{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:02:26Z","timestamp":1784674946727,"version":"3.55.0"},"reference-count":161,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100010327","name":"Cincinnati Children\u2019s Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010327","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01AR073228"],"award-info":[{"award-number":["R01AR073228"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01AI148080"],"award-info":[{"award-number":["R01AI148080"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01AI176519"],"award-info":[{"award-number":["R01AI176519"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Department of Defense Award","award":["HT94252410964"],"award-info":[{"award-number":["HT94252410964"]}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences of the NIH","doi-asserted-by":"crossref","award":["UL1TR001425"],"award-info":[{"award-number":["UL1TR001425"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences of the NIH","doi-asserted-by":"crossref","award":["UM1TR005265"],"award-info":[{"award-number":["UM1TR005265"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>NK cells are classically defined by their rapid cytotoxicity against tumor cells and infected cells and by early inflammatory cytokine production. However, unconventional roles for NK cells as regulators of immunity and tissue homeostasis have recently been uncovered. Beyond their classical roles, NK cells can orchestrate leukocyte trafficking, curtail responses of other immune cells, remove protein aggregates, support pregnancy, and contribute to healthy tissue regeneration. We discuss the importance of these myriad functional activities of NK cells in infection, cancer, autoimmunity, atopic and allergic disease, pregnancy, tissue injury, and neurodegenerative diseases. The functional pleiotropy of NK cells provides new avenues of translational utility for these innate lymphocytes and represents an unexplored complexity in conventional clinical applications of NK cells against infection and cancer.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag148","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:01:38Z","timestamp":1784646098000},"source":"Crossref","is-referenced-by-count":0,"title":["Unconventional functions of natural killer cells in homeostasis and disease"],"prefix":"10.1093","volume":"215","author":[{"given":"Anusha","family":"Anukanth","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Cincinnati College of Medicine , Cincinnati, OH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9658-2874","authenticated-orcid":false,"given":"Stephen N","family":"Waggoner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati College of Medicine , Cincinnati, OH,","place":["United States"]},{"name":"Center for Autoimmune Genomics & Etiology, Division of Human Genetics, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"2026072118163980500_vkag148-B1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/jleuko\/qiad027","article-title":"Deciphering the localization and trajectory of human natural killer cell development","volume":"114","author":"Hegewisch-Solloa","year":"2023","journal-title":"J Leukoc Biol"},{"key":"2026072118163980500_vkag148-B2","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/nri.2016.34","article-title":"Emerging insights into natural killer cells in human peripheral tissues","volume":"16","author":"Bjorkstrom","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"2026072118163980500_vkag148-B3","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jaci.2022.09.022","article-title":"Human natural killer cells: form, function, and development","volume":"151","author":"Mace","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"2026072118163980500_vkag148-B4","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nri3044","article-title":"NK cell development, homeostasis and function: parallels with CD8 T cells","volume":"11","author":"Sun","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"2026072118163980500_vkag148-B5","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ni1582","article-title":"Functions of natural killer cells","volume":"9","author":"Vivier","year":"2008","journal-title":"Nat Immunol"},{"key":"2026072118163980500_vkag148-B6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev-immunol-020711-075005","article-title":"Controlling natural killer cell responses: integration of signals for activation and inhibition","volume":"31","author":"Long","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"2026072118163980500_vkag148-B7","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nature03847","article-title":"Licensing