{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:13:25Z","timestamp":1778123605555,"version":"3.51.4"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011019","name":"National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["K128525"],"award-info":[{"award-number":["K128525"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011019","name":"National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["155108"],"award-info":[{"award-number":["155108"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Debrecen Program for Scientific Publication"},{"name":"University of Debrecen Scientific Research Bridging Fund"},{"DOI":"10.13039\/501100011019","name":"National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["2024-1.2.3-HU-RIZONT-2024-00099"],"award-info":[{"award-number":["2024-1.2.3-HU-RIZONT-2024-00099"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EK\u00d6P-25-4 University Research Scholarship Program of the Ministry for Culture and Innovation"},{"name":"the National Research, Development and Innovation Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Genetically modified chimeric antigen receptor (CAR) T cells eliminate tumors by recognizing specific antigens on the cell surface. T cell ion channels (e.g. Kv1.3, KCa3.1) influence activation, proliferation, and effector functions such as target cell killing, through the regulation of Ca2+ signaling. We showed that CAR-expressing cells (Jurkat) specifically eliminate tumor cells (Raji B cells) in monolayer culture and inhibition of KCa3.1 by TRAM34 increased the tumor cell\u2013killing ability of KCa3.1+ Jurkat CARs. Blockage of KCa3.1 facilitated the migration of KCa3.1+ Jurkat CARs (mean speed, displacement and distance). The application of TRAM34 lowered the baseline Ca2+ level in mCherry-KCa3.1+ Jurkat CARs. Finally, TRAM34 significantly reduced the time needed to eliminate tumor cells. We concluded that expression and modification of KCa3.1 ion channels shifts the intracellular Ca2+ concentration into the range where cytotoxicity dominates. Hence, modification of KCa3.1 channels could contribute to a more effective anticancer immunotherapy.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag078","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T02:58:13Z","timestamp":1778122693000},"source":"Crossref","is-referenced-by-count":0,"title":["Role of Ca2+-activated KCa3.1 potassium channel in CAR T cell effector function"],"prefix":"10.1093","volume":"215","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9954-8277","authenticated-orcid":false,"given":"Vivien","family":"Jusztus","sequence":"first","affiliation":[{"name":"Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen , Debrecen,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rton","family":"Hajdu","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen , Debrecen,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen , Debrecen,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy\u00f6rgy","family":"Panyi","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen , Debrecen,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Hajdu","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen , Debrecen,","place":["Hungary"]},{"name":"Division of Dental Biochemistry, Department of Basic Medical Sciences, Faculty of Dentistry, University of Debrecen , Debrecen,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"2026050622580505700_vkag078-B1","doi-asserted-by":"crossref","first-page":"903562","DOI":"10.3389\/fimmu.2022.903562","article-title":"Utility and drawbacks of chimeric antigen receptor T cell (CAR-T) therapy in lung cancer","volume":"13","author":"Kandra","year":"2022","journal-title":"Front Immunol"},{"key":"2026050622580505700_vkag078-B2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41551-018-0235-9","article-title":"Programming CAR-T cells to kill cancer","volume":"2","author":"Labanieh","year":"2018","journal-title":"Nat Biomed Eng"},{"key":"2026050622580505700_vkag078-B3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41416-018-0325-1","article-title":"Teaching an old dog new tricks: next-generation CAR T cells","volume":"120","author":"Tokarew","year":"2019","journal-title":"Br J Cancer"},{"key":"2026050622580505700_vkag078-B4","doi-asserted-by":"crossref","first-page":"2114254","DOI":"10.1080\/21645515.2022.2114254","article-title":"Current updates on generations, approvals, and clinical trials