{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:10:46Z","timestamp":1788793846610,"version":"build-2803163510"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute lung injury (ALI) is a fulminant respiratory failure syndrome with no targeted therapy. We show that Inhba is sharply upregulated in the damaged lung tissue of mice and in BEAS-2B cells, and its abundance tracks with cytokine storm and reactive oxygen species (ROS). Mechanistically, AKT activation is associated with increased FOXA1 phosphorylation and abundance, which transcriptionally induce INHBA; this upregulation of\u00a0INHBA is a key upstream driver of enhanced ROS production and cytokine release in experimental ALI. Genetic deletion or pharmacologic blockade of PI3K\/AKT simultaneously lowered Foxa1 and Inhba, reduced TNF-\u03b1, IL-6, and ROS, and improved histologic injury scores and oxygenation. These findings establish the PI3K\/AKT\u2013Foxa1\u2013Inhba axis as a central driver in experimental ALI models and support its potential as a druggable target for future investigation. Further validation in human ALI samples will be required to support clinical translation.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag140","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:26:38Z","timestamp":1783556798000},"source":"Crossref","is-referenced-by-count":0,"title":["Inhba is transcriptionally regulated by Foxa1 through the PI3K\/AKT signal pathway in acute lung injury"],"prefix":"10.1093","volume":"215","author":[{"given":"Yuanhua","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, The First Affiliated Hospital of Zhengzhou University , Zhengzhou, Henan,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University , Zhengzhou, Henan,","place":["PR 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