of natural killer cells by host major histocompatibility complex class I molecules","volume":"436","author":"Kim","year":"2005","journal-title":"Nature"},{"key":"2026072118163980500_vkag148-B8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0167-5699(90)90097-S","article-title":"In search of the 'missing self\u2019: MHC molecules and NK cell recognition","volume":"11","author":"Ljunggren","year":"1990","journal-title":"Immunol Today"},{"key":"2026072118163980500_vkag148-B9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.immuni.2005.11.010","article-title":"Fcgamma receptors: old friends and new family members","volume":"24","author":"Nimmerjahn","year":"2006","journal-title":"Immunity"},{"key":"2026072118163980500_vkag148-B10","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.0105-2896.2010.00914.x","article-title":"Anatomy of a murder: how cytotoxic T cells and NK cells are activated, develop, and eliminate their targets","volume":"235","author":"Lieberman","year":"2010","journal-title":"Immunol Rev"},{"key":"2026072118163980500_vkag148-B11","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/nri3839","article-title":"Perforin and granzymes: function, dysfunction and human pathology","volume":"15","author":"Voskoboinik","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"2026072118163980500_vkag148-B12","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1002\/JLB.MR0718-269R","article-title":"Mechanisms of natural killer cell-mediated cellular cytotoxicity","volume":"105","author":"Prager","year":"2019","journal-title":"J Leukoc Biol"},{"key":"2026072118163980500_vkag148-B13","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41577-021-00558-3","article-title":"Natural killer cells in antiviral immunity","volume":"22","author":"Bjorkstrom","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"2026072118163980500_vkag148-B14","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/s41573-022-00413-7","article-title":"Harnessing natural killer cells for cancer immunotherapy: dispatching the first responders","volume":"21","author":"Maskalenko","year":"2022","journal-title":"Nat Rev Drug Discov"},{"key":"2026072118163980500_vkag148-B15","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/imr.12725","article-title":"Emerging insights into human health and NK cell biology from the study of NK cell deficiencies","volume":"287","author":"Mace","year":"2019","journal-title":"Immunol Rev"},{"key":"2026072118163980500_vkag148-B16","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1006\/geno.1997.4667","article-title":"The Cmv1 host resistance locus is closely linked to the Ly49 multigene family within the natural killer cell gene complex on mouse chromosome 6","volume":"41","author":"Forbes","year":"1997","journal-title":"Genomics"},{"key":"2026072118163980500_vkag148-B17","doi-asserted-by":"crossref","first-page":"eado6606","DOI":"10.1126\/scitranslmed.ado6606","article-title":"An altered natural killer cell immunophenotype characterizes clinically severe pediatric RSV infection","volume":"16","author":"Reilly","year":"2024","journal-title":"Sci Transl Med"},{"key":"2026072118163980500_vkag148-B18","doi-asserted-by":"crossref","first-page":"eadi3974","DOI":"10.1126\/sciimmunol.adi3974","article-title":"Antigen-specific memory NK cell responses against HIV and influenza use the NKG2\/HLA-E axis","volume":"8","author":"Jost","year":"2023","journal-title":"Sci Immunol"},{"key":"2026072118163980500_vkag148-B19","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev-immunol-101819-074948","article-title":"Natural killer cells: from innate to adaptive features","volume":"39","author":"Mujal","year":"2021","journal-title":"Annu Rev Immunol"},{"key":"2026072118163980500_vkag148-B20","doi-asserted-by":"crossref","first-page":"eaat8116","DOI":"10.1126\/sciimmunol.aat8116","article-title":"Human natural killer cells mediate adaptive immunity to viral antigens","volume":"4","author":"Nikzad","year":"2019","journal-title":"Sci Immunol"},{"key":"2026072118163980500_vkag148-B21","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/S0140-6736(00)03231-1","article-title":"Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population","volume":"356","author":"Imai","year":"2000","journal-title":"Lancet"},{"key":"2026072118163980500_vkag148-B22","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41568-020-0272-z","article-title":"The cancer-natural killer cell immunity cycle","volume":"20","author":"Huntington","year":"2020","journal-title":"Nat Rev