{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:10:43Z","timestamp":1788793843885,"version":"build-2803163510"},"reference-count":126,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1DP2CA247830-01"],"award-info":[{"award-number":["1DP2CA247830-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35GM156411"],"award-info":[{"award-number":["R35GM156411"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"IVRI-Aduro Biotech"},{"DOI":"10.13039\/100015596","name":"Siebel Stem Cell Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015596","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["RSG-22-026-01"],"award-info":[{"award-number":["RSG-22-026-01"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"name":"RNA Bioscience Initiative"},{"DOI":"10.13039\/100014807","name":"Cancer Research Coordinating committee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pew-Stewart Scholar and a St. Baldrick\u2019s Scholar"},{"name":"Hope with Hazel"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Regulatory T cells (Tregs) are critical guardians of immune homeostasis that must operate in diverse and often inflammatory conditions. However, the mechanisms that Tregs use to maintain their stability and function, especially in response to the stresses of distinct microenvironments, remain incompletely understood. Previous work identified the repressive chromatin modification histone 3 lysine 27 trimethylation (H3K27me3) as a rheostat for Treg function. Here, we find that loss of H3K27me3 in Tregs activates the tumor suppressor p53. Stabilization of p53 using the MDM2 inhibitor Nutlin-3 protected Tregs from losing their master transcription factor FOXP3 in vitro when cultured with the T helper 17 cytokines interleukin-6 and interleukin-1\u03b2, while p53 deficiency rendered Tregs more prone to FOXP3 loss. Treg-specific p53 deficiency resulted in the accumulation of cells that had lost Foxp3 expression (\u201cex-Tregs\u201d) and a reduction of suppressive markers on Tregs specifically in the colon. Additionally, these mice exhibited inflammation in the colon at homeostasis and increased severity of induced colitis. These results demonstrate a specific role for p53 in the maintenance of Treg stability in inflammatory T helper 17\u2013polarizing environments and present a possible target for improving Treg-based immunotherapies for diseases defined by intestinal inflammation, such as inflammatory bowel disease.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag145","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:53:46Z","timestamp":1783457626000},"source":"Crossref","is-referenced-by-count":0,"title":["Epigenetic control of p53 activity in regulatory T cells maintains their identity to prevent inflammation"],"prefix":"10.1093","volume":"215","author":[{"given":"Stephanie","family":"Silveria","sequence":"first","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley , Berkeley, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneke G C","family":"Peeters","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley , Berkeley, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Vickery","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley , Berkeley, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovana M B","family":"Veronezi","sequence":"additional","affiliation":[{"name":"Molecular Biology Graduate Program, University of Colorado Anschutz Medical Campus , Aurora, CO,","place":["United States"]},{"name":"Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus , Aurora, CO,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2929-1377","authenticated-orcid":false,"given":"Srinivas","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus , Aurora, CO,","place":["United States"]},{"name":"RNA Bioscience Initiative, University of Colorado School of Medicine , Aurora, CO,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1479-9840","authenticated-orcid":false,"given":"Michel","family":"DuPage","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley , Berkeley, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"2026090710434107500_vkag145-B1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.cell.2008.05.009","article-title":"Regulatory T cells and immune tolerance","volume":"133","author":"Sakaguchi","year":"2008","journal-title":"Cell"},{"key":"2026090710434107500_vkag145-B2","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.cell.2015.08.021","article-title":"A distinct function of regulatory T cells in tissue protection","volume":"162","author":"Arpaia","year":"2015","journal-title":"Cell"},{"key":"2026090710434107500_vkag145-B3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/ni1428","article-title":"Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice","volume":"8","author":"Kim","year":"2007","journal-title":"Nat Immunol"},{"key":"2026090710434107500_vkag145-B4","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3389\/fimmu.2013.00106","article-title":"Molecular determinants of regulatory T cell