of CAR T-cell therapy","volume":"18","author":"Asmamaw Dejenie","year":"2022","journal-title":"Hum Vaccin Immunother"},{"key":"2026050622580505700_vkag078-B5","doi-asserted-by":"crossref","first-page":"797440","DOI":"10.3389\/fbioe.2022.797440","article-title":"Chimeric antigen receptor T-cells: an overview of concepts, applications, limitations, and proposed solutions","volume":"10","author":"Alnefaie","year":"2022","journal-title":"Front Bioeng Biotechnol"},{"key":"2026050622580505700_vkag078-B6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41408-021-00459-7","article-title":"CAR-T cell therapy: current limitations and potential strategies","volume":"11","author":"Sterner","year":"2021","journal-title":"Blood Cancer J"},{"key":"2026050622580505700_vkag078-B7","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.3390\/cancers12061389","article-title":"Enhancing the efficacy of CAR T cells in the tumor microenvironment of pancreatic cancer","volume":"12","author":"Henze","year":"2020","journal-title":"Cancers"},{"key":"2026050622580505700_vkag078-B8","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1126\/science.aar6711","article-title":"CAR T cell immunotherapy for human cancer","volume":"359","author":"June","year":"2018","journal-title":"Science"},{"key":"2026050622580505700_vkag078-B9","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.ymthe.2020.10.022","article-title":"Clinical perspective: treatment of aggressive B cell lymphomas with FDA-approved CAR-T cell therapies","volume":"29","author":"Leick","year":"2021","journal-title":"Mol Ther"},{"key":"2026050622580505700_vkag078-B10","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-020-02128-1","article-title":"CAR T cells in solid tumors: challenges and opportunities","author":"Marofi","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"2026050622580505700_vkag078-B11","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1158\/2159-8290.CD-17-0263","article-title":"Inducible activation of MyD88 and CD40 in CAR T cells results in controllable and potent antitumor activity in preclinical solid tumor models","volume":"7","author":"Mata","year":"2017","journal-title":"Cancer Discov"},{"key":"2026050622580505700_vkag078-B12","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.15252\/emmm.201607485","article-title":"Clinical development of CAR T cells\u2014challenges and opportunities in translating innovative treatment concepts","volume":"9","author":"Hartmann","year":"2017","journal-title":"EMBO Mol Med"},{"key":"2026050622580505700_vkag078-B13","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1016\/j.ymthe.2020.09.015","article-title":"CAR T cell therapy for solid tumors: bright future or dark reality?","volume":"28","author":"Wagner","year":"2020","journal-title":"Mol Ther"},{"key":"2026050622580505700_vkag078-B14","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.omtm.2016.12.006","article-title":"Global manufacturing of CAR T cell therapy","volume":"4","author":"Levine","year":"2017","journal-title":"Mol Ther Methods Clin Dev"},{"key":"2026050622580505700_vkag078-B15","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41573-024-01100-5","article-title":"Novel strategies to manage CAR-T cell toxicity","volume":"24","author":"Mulvey","year":"2025","journal-title":"Nat Rev Drug Discov"},{"key":"2026050622580505700_vkag078-B16","first-page":"61","article-title":"Effectors of the future: universal chimeric antigen receptor","volume":"52","author":"Schlegel","year":"2025","journal-title":"Transfus Med Hemother"},{"key":"2026050622580505700_vkag078-B17","doi-asserted-by":"crossref","first-page":"1383894","DOI":"10.3389\/fimmu.2024.1383894","article-title":"Universal CAR 2.0 to overcome current limitations in CAR therapy","volume":"15","author":"Schlegel","year":"2024","journal-title":"Front Immunol"},{"key":"2026050622580505700_vkag078-B18","doi-asserted-by":"crossref","first-page":"e2405085121","DOI":"10.1073\/pnas.2405085121","article-title":"Dual ON\/OFF-switch chimeric antigen receptor controlled by 2 clinically approved drugs","volume":"121","author":"Giordano Attianese","year":"2024","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026050622580505700_vkag078-B19","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41467-024-55751-4","article-title":"Inhalable nanovesicles loaded with a STING agonist enhance CAR-T cell activity against solid tumors in the