Cancer"},{"key":"2026072118163980500_vkag148-B23","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/s41586-023-06945-1","article-title":"Natural killer cell therapies","volume":"626","author":"Vivier","year":"2024","journal-title":"Nature"},{"key":"2026072118163980500_vkag148-B24","doi-asserted-by":"crossref","first-page":"357ra123","DOI":"10.1126\/scitranslmed.aaf2341","article-title":"Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia","volume":"8","author":"Romee","year":"2016","journal-title":"Sci Transl Med"},{"key":"2026072118163980500_vkag148-B25","doi-asserted-by":"crossref","first-page":"4751","DOI":"10.1182\/blood-2012-04-419283","article-title":"Cytokine activation induces human memory-like NK cells","volume":"120","author":"Romee","year":"2012","journal-title":"Blood"},{"key":"2026072118163980500_vkag148-B26","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/JLB.3MR0820-685R","article-title":"Regulatory functions of NK cells during infections and cancer","volume":"109","author":"Zwirner","year":"2021","journal-title":"J Leukoc Biol"},{"key":"2026072118163980500_vkag148-B27","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/nri956","article-title":"Natural killer cells and dendritic cells: rendezvous in abused tissues","volume":"2","author":"Moretta","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"2026072118163980500_vkag148-B28","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1038\/ni1138","article-title":"Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming","volume":"5","author":"Martin-Fontecha","year":"2004","journal-title":"Nat Immunol"},{"key":"2026072118163980500_vkag148-B29","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1016\/j.celrep.2019.01.104","article-title":"Influenza vaccination induces NK-cell-mediated Type-II IFN response that regulates humoral immunity in an IL-6-dependent manner","volume":"26","author":"Farsakoglu","year":"2019","journal-title":"Cell Rep"},{"key":"2026072118163980500_vkag148-B30","doi-asserted-by":"crossref","first-page":"E5688","DOI":"10.1073\/pnas.1411072112","article-title":"Licensed human natural killer cells aid dendritic cell maturation via TNFSF14\/LIGHT","volume":"111","author":"Holmes","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026072118163980500_vkag148-B31","doi-asserted-by":"crossref","first-page":"1058894","DOI":"10.3389\/fonc.2022.1058894","article-title":"NK cells reduce anergic T cell development in early-stage tumors by promoting myeloid cell maturation","volume":"12","author":"Lindsay","year":"2022","journal-title":"Front Oncol"},{"key":"2026072118163980500_vkag148-B32","doi-asserted-by":"crossref","first-page":"5133","DOI":"10.1182\/blood-2010-12-324632","article-title":"Self MHC class I-licensed NK cells enhance adaptive CD8 T-cell viral immunity","volume":"117","author":"Stadnisky","year":"2011","journal-title":"Blood"},{"key":"2026072118163980500_vkag148-B33","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1615\/CritRevOncog.2014010827","article-title":"Dendritic cell editing by natural killer cells","volume":"19","author":"Ferlazzo","year":"2014","journal-title":"Crit Rev Oncog"},{"key":"2026072118163980500_vkag148-B34","doi-asserted-by":"crossref","first-page":"6593","DOI":"10.1182\/blood-2009-01-201467","article-title":"NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responses","volume":"113","author":"Krebs","year":"2009","journal-title":"Blood"},{"key":"2026072118163980500_vkag148-B35","doi-asserted-by":"crossref","first-page":"6140","DOI":"10.4049\/jimmunol.178.10.6140","article-title":"NK cells negatively regulate antigen presentation and tumor-specific CTLs in a syngeneic lymphoma model","volume":"178","author":"Barber","year":"2007","journal-title":"J Immunol"},{"key":"2026072118163980500_vkag148-B36","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1084\/jem.20091193","article-title":"Innate immunity defines the capacity of antiviral T cells to limit persistent infection","volume":"207","author":"Andrews","year":"2010","journal-title":"J Exp Med"},{"key":"2026072118163980500_vkag148-B37","doi-asserted-by":"crossref","first-page":"641","DOI":"10.4049\/jimmunol.1202448","article-title":"The depletion of NK cells prevents T cell exhaustion to efficiently control disseminating virus infection","volume":"190","author":"Cook","year":"2013","journal-title":"J Immunol"},{"key":"2026072118163980500_vkag148-B38","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3389\/fimmu.2020.00197","article-title":"The variable genomic NK cell receptor locus is a key determinant of CD4+ T cell responses during viral