development: the essential roles of epigenetic changes","volume":"4","author":"Kitagawa","year":"2013","journal-title":"Front Immunol"},{"key":"2026090710434107500_vkag145-B5","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ni904","article-title":"Foxp3 programs the development and function of CD4+CD25+ regulatory T cells","volume":"4","author":"Fontenot","year":"2003","journal-title":"Nat Immunol"},{"key":"2026090710434107500_vkag145-B6","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"2026090710434107500_vkag145-B7","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/nature08750","article-title":"Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate","volume":"463","author":"Zheng","year":"2010","journal-title":"Nature"},{"key":"2026090710434107500_vkag145-B8","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.immuni.2015.07.017","article-title":"Hydrogen sulfide promotes Tet1- and Tet2-mediated Foxp3 demethylation to drive regulatory T cell differentiation and maintain immune homeostasis","volume":"43","author":"Yang","year":"2015","journal-title":"Immunity"},{"key":"2026090710434107500_vkag145-B9","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1182\/blood-2012-08-451765","article-title":"Foxp3+ T-regulatory cells require DNA methyltransferase 1 expression to prevent development of lethal autoimmunity","volume":"121","author":"Wang","year":"2013","journal-title":"Blood"},{"key":"2026090710434107500_vkag145-B10","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.4049\/jimmunol.1203473","article-title":"Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus","volume":"190","author":"Toker","year":"2013","journal-title":"J Immunol"},{"key":"2026090710434107500_vkag145-B11","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/ni.2886","article-title":"The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells","volume":"15","author":"Obata","year":"2014","journal-title":"Nat Immunol"},{"key":"2026090710434107500_vkag145-B12","doi-asserted-by":"crossref","first-page":"259","DOI":"10.4049\/jimmunol.182.1.259","article-title":"Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation","volume":"182","author":"Lal","year":"2009","journal-title":"J Immunol"},{"key":"2026090710434107500_vkag145-B13","doi-asserted-by":"crossref","first-page":"6648","DOI":"10.4049\/jimmunol.0803320","article-title":"Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1","volume":"182","author":"Josefowicz","year":"2009","journal-title":"J Immunol"},{"key":"2026090710434107500_vkag145-B14","doi-asserted-by":"crossref","first-page":"6571","DOI":"10.1172\/JCI137712","article-title":"Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function","volume":"130","author":"Helmin","year":"2020","journal-title":"J Clin Invest"},{"key":"2026090710434107500_vkag145-B15","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1371\/journal.pbio.0050038","article-title":"Epigenetic control of the foxp3 locus in regulatory T cells","volume":"5","author":"Floess","year":"2007","journal-title":"PLoS Biol"},{"key":"2026090710434107500_vkag145-B16","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ni.2868","article-title":"Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells","volume":"15","author":"Arvey","year":"2014","journal-title":"Nat Immunol"},{"key":"2026090710434107500_vkag145-B17","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1172\/JCI131375","article-title":"Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity","volume":"130","author":"Xiong","year":"2020","journal-title":"J Clin Invest"},{"key":"2026090710434107500_vkag145-B18","doi-asserted-by":"crossref","first-page":"3993","DOI":"10.1128\/MCB.00919-14","article-title":"Two histone\/protein acetyltransferases, CBP and p300, are indispensable for Foxp3+ T-regulatory cell development and function","volume":"34","author":"Liu","year":"2014","journal-title":"Mol Cell Biol"},{"key":"2026090710434107500_vkag145-B19","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.immuni.2015.01.007","article-title":"The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation","volume":"42","author":"DuPage","year":"2015","journal-title":"Immunity"},{"key":"2026090710434107500_vkag145-B20","doi-asserted-by":"crossref","first-page":"10643","DOI":"10.1038\/srep10643","article-title":"EZH2 is crucial for both differentiation of regulatory T cells and T effector cell expansion","volume":"5","author":"Yang","year":"2015","journal-title":"Sci Rep"},{"key":"2026090710434107500_vkag145-B21","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1074\/jbc.M116.749663","article-title":"The role of the histone methyltransferase enhancer of zeste homolog 2 (EZH2) in the pathobiological mechanisms underlying inflammatory bowel disease (IBD)","volume":"292","author":"Sarmento","year":"2017","journal-title":"J Biol Chem"},{"key":"2026090710434107500_vkag145-B22","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1182\/blood-2013-12-544106","article-title":"The polycomb repressive complex 2 governs life and