lung","volume":"16","author":"Zhu","year":"2025","journal-title":"Nat Commun"},{"key":"2026050622580505700_vkag078-B20","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.clim.2011.11.009","article-title":"The ion channel network in T lymphocytes, a target for immunotherapy","volume":"142","author":"Conforti","year":"2012","journal-title":"Clin Immunol"},{"key":"2026050622580505700_vkag078-B21","doi-asserted-by":"crossref","first-page":"6295","DOI":"10.1073\/pnas.90.13.6295","article-title":"Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores","volume":"90","author":"Zweifach","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026050622580505700_vkag078-B22","doi-asserted-by":"crossref","first-page":"e5193","DOI":"10.1073\/pnas.1718373115","article-title":"Mapping the functional anatomy of Orai1 transmembrane domains for CRAC channel gating","volume":"115","author":"Yeung","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026050622580505700_vkag078-B23","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ceca.2016.12.006","article-title":"Pore opening mechanism of CRAC channels","volume":"63","author":"Yeung","year":"2017","journal-title":"Cell Calcium"},{"key":"2026050622580505700_vkag078-B24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ceca.2019.02.009","article-title":"A novel STIM1-Orai1 gating interface essential for CRAC channel activation","volume":"79","author":"Butorac","year":"2019","journal-title":"Cell Calcium"},{"key":"2026050622580505700_vkag078-B25","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jmb.2014.09.021","article-title":"Structural and functional mechanisms of CRAC channel regulation","volume":"427","author":"Shim","year":"2015","journal-title":"J Mol Biol"},{"key":"2026050622580505700_vkag078-B26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ceca.2018.11.009","article-title":"STIM1 activation of Orai1","volume":"77","author":"Lunz","year":"2019","journal-title":"Cell Calcium"},{"key":"2026050622580505700_vkag078-B27","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-065X.2009.00816.x","article-title":"The functional network of ion channels in T lymphocytes","volume":"231","author":"Cahalan","year":"2009","journal-title":"Immunol Rev"},{"key":"2026050622580505700_vkag078-B28","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.4049\/jimmunol.156.4.1425","article-title":"T cell activation is regulated by voltage-dependent and calcium-activated potassium channels","volume":"156","author":"Rader","year":"1996","journal-title":"J Immunol"},{"key":"2026050622580505700_vkag078-B29","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1084\/jem.177.3.637","article-title":"Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation","volume":"177","author":"Lin","year":"1993","journal-title":"J Exp Med"},{"key":"2026050622580505700_vkag078-B30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.imlet.2009.05.004","article-title":"Functional consequences of Kv1.3 ion channel rearrangement into the immunological synapse","volume":"125","author":"T\u00f3th","year":"2009","journal-title":"Immunol Lett"},{"key":"2026050622580505700_vkag078-B31","doi-asserted-by":"crossref","first-page":"997621","DOI":"10.3389\/fimmu.2022.997621","article-title":"Regulatory role of KCa3.1 in immune cell function and its emerging association with rheumatoid arthritis","volume":"13","author":"Lin","year":"2022","journal-title":"Front Immunol"},{"key":"2026050622580505700_vkag078-B32","doi-asserted-by":"crossref","first-page":"20130106","DOI":"10.1098\/rstb.2013.0106","article-title":"Ion channels and anti-cancer immunity","volume":"369","author":"Panyi","year":"2014","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"2026050622580505700_vkag078-B33","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0143-4160(03)00045-9","article-title":"CRAC channels: activation, permeation, and the search for a molecular identity","volume":"33","author":"Prakriya","year":"2003","journal-title":"Cell Calcium"},{"key":"2026050622580505700_vkag078-B34","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1074\/jbc.M111.296798","article-title":"Functional blockade of the voltage-gated potassium channel Kv1.3 mediates reversion of T effector to central memory lymphocytes through SMAD3\/p21cip1 signaling","volume":"287","author":"Hu","year":"2012","journal-title":"J Biol Chem"},{"key":"2026050622580505700_vkag078-B35","doi-asserted-by":"crossref","first-page":"e54267","DOI":"10.1371\/journal.pone.0054267","article-title":"Blockade