infection","volume":"11","author":"Raynor","year":"2020","journal-title":"Front Immunol"},{"key":"2026072118163980500_vkag148-B39","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.chom.2009.11.003","article-title":"Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cells","volume":"6","author":"Perona-Wright","year":"2009","journal-title":"Cell Host Microbe"},{"key":"2026072118163980500_vkag148-B40","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1084\/jem.20082387","article-title":"Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infection","volume":"206","author":"Lee","year":"2009","journal-title":"J Exp Med"},{"key":"2026072118163980500_vkag148-B41","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.immuni.2018.03.012","article-title":"Interleukin-15 complex treatment protects mice from cerebral malaria by inducing interleukin-10-producing natural killer cells","volume":"48","author":"Burrack","year":"2018","journal-title":"Immunity"},{"key":"2026072118163980500_vkag148-B42","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.4049\/jimmunol.2001131","article-title":"NK cell-derived IL-10 supports host survival during sepsis","volume":"206","author":"Jensen","year":"2021","journal-title":"J Immunol"},{"key":"2026072118163980500_vkag148-B43","doi-asserted-by":"crossref","first-page":"e183076","DOI":"10.1172\/jci.insight.183076","article-title":"Phenotype and function of IL-10-producing NK cells in individuals with malaria experience","volume":"10","author":"McNitt","year":"2025","journal-title":"JCI Insight"},{"key":"2026072118163980500_vkag148-B44","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/eji.200635989","article-title":"Increased natural cytotoxicity receptor expression and relevant IL-10 production in NK cells from chronically infected viremic HCV patients","volume":"37","author":"De Maria","year":"2007","journal-title":"Eur J Immunol"},{"key":"2026072118163980500_vkag148-B45","doi-asserted-by":"crossref","first-page":"e1005708","DOI":"10.1371\/journal.ppat.1005708","article-title":"Bacterial manipulation of NK cell regulatory activity increases susceptibility to listeria monocytogenes infection","volume":"12","author":"Clark","year":"2016","journal-title":"PLoS Pathog"},{"key":"2026072118163980500_vkag148-B46","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1172\/JCI128895","article-title":"CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment","volume":"130","author":"Neo","year":"2020","journal-title":"J Clin Invest"},{"key":"2026072118163980500_vkag148-B47","doi-asserted-by":"crossref","first-page":"eadi2952","DOI":"10.1126\/scitranslmed.adi2952","article-title":"Tumor-associated NK cells drive MDSC-mediated tumor immune tolerance through the IL-6\/STAT3 axis","volume":"16","author":"Neo","year":"2024","journal-title":"Sci Transl Med"},{"key":"2026072118163980500_vkag148-B48","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/JLB.MA0618-231R","article-title":"CRTAM(+) NK cells endowed with suppressor properties arise in leukemic bone marrow","volume":"105","author":"Ramirez-Ramirez","year":"2019","journal-title":"J Leukoc Biol"},{"key":"2026072118163980500_vkag148-B49","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nature10624","article-title":"Natural killer cells act as rheostats modulating antiviral T cells","volume":"481","author":"Waggoner","year":"2011","journal-title":"Nature"},{"key":"2026072118163980500_vkag148-B50","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1073\/pnas.1118834109","article-title":"Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity","volume":"109","author":"Lang","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026072118163980500_vkag148-B51","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1084\/jem.20121172","article-title":"Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion","volume":"210","author":"Peppa","year":"2013","journal-title":"J Exp Med"},{"key":"2026072118163980500_vkag148-B52","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.immuni.2014.09.013","article-title":"TRAIL+ NK cells control CD4+ T cell responses during chronic viral infection to limit autoimmunity","volume":"41","author":"Schuster","year":"2014","journal-title":"Immunity"},{"key":"2026072118163980500_vkag148-B53","article-title":"PD-1 mediated regulation of unique activated CD8 (+) T cells by NK cells in the submandibular gland","author":"Borys","year":"2023","journal-title":"bioRxiv"},{"key":"2026072118163980500_vkag148-B54","doi-asserted-by":"crossref","first-page":"eabi4670","DOI":"10.1126\/scitranslmed.abi4670","article-title":"NK cells limit