recall phase. Together, these findings suggest that lung Trm-associated immunity may partially compensate for obesity-associated defects in humoral responses and highlight the importance of vaccine strategies that promote tissue-localized T-cell immunity in metabolically compromised hosts.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag052","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T22:48:03Z","timestamp":1776120483000},"source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness and immunogenicity of a nanoemulsion protein subunit vaccine against\n                    <i>Pseudomonas aeruginosa<\/i>\n                    : investigation in diet-induced obese mice"],"prefix":"10.1093","volume":"215","author":[{"given":"Satabdi","family":"Biswas","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathobiology and Integrative Biomedical Sciences, University of Missouri , Columbia, MO 65201,","place":["United States"]},{"name":"Bond Life 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University of Missouri , Columbia, MO 65201,","place":["United States"]},{"name":"Bond Life Sciences Center, University of Missouri , Columbia, MO 65201,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K","family":"Ernst","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis, University of Maryland , Baltimore, MD 21201,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D","family":"Picking","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology and Integrative Biomedical Sciences, University of Missouri , Columbia, MO 65201,","place":["United States"]},{"name":"Bond Life Sciences Center, University of Missouri , Columbia, MO 65201,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7998-0643","authenticated-orcid":false,"given":"Wendy 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