of Kv1.3 potassium channels inhibits differentiation and Granzyme B secretion of human CD8+ T effector memory lymphocytes","volume":"8","author":"Hu","year":"2013","journal-title":"PLoS ONE"},{"key":"2026050622580505700_vkag078-B36","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev-immunol-032414-112212","article-title":"Ion channels in innate and adaptive immunity","volume":"33","author":"Feske","year":"2015","journal-title":"Annu Rev Immunol"},{"key":"2026050622580505700_vkag078-B37","doi-asserted-by":"crossref","first-page":"eaaq1616","DOI":"10.1126\/scisignal.aaq1616","article-title":"A defect in KCa3.1 channel activity limits the ability of CD8(+) T cells from cancer patients to infiltrate an adenosine-rich microenvironment","volume":"11","author":"Chimote","year":"2018","journal-title":"Sci Signal"},{"key":"2026050622580505700_vkag078-B38","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.3390\/cells12162065","article-title":"Reduction of Ca2+ entry by a specific block of KCa3.1 channels optimizes cytotoxic activity of NK cells against T-ALL Jurkat cells","volume":"12","author":"Olivas-Aguirre","year":"2023","journal-title":"Cells"},{"key":"2026050622580505700_vkag078-B39","doi-asserted-by":"crossref","first-page":"e76740","DOI":"10.1371\/journal.pone.0076740","article-title":"Blocking KCa3.1 channels increases tumor cell killing by a subpopulation of human natural killer lymphocytes","volume":"8","author":"Koshy","year":"2013","journal-title":"PLoS One"},{"key":"2026050622580505700_vkag078-B40","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1113\/JP274964","article-title":"A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity","volume":"596","author":"Zhou","year":"2018","journal-title":"J Physiol"},{"key":"2026050622580505700_vkag078-B41","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1093\/jimmun\/vkaf084","article-title":"Role of CAR-T cell K+ channels in tumor infiltration and elimination","volume":"214","author":"Jusztus","year":"2025","journal-title":"J Immunol"},{"key":"2026050622580505700_vkag078-B42","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1006\/smim.1998.0142","article-title":"Introduction: the role of innate immunity in the adaptive immune response","volume":"10","author":"Janeway","year":"1998","journal-title":"Semin Immunol"},{"key":"2026050622580505700_vkag078-B43","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1034\/j.1600-065X.2000.917309.x","article-title":"Innate immune recognition: mechanisms and pathways","volume":"173","author":"Medzhitov","year":"2000","journal-title":"Immunol Rev"},{"key":"2026050622580505700_vkag078-B44","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1006\/smim.1998.0136","article-title":"Innate immune recognition and control of adaptive immune responses","volume":"10","author":"Medzhitov","year":"1998","journal-title":"Semin Immunol"},{"key":"2026050622580505700_vkag078-B45","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.semcdb.2020.12.002","article-title":"A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity","volume":"115","author":"Kaschek","year":"2021","journal-title":"Semin Cell Dev Biol"},{"key":"2026050622580505700_vkag078-B46","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/bs.mcb.2022.09.012","article-title":"T cell activation and effector function in the human Jurkat T cell model","volume":"178","author":"Carrasco-Padilla","year":"2023","journal-title":"Methods Cell Biol"},{"key":"2026050622580505700_vkag078-B47","doi-asserted-by":"crossref","first-page":"6296","DOI":"10.4049\/jimmunol.0900613","article-title":"Localization of Kv1.3 channels in the immunological synapse modulates the calcium response to antigen stimulation in T lymphocytes","volume":"183","author":"Nicolaou","year":"2009","journal-title":"J Immunol"},{"key":"2026050622580505700_vkag078-B48","doi-asserted-by":"crossref","first-page":"685092","DOI":"10.3389\/fphar.2021.685092","article-title":"Loureirin B exerts its immunosuppressive effects by inhibiting STIM1\/Orai1 and K(V)1.3 channels","volume":"12","author":"Shi","year":"2021","journal-title":"Front Pharmacol"},{"key":"2026050622580505700_vkag078-B49","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.omtm.2020.01.012","article-title":"A high-throughput method for characterizing novel chimeric antigen receptors in Jurkat cells","volume":"16","author":"Bloemberg","year":"2020","journal-title":"Mol