therapeutic vaccine-induced CD8(+)T cell immunity in a PD-L1-dependent manner","volume":"14","author":"Diniz","year":"2022","journal-title":"Sci Transl Med"},{"key":"2026072118163980500_vkag148-B55","doi-asserted-by":"crossref","first-page":"745939","DOI":"10.3389\/fimmu.2021.745939","article-title":"Tumor-experienced human NK cells express high levels of PD-L1 and inhibit CD8(+) T cell proliferation","volume":"12","author":"Sierra","year":"2021","journal-title":"Front Immunol"},{"key":"2026072118163980500_vkag148-B56","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.immuni.2018.12.024","article-title":"Liver-resident NK cells control antiviral activity of hepatic T cells via the PD-1-PD-L1 axis","volume":"50","author":"Zhou","year":"2019","journal-title":"Immunity"},{"key":"2026072118163980500_vkag148-B57","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1158\/2159-8290.CD-24-1232","article-title":"Tumor-associated NK cells regulate distinct CD8+ T-cell differentiation program in cancer and contribute to resistance against immune checkpoint blockers","volume":"15","author":"Song","year":"2025","journal-title":"Cancer Discov"},{"key":"2026072118163980500_vkag148-B58","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nm.4278","article-title":"A distinct innate lymphoid cell population regulates tumor-associated T cells","volume":"23","author":"Crome","year":"2017","journal-title":"Nat Med"},{"key":"2026072118163980500_vkag148-B59","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1172\/JCI41264","article-title":"Absence of mouse 2B4 promotes NK cell-mediated killing of activated CD8+ T cells, leading to prolonged viral persistence and altered pathogenesis","volume":"120","author":"Waggoner","year":"2010","journal-title":"J Clin Invest"},{"key":"2026072118163980500_vkag148-B60","doi-asserted-by":"crossref","first-page":"e31959","DOI":"10.1371\/journal.pone.0031959","article-title":"Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94\/NKG2A","volume":"7","author":"Nielsen","year":"2012","journal-title":"PLoS One"},{"key":"2026072118163980500_vkag148-B61","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2007.03.017","article-title":"Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway","volume":"26","author":"Lu","year":"2007","journal-title":"Immunity"},{"key":"2026072118163980500_vkag148-B62","doi-asserted-by":"crossref","first-page":"eadj7970","DOI":"10.1126\/sciimmunol.adj7970","article-title":"The immunoglobulin superfamily ligand B7H6 subjects T cell responses to NK cell surveillance","volume":"9","author":"Kilian","year":"2024","journal-title":"Sci Immunol"},{"key":"2026072118163980500_vkag148-B63","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/cei.13422","article-title":"Low-dose IL-2 induces CD56(bright) NK regulation of T cells via NKp44 and NKp46","volume":"200","author":"McQuaid","year":"2020","journal-title":"Clin Exp Immunol"},{"key":"2026072118163980500_vkag148-B64","doi-asserted-by":"crossref","first-page":"e1007725","DOI":"10.1371\/journal.ppat.1007725","article-title":"NK cells negatively regulate CD8 T cells via natural cytotoxicity receptor (NCR) 1 during LCMV infection","volume":"15","author":"Pallmer","year":"2019","journal-title":"PLoS Pathog"},{"key":"2026072118163980500_vkag148-B65","doi-asserted-by":"crossref","first-page":"114089","DOI":"10.1016\/j.celrep.2024.114089","article-title":"NKp44\/HLA-DP-dependent regulation of CD8 effector T cells by NK cells","volume":"43","author":"Padoan","year":"2024","journal-title":"Cell Rep"},{"key":"2026072118163980500_vkag148-B66","doi-asserted-by":"crossref","first-page":"e1527498","DOI":"10.1080\/2162402X.2018.1527498","article-title":"Circulating NKp46(+) natural killer cells have a potential regulatory property and predict distinct survival in non-small cell lung cancer","volume":"8","author":"Picard","year":"2019","journal-title":"Oncoimmunology"},{"key":"2026072118163980500_vkag148-B67","doi-asserted-by":"crossref","first-page":"e146686","DOI":"10.1172\/JCI146686","article-title":"Natural killer cell immunosuppressive function requires CXCR3-dependent redistribution within lymphoid tissues","volume":"131","author":"Ali","year":"2021","journal-title":"J Clin Invest"},{"key":"2026072118163980500_vkag148-B68","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.immuni.2014.05.003","article-title":"Type I interferons protect T cells against NK cell attack mediated by the activating receptor NCR1","volume":"40","author":"Crouse","year":"2014","journal-title":"Immunity"},{"key":"2026072118163980500_vkag148-B69","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.immuni.2014.05.004","article-title":"Type