death of peripheral T cells","volume":"124","author":"Zhang","year":"2014","journal-title":"Blood"},{"key":"2026090710434107500_vkag145-B23","doi-asserted-by":"crossref","first-page":"114724","DOI":"10.1016\/j.celrep.2024.114724","article-title":"Hyperactivating EZH2 to augment H3K27me3 levels in regulatory T cells enhances immune suppression by driving early effector differentiation","volume":"43","author":"Peeters","year":"2024","journal-title":"Cell Rep"},{"key":"2026090710434107500_vkag145-B24","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1016\/j.celrep.2018.05.050","article-title":"Targeting EZH2 reprograms intratumoral regulatory T cells to enhance cancer immunity","volume":"23","author":"Wang","year":"2018","journal-title":"Cell Rep"},{"key":"2026090710434107500_vkag145-B25","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.tcb.2020.12.011","article-title":"P53 and tumor suppression: it takes a network","volume":"31","author":"Boutelle","year":"2021","journal-title":"Trends Cell Biol"},{"key":"2026090710434107500_vkag145-B26","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.molmet.2019.10.002","article-title":"Metabolic functions of the tumor suppressor p53: implications in normal physiology, metabolic disorders, and cancer","volume":"33","author":"Lacroix","year":"2020","journal-title":"Mol Metab"},{"key":"2026090710434107500_vkag145-B27","doi-asserted-by":"crossref","first-page":"188556","DOI":"10.1016\/j.bbcan.2021.188556","article-title":"Tumor suppressor p53: biology, signaling pathways, and therapeutic targeting","volume":"1876","author":"Hern\u00e1ndez Borrero","year":"2021","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"2026090710434107500_vkag145-B28","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.freeradbiomed.2018.05.074","article-title":"The tumor suppressor protein p53 and the ferroptosis network","volume":"133","author":"Kang","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"2026090710434107500_vkag145-B29","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/s41419-023-05567-9","article-title":"Regulation of immunological tolerance by the p53-inhibitor iASPP","volume":"14","author":"Akama-Garren","year":"2023","journal-title":"Cell Death Dis"},{"key":"2026090710434107500_vkag145-B30","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nri.2016.99","article-title":"Emerging roles of p53 and other tumour-suppressor genes in immune regulation","volume":"16","author":"Mu\u00f1oz-Fontela","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"2026090710434107500_vkag145-B31","doi-asserted-by":"crossref","first-page":"217614","DOI":"10.1016\/j.canlet.2025.217614","article-title":"Targeting p53 for immune modulation: Exploring its functions in tumor immunity and inflammation","volume":"617","author":"Wu","year":"2025","journal-title":"Cancer Lett"},{"key":"2026090710434107500_vkag145-B32","doi-asserted-by":"crossref","first-page":"111167","DOI":"10.1016\/j.intimp.2023.111167","article-title":"Boosting regulatory T cell-dependent immune tolerance by activation of p53","volume":"125","author":"Cui","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"2026090710434107500_vkag145-B33","doi-asserted-by":"publisher","first-page":"7645","DOI":"10.3390\/ijms24087645","article-title":"The wheel of p53 helps to drive the immune system","volume":"24","author":"\u0141asut-Szyszka","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026090710434107500_vkag145-B34","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1182\/blood-2016-12-758961","article-title":"Thymic epithelial cells require p53 to support their long-term function in thymopoiesis in mice","volume":"130","author":"Rodrigues","year":"2017","journal-title":"Blood"},{"key":"2026090710434107500_vkag145-B35","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1172\/JCI0214967","article-title":"p53 negatively regulates intestinal immunity by delaying mucosal T cell cycling","volume":"109","author":"Sturm","year":"2002","journal-title":"J Clin Invest"},{"key":"2026090710434107500_vkag145-B36","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/s41586-025-09424-x","article-title":"Thymic epithelial cells amplify epigenetic noise to promote immune tolerance","volume":"646","author":"Gamble","year":"2025","journal-title":"Nature"},{"key":"2026090710434107500_vkag145-B37","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1002\/art.21099","article-title":"Regulation of arthritis by p53: critical role of adaptive immunity","volume":"52","author":"Simelyte","year":"2005","journal-title":"Arthritis Rheum"},{"key":"2026090710434107500_vkag145-B38","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1365-2249.2008.03629.x","article-title":"The tumour suppressor gene p53 modulates the severity of antigen-induced arthritis and the systemic immune response","volume":"152","author":"Leech","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"2026090710434107500_vkag145-B39","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0165-5728(02)00428-9","article-title":"Regulatory