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In the current study, we assessed the function and pathogenicity of 1C6 CD8+ T cells. We found that they proliferated and produced inflammatory cytokines in response to MOG[35\u201355] peptide under both T cytotoxic 1 (Tc1) and Tc17 differentiation conditions, albeit with reduced expansion relative to their Th1 or Th17 counterparts. Both 1C6 Tc1 and Tc17 cells were able to induce experimental autoimmune encephalomyelitis upon adoptive transfer to NOD.Scid mice. Intriguingly, we noted in vivo expansion of CD4+ T cells in the spleen and CNS of NOD.Scid recipients as well as in lymphocyte-sufficient animals, despite 1C6 Tc cells being purified on CD8 expression prior to transfer. Furthermore, 1C6 Tc17 cells expressed ThPOK, a master differentiation factor for CD4+ T cells. Finally, anti-CD4+ T cell blockade abrogated CD8+ T cell infiltration of the CNS and disease induction in Tc17 recipient mice. Our data provide insight into the interplay of CD4+ and CD8+ T cells in CNS autoimmunity.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag107","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T10:38:42Z","timestamp":1779705522000},"source":"Crossref","is-referenced-by-count":2,"title":["Myelin antigen\u2013specific effector CD8+ T cells induce chronic CNS autoimmunity in a CD4+ T cell\u2013dependent manner"],"prefix":"10.1093","volume":"215","author":[{"given":"Irshad","family":"Akbar","sequence":"first","affiliation":[{"name":"axe Neurosciences, Centre de recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval , Qu\u00e9bec, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prenitha Mercy Ignatius","family":"Arokia Doss","sequence":"additional","affiliation":[{"name":"axe Neurosciences, Centre de recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval , Qu\u00e9bec, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preya U","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Toronto , Toronto, ON,","place":["Canada"]},{"name":"Krembil Research Institute, University Health Network , Toronto, ON,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batul","family":"Surury","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Toronto , Toronto, ON,","place":["Canada"]},{"name":"Krembil Research Institute, University Health Network , Toronto, ON,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanie","family":"Baillargeon","sequence":"additional","affiliation":[{"name":"axe Neurosciences, Centre de recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval , Qu\u00e9bec, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Reda","family":"Fazazi","sequence":"additional","affiliation":[{"name":"axe Neurosciences, Centre de recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval , Qu\u00e9bec, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C","family":"Anderson","sequence":"additional","affiliation":[{"name":"Gene Lay Institute for Immunology and Inflammation and Ann Romney Center for Neurologic Diseases, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga L","family":"Rojas","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Toronto , Toronto, ON,","place":["Canada"]},{"name":"Krembil Research Institute, University Health Network , Toronto, ON,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Lassmann","sequence":"additional","affiliation":[{"name":"Division of 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