I interferon protects antiviral CD8(+) T cells from NK cell cytotoxicity","volume":"40","author":"Xu","year":"2014","journal-title":"Immunity"},{"key":"2026072118163980500_vkag148-B70","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.immuni.2023.01.016","article-title":"Infection induces tissue-resident memory NK cells that safeguard tissue health","volume":"56","author":"Schuster","year":"2023","journal-title":"Immunity"},{"key":"2026072118163980500_vkag148-B71","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1158\/2159-8290.CD-24-1208","article-title":"Cytotoxic NK cells impede response to checkpoint immunotherapy in melanoma with an immune-excluded phenotype","volume":"15","author":"Pozniak","year":"2025","journal-title":"Cancer Discov"},{"key":"2026072118163980500_vkag148-B72","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature07665","article-title":"Adaptive immune features of natural killer cells","volume":"457","author":"Sun","year":"2009","journal-title":"Nature"},{"key":"2026072118163980500_vkag148-B73","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/s41590-018-0082-6","article-title":"Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells","volume":"19","author":"Hammer","year":"2018","journal-title":"Nat Immunol"},{"key":"2026072118163980500_vkag148-B74","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/ni.1953","article-title":"Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses","volume":"11","author":"Paust","year":"2010","journal-title":"Nat Immunol"},{"key":"2026072118163980500_vkag148-B75","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.immuni.2015.02.008","article-title":"Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function","volume":"42","author":"Schlums","year":"2015","journal-title":"Immunity"},{"key":"2026072118163980500_vkag148-B76","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.immuni.2015.02.013","article-title":"Epigenetic modification and antibody-dependent expansion of memory-like NK cells in human cytomegalovirus-infected individuals","volume":"42","author":"Lee","year":"2015","journal-title":"Immunity"},{"key":"2026072118163980500_vkag148-B77","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.tips.2021.06.004","article-title":"Targeting natural killer cells to enhance vaccine responses","volume":"42","author":"Cox","year":"2021","journal-title":"Trends Pharmacol Sci"},{"key":"2026072118163980500_vkag148-B78","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41541-017-0027-3","article-title":"Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFN\u03b3 response promoting vaccine immunogenicity","volume":"2","author":"Coccia","year":"2017","journal-title":"NPJ Vaccines"},{"key":"2026072118163980500_vkag148-B79","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41541-021-00289-5","article-title":"Immunogenicity of standard, high-dose, MF59-adjuvanted, and recombinant-HA seasonal influenza vaccination in older adults","volume":"6","author":"Li","year":"2021","journal-title":"NPJ Vaccines"},{"key":"2026072118163980500_vkag148-B80","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1016\/j.celrep.2018.08.075","article-title":"Affinity maturation is impaired by natural killer cell suppression of germinal centers","volume":"24","author":"Rydyznski","year":"2018","journal-title":"Cell Rep"},{"key":"2026072118163980500_vkag148-B81","doi-asserted-by":"crossref","first-page":"6375","DOI":"10.1038\/ncomms7375","article-title":"Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells","volume":"6","author":"Rydyznski","year":"2015","journal-title":"Nat Commun"},{"key":"2026072118163980500_vkag148-B82","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1189\/jlb.4HI1214-594R","article-title":"NK cells inhibit humoral immunity by reducing the abundance of CD4+ T follicular helper cells during a chronic virus infection","volume":"98","author":"Cook","year":"2015","journal-title":"J Leukoc Biol"},{"key":"2026072118163980500_vkag148-B83","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.4049\/jimmunol.1004122","article-title":"Cutting edge: CD8+ T cell priming in the absence of NK cells leads to enhanced memory responses","volume":"186","author":"Soderquest","year":"2011","journal-title":"J Immunol"},{"key":"2026072118163980500_vkag148-B84","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cell.2018.08.064","article-title":"RAB11FIP5 expression and altered natural killer cell function are associated with induction of HIV broadly neutralizing antibody