role of p53 in experimental autoimmune encephalomyelitis","volume":"135","author":"Okuda","year":"2003","journal-title":"J Neuroimmunol"},{"key":"2026090710434107500_vkag145-B40","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.2337\/diabetes.54.5.1423","article-title":"Tumor suppressor p53 inhibits autoimmune inflammation and macrophage function","volume":"54","author":"Zheng","year":"2005","journal-title":"Diabetes"},{"key":"2026090710434107500_vkag145-B41","doi-asserted-by":"crossref","first-page":"3614","DOI":"10.4049\/jimmunol.1300509","article-title":"Tumor suppressor p53 inhibits systemic autoimmune diseases by inducing regulatory T cells","volume":"191","author":"Kawashima","year":"2013","journal-title":"J Immunol"},{"key":"2026090710434107500_vkag145-B42","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/art.37841","article-title":"p53 controls autoimmune arthritis via STAT-mediated regulation of the Th17 cell\/Treg cell balance in mice","volume":"65","author":"Park","year":"2013","journal-title":"Arthritis Rheum"},{"key":"2026090710434107500_vkag145-B43","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1053\/j.gastro.2010.12.002","article-title":"Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases","volume":"140","author":"Hovhannisyan","year":"2011","journal-title":"Gastroenterology"},{"key":"2026090710434107500_vkag145-B44","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1084\/jem.20080034","article-title":"In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells","volume":"205","author":"Lochner","year":"2008","journal-title":"J Exp Med"},{"key":"2026090710434107500_vkag145-B45","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/nature06878","article-title":"TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function","volume":"453","author":"Zhou","year":"2008","journal-title":"Nature"},{"key":"2026090710434107500_vkag145-B46","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1053\/j.gastro.2005.03.043","article-title":"Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease","volume":"128","author":"Maul","year":"2005","journal-title":"Gastroenterology"},{"key":"2026090710434107500_vkag145-B47","doi-asserted-by":"crossref","first-page":"e2250007","DOI":"10.1002\/eji.202250007","article-title":"Regulatory T cells as a therapeutic approach for inflammatory bowel disease","volume":"53","author":"Laukova","year":"2023","journal-title":"Eur J Immunol"},{"key":"2026090710434107500_vkag145-B48","doi-asserted-by":"crossref","first-page":"716499","DOI":"10.3389\/fimmu.2021.716499","article-title":"Intestinal regulatory T cells as specialized tissue-restricted immune cells in intestinal immune homeostasis and disease","volume":"12","author":"Jacobse","year":"2021","journal-title":"Front Immunol"},{"key":"2026090710434107500_vkag145-B49","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.3748\/wjg.v22.i7.2195","article-title":"Role of regulatory T cell in the pathogenesis of inflammatory bowel disease","volume":"22","author":"Yamada","year":"2016","journal-title":"World J Gastroenterol"},{"key":"2026090710434107500_vkag145-B50","doi-asserted-by":"crossref","first-page":"6997","DOI":"10.4049\/jimmunol.180.10.6997","article-title":"Development of inflammatory bowel disease in Long-Evans Cinnamon rats based on CD4+CD25+Foxp3+ regulatory T cell dysfunction","volume":"180","author":"Ishimaru","year":"2008","journal-title":"J Immunol"},{"key":"2026090710434107500_vkag145-B51","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.3390\/cells10081847","article-title":"Translating Treg therapy for inflammatory bowel disease in humanized mice","volume":"10","author":"Negi","year":"2021","journal-title":"Cells"},{"key":"2026090710434107500_vkag145-B52","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1093\/ibd\/izaf141","article-title":"Novel autologous regulatory T-cell therapy ameliorates DSS-induced colitis in humanized mice","volume":"31","author":"Khan","year":"2025","journal-title":"Inflamm Bowel Dis"},{"key":"2026090710434107500_vkag145-B53","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1084\/jem.20080707","article-title":"Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity","volume":"205","author":"Zhou","year":"2008","journal-title":"J Exp Med"},{"key":"2026090710434107500_vkag145-B54","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/ni876","article-title":"Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement","volume":"4","author":"Su","year":"2003","journal-title":"Nat Immunol"},{"key":"2026090710434107500_vkag145-B55","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"2026090710434107500_vkag145-B56","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2026090710434107500_vkag145-B57","doi-asserted-by":"crossref","first-page":"114090","DOI":"10.1016\/j.celrep.2024.114090","article-title":"Nucleation and spreading maintain Polycomb domains every cell cycle","volume":"43","author":"Veronezi","year":"2024","journal-title":"Cell