Ther Methods Clin Dev"},{"key":"2026050622580505700_vkag078-B50","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1093\/jimmun\/vkaf199","article-title":"Functional role of Kv1.3 localization in chimeric antigen receptor T cells","volume":"214","author":"Medyouni","year":"2025","journal-title":"J Immunol"},{"key":"2026050622580505700_vkag078-B51","doi-asserted-by":"crossref","first-page":"9163","DOI":"10.3390\/ijms21239163","article-title":"Identification of potent CD19 scFv for CAR T cells through scFv screening with NK\/T-cell line","volume":"21","author":"Kang","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2026050622580505700_vkag078-B52","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jaut.2016.03.004","article-title":"Nanovesicle-targeted Kv1.3 knockdown in memory T cells suppresses CD40L expression and memory phenotype","volume":"69","author":"Chimote","year":"2016","journal-title":"J Autoimmun"},{"key":"2026050622580505700_vkag078-B53","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.3390\/ijms25041949","article-title":"Activity of potassium channels in CD8+ T lymphocytes: diagnostic and prognostic biomarker in ovarian cancer?","volume":"25","author":"Jusztus","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026050622580505700_vkag078-B54","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1084\/jem.160.2.369","article-title":"Voltage-gated potassium channels are required for human T lymphocyte activation","volume":"160","author":"Chandy","year":"1984","journal-title":"J Exp Med"},{"key":"2026050622580505700_vkag078-B55","doi-asserted-by":"crossref","first-page":"12249","DOI":"10.1074\/jbc.M011342200","article-title":"Calcium-activated potassium channels sustain calcium signaling in T lymphocytes. Selective blockers and manipulated channel expression levels","volume":"276","author":"Fanger","year":"2001","journal-title":"J Biol Chem"},{"key":"2026050622580505700_vkag078-B56","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12964-015-0112-z","article-title":"Orai\/CRACM1 and KCa3.1 ion channels interact in the human lung mast cell plasma membrane","volume":"13","author":"Duffy","year":"2015","journal-title":"Cell Commun Signal"},{"key":"2026050622580505700_vkag078-B57","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1016\/S0022-2275(20)41096-X","article-title":"Regulation of calcium influx and catecholamine secretion in chromaffin cells by a cytochrome P450 metabolite of arachidonic acid","volume":"36","author":"Hildebrandt","year":"1995","journal-title":"J Lipid Res"},{"key":"2026050622580505700_vkag078-B58","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/sj.bjp.0703631","article-title":"Pharmacological evaluation of the role of cytochrome P450 in intracellular calcium signalling in rat pancreatic acinar cells","volume":"131","author":"Bruce","year":"2000","journal-title":"Br J Pharmacol"},{"key":"2026050622580505700_vkag078-B59","doi-asserted-by":"crossref","first-page":"e63028","DOI":"10.1371\/journal.pone.0063028","article-title":"TRAM-34, a putatively selective blocker of intermediate-conductance, calcium-activated potassium channels, inhibits cytochrome P450 activity","volume":"8","author":"Agarwal","year":"2013","journal-title":"PLoS One"},{"key":"2026050622580505700_vkag078-B60","doi-asserted-by":"crossref","first-page":"36360","DOI":"10.1038\/s41598-025-20101-x","article-title":"KCa3.1 channels regulate the tumor infiltration of functionally competent NK cells in head and neck cancer","volume":"15","author":"Alshwimi","year":"2025","journal-title":"Sci Rep"},{"key":"2026050622580505700_vkag078-B61","doi-asserted-by":"crossref","first-page":"e104730","DOI":"10.15252\/embj.2020104730","article-title":"Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR)","volume":"39","author":"Dong","year":"2020","journal-title":"Embo J"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/215\/4\/vkag078\/68236772\/vkag078.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/215\/4\/vkag078\/68236772\/vkag078.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T02:58:19Z","timestamp":1778122699000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/doi\/10.1093\/jimmun\/vkag078\/8671572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4,15]]}},"URL":"https:\/\/doi.org\/10.1093\/jimmun\/vkag078","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2026,4]]},"article-number":"vkag078"}}