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However, the specific T cell subtype that is the primary contributor to arterial aging is unknown. There is substantial evidence that CD8+ T cells are more susceptible to the effects of aging compared with their CD4+ counterparts. We hypothesized that CD8+ T cell\u2013specific depletion would ameliorate large-artery stiffness and augment endothelium-dependent dilation in old mice but not in young mice. We observed that old mice exhibited a greater accumulation of CD8+, but not CD4+, T cells in the aorta and mesentery compared with their young counterparts. Further, pharmacological depletion of CD8+, but not CD4+, T cells resulted in lower aortic stiffness and blunted aortic collagen. In addition, old CD8+, but not CD4+, depleted mice demonstrated augmented endothelium-dependent dilation via greater nitric oxide bioavailability. These data indicate that CD8+ T cells are the specific T cell subtype that contributes to age-related arterial dysfunction.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag060","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T02:30:12Z","timestamp":1776306612000},"source":"Crossref","is-referenced-by-count":1,"title":["CD8+ T cells contribute to arterial aging in mice"],"prefix":"10.1093","volume":"215","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0145-8764","authenticated-orcid":false,"given":"David J","family":"Buckley","sequence":"first","affiliation":[{"name":"Department of Kinesiology, College of Nursing and Health Innovation, The University of Texas at Arlington , Arlington, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sogol","family":"Zahedi","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, College of Nursing and Health Innovation, The University of Texas at Arlington , Arlington, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Canizales","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, College of Nursing and Health Innovation, The University of Texas at Arlington , Arlington, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan E","family":"Cuellar","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, College of Nursing and Health Innovation, The University of Texas at Arlington , Arlington, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kidist","family":"Bogale","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, College of Nursing and Health Innovation, The University of Texas at Arlington , Arlington, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, College of Nursing and Health Innovation, The University of Texas at Arlington , Arlington, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konner J","family":"Terrebonne","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, College of Nursing and Health Innovation, The University of Texas at Arlington , Arlington, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, College of Nursing and Health Innovation, The University of Texas at Arlington , Arlington, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blessy","family":"Joseph","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, College of Nursing and Health Innovation, The University of Texas at Arlington , Arlington, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jody L","family":"Greaney","sequence":"additional","affiliation":[{"name":"Department of Health Behavior and Nutrition Sciences, University of Delaware , Newark, DE,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W","family":"Trott","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, College of Nursing and Health Innovation, The University of Texas at Arlington , Arlington, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"2026073113114731300_vkag060-B1","doi-asserted-by":"publisher","first-page":"e93","DOI":"10.1161\/CIR.0000000000001123","article-title":"Heart Disease and Stroke Statistics-2023 update: a report from the American Heart Association","volume":"147","author":"Tsao","year":"2023","journal-title":"Circulation"},{"key":"2026073113114731300_vkag060-B2","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1161\/01.CIR.0000048892.83521.58","article-title":"Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises","volume":"107","author":"Lakatta","year":"2003","journal-title":"Circulation"},{"key":"2026073113114731300_vkag060-B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yjmcc.2015.04.005","article-title":"So! 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