Rep"},{"key":"2026090710434107500_vkag145-B58","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1084\/jem.20040139","article-title":"In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes","volume":"199","author":"Tang","year":"2004","journal-title":"J Exp Med"},{"key":"2026090710434107500_vkag145-B59","doi-asserted-by":"crossref","first-page":"6725","DOI":"10.4049\/jimmunol.178.11.6725","article-title":"Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta","volume":"178","author":"Xu","year":"2007","journal-title":"J Immunol"},{"key":"2026090710434107500_vkag145-B60","doi-asserted-by":"crossref","first-page":"E3432","DOI":"10.1073\/pnas.1408780111","article-title":"Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions","volume":"111","author":"Lu","year":"2014","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026090710434107500_vkag145-B61","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.4049\/jimmunol.1003099","article-title":"Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes","volume":"186","author":"McClymont","year":"2011","journal-title":"J Immunol"},{"key":"2026090710434107500_vkag145-B62","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nm.2389","article-title":"Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease","volume":"17","author":"Dominguez-Villar","year":"2011","journal-title":"Nat Med"},{"key":"2026090710434107500_vkag145-B63","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1084\/jem.20161104","article-title":"Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths","volume":"214","author":"Pelly","year":"2017","journal-title":"J Exp Med"},{"key":"2026090710434107500_vkag145-B64","doi-asserted-by":"crossref","first-page":"5778","DOI":"10.4049\/jimmunol.0901948","article-title":"Synergistic effect of IL-6 and IL-4 in driving fate revision of natural Foxp3+ regulatory T cells","volume":"185","author":"Kastner","year":"2010","journal-title":"J Immunol"},{"key":"2026090710434107500_vkag145-B65","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nature09447","article-title":"Generation of pathogenic T(H)17 cells in the absence of TGF-\u03b2 signalling","volume":"467","author":"Ghoreschi","year":"2010","journal-title":"Nature"},{"key":"2026090710434107500_vkag145-B66","doi-asserted-by":"crossref","first-page":"eabe4723","DOI":"10.1126\/sciimmunol.abe4723","article-title":"Unstable regulatory T cells, enriched for na\u00efve and Nrp1negcells, are purged after fate challenge","volume":"6","author":"Junius","year":"2021","journal-title":"Sci Immunol"},{"key":"2026090710434107500_vkag145-B67","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.immuni.2013.01.013","article-title":"An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos","volume":"38","author":"Sharma","year":"2013","journal-title":"Immunity"},{"key":"2026090710434107500_vkag145-B68","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1073\/pnas.0811556106","article-title":"Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity","volume":"106","author":"Komatsu","year":"2009","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026090710434107500_vkag145-B69","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1016\/j.ymthe.2020.07.020","article-title":"CD4+CD126low\/- Foxp3+ cell population represents a superior subset of regulatory T cells in treating autoimmune diseases","volume":"28","author":"Chen","year":"2020","journal-title":"Mol Ther"},{"key":"2026090710434107500_vkag145-B70","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.immuni.2013.09.012","article-title":"The polycomb protein Ezh2 regulates differentiation and plasticity of CD4(+) T helper type 1 and type 2 cells","volume":"39","author":"Tumes","year":"2013","journal-title":"Immunity"},{"key":"2026090710434107500_vkag145-B71","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1038\/onc.2016.502","article-title":"Census and evaluation of p53 target genes","volume":"36","author":"Fischer","year":"2017","journal-title":"Oncogene"},{"key":"2026090710434107500_vkag145-B72","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/s41418-022-00976-3","article-title":"The TP53 database: transition from the international agency for research on cancer to the US national cancer institute","volume":"29","author":"de Andrade","year":"2022","journal-title":"Cell Death Differ"},{"key":"2026090710434107500_vkag145-B73","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/387299a0","article-title":"Regulation of p53 stability by Mdm2","volume":"387","author":"Kubbutat","year":"1997","journal-title":"Nature"},{"key":"2026090710434107500_vkag145-B74","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/387296a0","article-title":"Mdm2 promotes the rapid degradation of