{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:09:33Z","timestamp":1788786573267,"version":"build-2803163510"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"IDMIT"},{"DOI":"10.13039\/100020806","name":"ANR","doi-asserted-by":"publisher","award":["ANR-11-INBS-0008"],"award-info":[{"award-number":["ANR-11-INBS-0008"]}],"id":[{"id":"10.13039\/100020806","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovative Medicines Initiative 2 Joint Undertaking","award":["853989"],"award-info":[{"award-number":["853989"]}]},{"name":"European Accelerator of Tuberculosis Regime Project"},{"name":"European Union\u2019s Horizon 2020 Research and Innovation Programme"},{"name":"EFPIA and Global Alliance for TB Drug Development Non-Profit Organization"},{"DOI":"10.13039\/100000865","name":"Bill & Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008890","name":"University of Dundee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008890","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the European Union"},{"DOI":"10.13039\/100013322","name":"EFPIA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale\u201d","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is associated with clinical diversity and outcomes ranging from latent TB to active TB with distinct pathophysiologies. However, our understanding of the innate immune mechanisms related to the protection or progression of TB is limited. Among innate immune cells, the role of neutrophils is not fully elucidated, as they have been shown to exhibit both protective and harmful capacities in TB. We hypothesized that Mtb infection induces changes in neutrophil phenotype and function, influencing the infection outcomes. Based on clinical, bacteriological, and positron emission tomography with x-ray computed tomography (PET\/CT) scan parameters, cynomolgus macaques infected by Mtb were stratified into two categories: animals that rapidly progressed to an active form of TB, designated as \u201cfast progressors,\u201d and \u201cslow progressors,\u201d which include low symptomatic or asymptomatic animals. In this study, we identified transcriptomic signatures of type I interferons and neutrophil degranulation in macaques with fast progression to active TB, which were not observed in animals with slow TB progression. Unsupervised mass cytometry analysis showed the emergence of blood immature neutrophils (CD101+ CD10\u2212) in fast-progressing animals. In addition, bulk blood neutrophils from infected animals displayed capacities to modulate TNF-\u03b1 production and cytotoxic function of CD8 T cells in a contact-dependent mechanism. In lung granulomas, neutrophils showed a tissue-specific phenotype (CD101\u2212 CD10+), with greater infiltration in animals with active TB. These data suggest that neutrophil subpopulations are associated with disease progression, with capacities to modulate CD8 T cells\u2019 functions, which in turn may contribute to disease progression.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag114","type":"journal-article","created":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T17:38:47Z","timestamp":1782063527000},"source":"Crossref","is-referenced-by-count":0,"title":["Disease progression is associated with differential neutrophil maturation in\n                    <i>Mycobacterium tuberculosis<\/i>\n                    \u2013infected macaques"],"prefix":"10.1093","volume":"215","author":[{"given":"Stanley","family":"Dinko","sequence":"first","affiliation":[{"name":"Immune Diseases, Microbiology and Innovative Therapies (IDMIT\/UMRS1184), Universit\u00e9 Paris-Saclay \u2013 Inserm - CEA, Fontenay-aux-Roses & Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candie","family":"Joly","sequence":"additional","affiliation":[{"name":"Immune Diseases, Microbiology and Innovative Therapies (IDMIT\/UMRS1184), Universit\u00e9 Paris-Saclay \u2013 Inserm - CEA, Fontenay-aux-Roses & Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Mazet","sequence":"additional","affiliation":[{"name":"Immune Diseases, Microbiology and Innovative Therapies (IDMIT\/UMRS1184), Universit\u00e9 Paris-Saclay \u2013 Inserm - CEA, Fontenay-aux-Roses & Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Sandillon","sequence":"additional","affiliation":[{"name":"Immune Diseases, Microbiology and Innovative Therapies (IDMIT\/UMRS1184), Universit\u00e9 Paris-Saclay \u2013 Inserm - CEA, Fontenay-aux-Roses & Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Magneron","sequence":"additional","affiliation":[{"name":"Immune Diseases, Microbiology and Innovative Therapies (IDMIT\/UMRS1184), Universit\u00e9 Paris-Saclay \u2013 Inserm - CEA, Fontenay-aux-Roses & Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Nunez","sequence":"additional","affiliation":[{"name":"Life and Soft, A SeqOne Company, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Mayet","sequence":"additional","affiliation":[{"name":"Life and Soft, A SeqOne Company, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9gol\u00e8ne","family":"Diry","sequence":"additional","affiliation":[{"name":"Life and Soft, A SeqOne Company, Montpellier, 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