{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:10:45Z","timestamp":1788793845730,"version":"build-2803163510"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"SNSF","doi-asserted-by":"publisher","award":["310030_219210"],"award-info":[{"award-number":["310030_219210"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Regulators of G protein signaling (RGS) deactivate G proteins associated with G protein-coupled receptors (GPCRs), a large receptor family with diverse functions. Of the 20 RGS, the Rgs14 single-nucleotide polymorphism is associated with inflammatory bowel disease, and Rgs14 expression is higher in macrophages than in epithelial cells. This manuscript describes a novel conditional mouse line that enables deletion of Rgs14 in macrophages and intestinal epithelial cells. We demonstrate that Rgs14 deletion in macrophages increases their reactive oxygen species production and their ability to induce T cell proliferation. The deletion in macrophages, but not in epithelial cells, exacerbates colitis severity. This novel conditional mouse model will facilitate further investigation of Rgs14 in inflammatory bowel disease and potentially in other areas, including metabolism, neuroscience, and aging.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag135","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:02:05Z","timestamp":1782450125000},"source":"Crossref","is-referenced-by-count":0,"title":["Genetic deletion of the inflammatory bowel disease-associated risk gene Rgs14 aggravates experimental colitis"],"prefix":"10.1093","volume":"215","author":[{"given":"Mao","family":"Chen","sequence":"first","affiliation":[{"name":"University of Basel Gastroenterology, Department of Biomedicine, , Hebelstrasse 20 , Basel 4031,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Melhem","sequence":"additional","affiliation":[{"name":"University of Basel Gastroenterology, Department of Biomedicine, , Hebelstrasse 20 , Basel 4031,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Hendrik","family":"Niess","sequence":"additional","affiliation":[{"name":"University of Basel Gastroenterology, Department of Biomedicine, , Hebelstrasse 20 , Basel 4031,","place":["Switzerland"]},{"name":"University Digestive Health Care Center Clarunis Department of Gastroenterology and Hepatology, , Basel 4002,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"2026090710445737300_vkag135-B1","doi-asserted-by":"crossref","first-page":"100671","DOI":"10.1016\/j.bbih.2023.100671","article-title":"G protein-coupled receptors: a target for microbial metabolites and a mechanistic link to microbiome-immune-brain interactions","volume":"32","author":"Aleti","year":"2023","journal-title":"Brain Behav Immun Health"},{"key":"2026090710445737300_vkag135-B2","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.arcmed.2020.11.011","article-title":"Genetic polymorphisms of rgs14 and renal stone disease","volume":"52","author":"Guan","year":"2021","journal-title":"Arch Med Res"},{"key":"2026090710445737300_vkag135-B3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s12031-025-02413-9","article-title":"Rgs2-related non-coding interaction network modulates the nf-kappa b signaling pathway in ms patients: A systems biology investigation","volume":"75","author":"Forouzanfar","year":"2025","journal-title":"J Mol Neurosci"},{"key":"2026090710445737300_vkag135-B4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00213-012-2888-5","article-title":"Brain rgs4 and rgs10 protein expression in schizophrenia and depression. 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