p53","volume":"387","author":"Haupt","year":"1997","journal-title":"Nature"},{"key":"2026090710434107500_vkag145-B75","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","article-title":"Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells","volume":"441","author":"Bettelli","year":"2006","journal-title":"Nature"},{"key":"2026090710434107500_vkag145-B76","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.immuni.2006.01.001","article-title":"TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells","volume":"24","author":"Veldhoen","year":"2006","journal-title":"Immunity"},{"key":"2026090710434107500_vkag145-B77","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature04754","article-title":"Transforming growth factor-beta induces development of the T(H)17 lineage","volume":"441","author":"Mangan","year":"2006","journal-title":"Nature"},{"key":"2026090710434107500_vkag145-B78","doi-asserted-by":"crossref","first-page":"17003","DOI":"10.1074\/jbc.M801286200","article-title":"Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat","volume":"283","author":"Ichiyama","year":"2008","journal-title":"J Biol Chem"},{"key":"2026090710434107500_vkag145-B79","doi-asserted-by":"crossref","first-page":"7995","DOI":"10.1074\/jbc.M109.047985","article-title":"Foxp3 expression in p53-dependent DNA damage responses","volume":"285","author":"Jung","year":"2010","journal-title":"J Biol Chem"},{"key":"2026090710434107500_vkag145-B80","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.cell.2011.07.033","article-title":"Control of T(H)17\/T(reg) balance by hypoxia-inducible factor 1","volume":"146","author":"Dang","year":"2011","journal-title":"Cell"},{"key":"2026090710434107500_vkag145-B81","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41598-017-00508-x","article-title":"IL-1\u03b2 induced HIF-1\u03b1 inhibits the differentiation of human FOXP3+ T cells","volume":"7","author":"Feldhoff","year":"2017","journal-title":"Sci Rep"},{"key":"2026090710434107500_vkag145-B82","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1084\/jem.20110278","article-title":"HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells","volume":"208","author":"Shi","year":"2011","journal-title":"J Exp Med"},{"key":"2026090710434107500_vkag145-B83","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1038\/ni.3577","article-title":"Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression","volume":"17","author":"Gerriets","year":"2016","journal-title":"Nat Immunol"},{"key":"2026090710434107500_vkag145-B84","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/ni.3077","article-title":"Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability","volume":"16","author":"Huynh","year":"2015","journal-title":"Nat Immunol"},{"key":"2026090710434107500_vkag145-B85","doi-asserted-by":"crossref","first-page":"6048","DOI":"10.1158\/0008-5472.CAN-14-1450","article-title":"Reducing CD73 expression by IL1\u03b2-Programmed Th17 cells improves immunotherapeutic control of tumors","volume":"74","author":"Chatterjee","year":"2014","journal-title":"Cancer Res"},{"key":"2026090710434107500_vkag145-B86","doi-asserted-by":"crossref","first-page":"5229","DOI":"10.1158\/0008-5472.CAN-15-1798","article-title":"Lack of p53 augments antitumor functions in cytolytic T cells","volume":"76","author":"Banerjee","year":"2016","journal-title":"Cancer Res"},{"key":"2026090710434107500_vkag145-B87","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cell.2006.05.036","article-title":"TIGAR, a p53-inducible regulator of glycolysis and apoptosis","volume":"126","author":"Bensaad","year":"2006","journal-title":"Cell"},{"key":"2026090710434107500_vkag145-B88","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1126\/science.1126863","article-title":"P53 regulates mitochondrial respiration","volume":"312","author":"Matoba","year":"2006","journal-title":"Science"},{"key":"2026090710434107500_vkag145-B89","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1101\/gad.14.1.34","article-title":"Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1\u03b1","volume":"14","author":"Ravi","year":"2000","journal-title":"Genes Dev"},{"key":"2026090710434107500_vkag145-B90","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1042\/bj20031299","article-title":"p300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1)","volume":"380","author":"Schmid","year":"2004","journal-title":"Biochem J"},{"key":"2026090710434107500_vkag145-B91","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.cmet.2022.02.015","article-title":"The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming","volume":"34","author":"Hochrein","year":"2022","journal-title":"Cell Metab"},{"key":"2026090710434107500_vkag145-B92","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1172\/JCI83084","article-title":"FOXP3+ regulatory T cell development and function require histone\/protein deacetylase 3","volume":"125","author":"Wang","year":"2015","journal-title":"J Clin Invest"},{"key":"2026090710434107500_vkag145-B93","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1002\/ijc.29979","article-title":"HDAC5 controls the functions of Foxp3(+) T-regulatory and CD8(+) T cells","volume":"138","author":"Xiao","year":"2016","journal-title":"Int J Cancer"},{"key":"2026090710434107500_vkag145-B94","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/nm1652","article-title":"Deacetylase