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Allergens stimulate Ca2+-dependent pro-inflammatory cytokine and chemokine gene expression through the opening of ORAI1 Ca2+ channels in the surface membrane of various immune cell-types within the lung. ORAI1 participates in a signalosome with the scaffolding protein A-kinase anchoring protein (AKAP)79\/150 (encoded by the Akap5 gene), which binds numerous protein kinases, calcineurin and transcription factors required for cytokine expression. However, the role of AKAP79\/150 in immune cell activation and the development of airway inflammation in response to allergens has not been established. We found that AKAP79\/150 is expressed in mast cells and macrophages, where it has a pivotal role in driving pro-inflammatory cytokine production in response to house dust mite challenge. By contrast, AKAP79\/150 expression in T cells was low and had little impact on cytokine release following T cell activation. Akap5\u2212\/\u2212 mice exhibited significantly reduced type 2 inflammation in the lungs following HDM exposure compared with wild-type controls. Our data demonstrate that AKAP79\/150 is an important co-ordinator of inflammation within the lung in response to airborne allergens, through actions primarily on cells of the innate immune system.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag115","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T16:46:23Z","timestamp":1783356383000},"source":"Crossref","is-referenced-by-count":0,"title":["The scaffolding protein AKAP79\/150 shapes innate immune responses to allergen"],"prefix":"10.1093","volume":"215","author":[{"given":"Suneet","family":"Kaur","sequence":"first","affiliation":[{"name":"Molecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health , Durham, NC,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ping","family":"Lin","sequence":"additional","affiliation":[{"name":"Molecular and Cellular Biology Laboratory, National Institute of 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