{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:09:20Z","timestamp":1788786560568,"version":"build-2803163510"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Institute of Allergy and Infectious Diseases of the National Institutes of Health","award":["AI145816"],"award-info":[{"award-number":["AI145816"]}]},{"name":"National Institute of Allergy and Infectious Diseases of the National Institutes of Health","award":["AI064227"],"award-info":[{"award-number":["AI064227"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Modulation of T cell receptor (TCR) sensitivity during positive selection is critical to avoid negative selection and direct thymocytes into their appropriate lineage. Thymocytes just prior to positive selection (preselection) are highly responsive to low affinity self-ligands and are also actively rearranging their TCR\u03b1 locus as they await a positive selection signal. Preselection double-positive thymocytes were thought to be relatively homogeneous, and TCR modulation during this stage had not been previously described. Here, we provide evidence for progressive gene expression changes within the preselection double-positive thymocyte population that correlates with a gradual reduction in TCR responsiveness and reduced upregulation of TCR target genes associated with the CD4 fate. We relate these observations to the link between positive selection and T cell lineage commitment.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag105","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:41:33Z","timestamp":1781311293000},"source":"Crossref","is-referenced-by-count":1,"title":["Preselection CD4+CD8+ thymocytes modulate TCR responsiveness following TCR\u03b2 selection"],"prefix":"10.1093","volume":"215","author":[{"given":"Esther Jeong Yoon","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley , Berkeley, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik A","family":"Aylard","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley , Berkeley, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zo\u00eb","family":"Steier","sequence":"additional","affiliation":[{"name":"Institute for Medical Engineering and Science, Massachusetts Institute of Technology , Cambridge, MA,","place":["United States"]},{"name":"Broad Institute of MIT and Harvard Institute for Medical Engineering and Science, , Cambridge, MA,","place":["United States"]},{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard , Cambridge, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley , Berkeley, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley , Berkeley, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley , Berkeley, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Streets","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of California, Berkeley , Berkeley, CA,","place":["United States"]},{"name":"Center for Computational Biology, University of California, Berkeley , Berkeley, CA,","place":["United States"]},{"name":"Chan Zuckerberg Biohub \u2013 San Francisco , San Francisco, CA,","place":["United 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