inhibition promotes the generation and function of regulatory T cells","volume":"13","author":"Tao","year":"2007","journal-title":"Nat Med"},{"key":"2026090710434107500_vkag145-B95","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1053\/j.gastro.2009.10.037","article-title":"Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice","volume":"138","author":"de Zoeten","year":"2010","journal-title":"Gastroenterology"},{"key":"2026090710434107500_vkag145-B96","doi-asserted-by":"crossref","first-page":"8626","DOI":"10.1038\/s41598-017-09211-3","article-title":"Histone\/protein deacetylase 11 targeting promotes Foxp3+ Treg function","volume":"7","author":"Huang","year":"2017","journal-title":"Sci Rep"},{"key":"2026090710434107500_vkag145-B97","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jcmgh.2018.08.009","article-title":"Disruption of FOXP3-EZH2 interaction represents a pathobiological mechanism in intestinal inflammation","volume":"7","author":"Bamidele","year":"2019","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"2026090710434107500_vkag145-B98","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.3390\/cancers14143451","article-title":"TP53-status-dependent oncogenic EZH2 activity in pancreatic cancer","volume":"14","author":"Versemann","year":"2022","journal-title":"Cancers (Basel)"},{"key":"2026090710434107500_vkag145-B99","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/s41375-020-01023-1","article-title":"PRC2 insufficiency causes p53-dependent dyserythropoiesis in myelodysplastic syndrome","volume":"35","author":"Aoyama","year":"2021","journal-title":"Leukemia"},{"key":"2026090710434107500_vkag145-B100","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.4049\/jimmunol.1700319","article-title":"EZH2 regulates the developmental timing of effectors of the pre-antigen receptor checkpoints","volume":"198","author":"Jacobsen","year":"2017","journal-title":"J Immunol"},{"key":"2026090710434107500_vkag145-B101","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1038\/ni1536","article-title":"CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells","volume":"8","author":"Pandiyan","year":"2007","journal-title":"Nat Immunol"},{"key":"2026090710434107500_vkag145-B102","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.immuni.2007.03.014","article-title":"T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation","volume":"26","author":"Li","year":"2007","journal-title":"Immunity"},{"key":"2026090710434107500_vkag145-B103","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/0092-8674(90)90113-S","article-title":"Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53","volume":"62","author":"Michalovitz","year":"1990","journal-title":"Cell"},{"key":"2026090710434107500_vkag145-B104","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.cell.2014.05.051","article-title":"p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer","volume":"158","author":"Tschaharganeh","year":"2014","journal-title":"Cell"},{"key":"2026090710434107500_vkag145-B105","first-page":"313","article-title":"Meth A fibrosarcoma cells express two transforming mutant p53 species","volume":"3","author":"Eliyahu","year":"1988","journal-title":"Oncogene"},{"key":"2026090710434107500_vkag145-B106","doi-asserted-by":"crossref","first-page":"8763","DOI":"10.1073\/pnas.86.22.8763","article-title":"Wild-type p53 can inhibit oncogene-mediated focus formation","volume":"86","author":"Eliyahu","year":"1989","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026090710434107500_vkag145-B107","doi-asserted-by":"crossref","first-page":"5635","DOI":"10.1158\/0008-5472.CAN-12-1451","article-title":"Multiple roles of p53-related pathways in somatic cell reprogramming and stem cell differentiation","volume":"72","author":"Yi","year":"2012","journal-title":"Cancer Res"},{"key":"2026090710434107500_vkag145-B108","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/cdd.2012.125","article-title":"P53 counteracts reprogramming by inhibiting mesenchymal-to-epithelial transition","volume":"20","author":"Brosh","year":"2013","journal-title":"Cell Death Differ"},{"key":"2026090710434107500_vkag145-B109","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.stemcr.2014.07.006","article-title":"Transient p53 suppression increases reprogramming of human fibroblasts without affecting apoptosis and DNA damage","volume":"3","author":"Rasmussen","year":"2014","journal-title":"Stem Cell Rep"},{"key":"2026090710434107500_vkag145-B110","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/nature08311","article-title":"Linking the p53 tumour suppressor pathway to somatic cell reprogramming","volume":"460","author":"Kawamura","year":"2009","journal-title":"Nature"},{"key":"2026090710434107500_vkag145-B111","first-page":"6304","article-title":"Participation of p53 protein in the cellular response to DNA damage","volume":"51","author":"Kastan","year":"1991","journal-title":"Cancer Res"},{"key":"2026090710434107500_vkag145-B112","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0092-8674(93)90499-G","article-title":"The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases","volume":"75","author":"Harper","year":"1993","journal-title":"Cell"},{"key":"2026090710434107500_vkag145-B113","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/362849a0","article-title":"Thymocyte apoptosis induced by p53-dependent and independent pathways","volume":"362","author":"Clarke","year":"1993","journal-title":"Nature"},{"key":"2026090710434107500_vkag145-B114","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/362847a0","article-title":"P53 is required for radiation-induced apoptosis in mouse thymocytes","volume":"362","author":"Lowe","year":"1993","journal-title":"Nature"},{"key":"2026090710434107500_vkag145-B115","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/352345a0","article-title":"Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6","volume":"352","author":"Yonish-Rouach","year":"1991","journal-title":"Nature"},{"key":"2026090710434107500_vkag145-B116","first-page":"1799","article-title":"Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo","volume":"9","author":"Miyashita","year":"1994","journal-title":"Oncogene"},{"key":"2026090710434107500_vkag145-B117","doi-asserted-by":"crossref","first-page":"110934","DOI":"10.1016\/j.celrep.2022.110934","article-title":"HIF-1\u03b1 is a metabolic switch between glycolytic-driven migration and oxidative phosphorylation-driven immunosuppression of Tregs in glioblastoma","volume":"39","author":"Miska","year":"2022","journal-title":"Cell Rep"},{"key":"2026090710434107500_vkag145-B118","doi-asserted-by":"crossref","first-page":"10493","DOI":"10.1074\/jbc.REV120.011188","article-title":"Oxygen battle in the gut: hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine","volume":"295","author":"Singhal","year":"2020","journal-title":"J Biol Chem"},{"key":"2026090710434107500_vkag145-B119","doi-asserted-by":"crossref","first-page":"106120","DOI":"10.1016\/j.phrs.2022.106120","article-title":"CX-5461 is a potent immunosuppressant which inhibits T cell-mediated alloimmunity via p53-DUSP5","volume":"177","author":"Pan","year":"2022","journal-title":"Pharmacol Res"},{"key":"2026090710434107500_vkag145-B120","doi-asserted-by":"crossref","first-page":"728381","DOI":"10.3389\/fimmu.2021.728381","article-title":"P53 activation effect in the balance of T regulatory and effector cell subsets in patients with thyroid cancer and autoimmunity","volume":"12","author":"Arena","year":"2021","journal-title":"Front Immunol"},{"key":"2026090710434107500_vkag145-B121","doi-asserted-by":"crossref","first-page":"1166135","DOI":"10.3389\/fimmu.2023.1166135","article-title":"Opportunities for Treg cell therapy for the treatment of human disease","volume":"14","author":"Bluestone","year":"2023","journal-title":"Front Immunol"},{"key":"2026090710434107500_vkag145-B122","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.it.2023.04.005","article-title":"Engineered Treg cells as putative therapeutics against inflammatory diseases and beyond","volume":"44","author":"Bittner","year":"2023","journal-title":"Trends Immunol"},{"key":"2026090710434107500_vkag145-B123","doi-asserted-by":"publisher","first-page":"5877","DOI":"10.3390\/cancers15245877","article-title":"Promises and pitfalls of next-generation Treg adoptive immunotherapy","volume":"15","author":"Christofi","year":"2023","journal-title":"Cancers (Basel)"},{"key":"2026090710434107500_vkag145-B124","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1136\/gutjnl-2022-327075","article-title":"Autologous regulatory T-cell transfer in refractory ulcerative colitis with concomitant primary sclerosing cholangitis","volume":"72","author":"Voskens","year":"2023","journal-title":"Gut"},{"key":"2026090710434107500_vkag145-B125","doi-asserted-by":"crossref","first-page":"102961","DOI":"10.1016\/j.jaut.2022.102961","article-title":"Flagellin-specific human CAR Tregs for immune regulation in IBD","volume":"134","author":"Boardman","year":"2023","journal-title":"J Autoimmun"},{"key":"2026090710434107500_vkag145-B126","doi-asserted-by":"publisher","first-page":"jjae135","DOI":"10.1093\/ecco-jcc\/jjae135","article-title":"IL23R-specific CAR Tregs for the treatment of Crohn\u2019s disease","volume":"19","author":"Cui","year":"2025","journal-title":"J Crohns Colitis"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/215\/6\/vkag145\/68711746\/vkag145.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/215\/6\/vkag145\/68711746\/vkag145.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:44:02Z","timestamp":1788792242000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/doi\/10.1093\/jimmun\/vkag145\/8726643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":126,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,7]]}},"URL":"https:\/\/doi.org\/10.1093\/jimmun\/vkag145","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6]]},"published":{"date-parts":[[2026,6]]},"article-number":"vkag145"}}