responses","volume":"175","author":"Bradley","year":"2018","journal-title":"Cell"},{"key":"2026072118163980500_vkag148-B85","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1038\/s41590-025-02341-1","article-title":"Interferon-mediated NK cell activation increases cytolytic activity against T follicular helper cells and limits antibody response to SARS-CoV-2","volume":"26","author":"de Los RiosKobara","year":"2025","journal-title":"Nat Immunol"},{"key":"2026072118163980500_vkag148-B86","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1172\/JCI75429","article-title":"Immune activation alters cellular and humoral responses to yellow fever 17D vaccine","volume":"124","author":"Muyanja","year":"2014","journal-title":"J Clin Invest"},{"key":"2026072118163980500_vkag148-B87","doi-asserted-by":"crossref","first-page":"eaay8618","DOI":"10.1126\/scitranslmed.aay8618","article-title":"Transcriptional profiles of adjuvanted hepatitis B vaccines display variable interindividual homogeneity but a shared core signature","volume":"12","author":"De Mot","year":"2020","journal-title":"Sci Transl Med"},{"key":"2026072118163980500_vkag148-B88","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1073\/pnas.1621489114","article-title":"Systems analysis of protective immune responses to RTS, S malaria vaccination in humans","volume":"114","author":"Kazmin","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026072118163980500_vkag148-B89","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41590-023-01717-5","article-title":"Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults","volume":"25","author":"Ravichandran","year":"2024","journal-title":"Nat Immunol"},{"key":"2026072118163980500_vkag148-B90","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1126\/science.1068440","article-title":"Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants","volume":"295","author":"Ruggeri","year":"2002","journal-title":"Science"},{"key":"2026072118163980500_vkag148-B91","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1172\/JCI1268","article-title":"Suppression of graft-versus-host disease and amplification of graft-versus-tumor effects by activated natural killer cells after allogeneic bone marrow transplantation","volume":"101","author":"Asai","year":"1998","journal-title":"J Clin Invest"},{"key":"2026072118163980500_vkag148-B92","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1182\/blood-2009-05-222190","article-title":"NK cells mediate reduction of GVHD by inhibiting activated, alloreactive T cells while retaining GVT effects","volume":"115","author":"Olson","year":"2010","journal-title":"Blood"},{"key":"2026072118163980500_vkag148-B93","doi-asserted-by":"crossref","first-page":"102062","DOI":"10.1016\/j.jcyt.2026.102062","article-title":"Chronic graft-versus-host disease suppressing CD56(bright)perforin(neg) regulatory-like NK cells inhibit CD4(+) T cells via PD-1, LAG-3, and TRAIL","volume":"28","author":"Lauener","year":"2026","journal-title":"Cytotherapy"},{"key":"2026072118163980500_vkag148-B94","doi-asserted-by":"crossref","first-page":"111416","DOI":"10.1016\/j.isci.2024.111416","article-title":"Single cell profiling of hematopoietic stem cell transplant recipients reveals TGF-\u03b21 and IL-2 confer immunoregulatory functions to NK cells","volume":"27","author":"Mathews","year":"2024","journal-title":"iScience"},{"key":"2026072118163980500_vkag148-B95","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev-immunol-102119-075119","article-title":"Natural killer cells in the human uterine mucosa","volume":"41","author":"Male","year":"2023","journal-title":"Ann Rev Immunol"},{"key":"2026072118163980500_vkag148-B96","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/nm1452","article-title":"Decidual NK cells regulate key developmental processes at the human fetal-maternal interface","volume":"12","author":"Hanna","year":"2006","journal-title":"Nat Med"},{"key":"2026072118163980500_vkag148-B97","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.immuni.2017.11.018","article-title":"Natural killer cells promote fetal development through the secretion of growth-promoting factors","volume":"47","author":"Fu","year":"2017","journal-title":"Immunity"},{"key":"2026072118163980500_vkag148-B98","doi-asserted-by":"crossref","first-page":"821542","DOI":"10.3389\/fimmu.2022.821542","article-title":"Human-induced CD49a(+) NK cells promote fetal growth","volume":"13","author":"Du","year":"2022","journal-title":"Front Immunol"},{"key":"2026072118163980500_vkag148-B99","doi-asserted-by":"crossref","first-page":"e540","DOI":"10.1002\/ctm2.540","article-title":"Decidual CXCR4(+) CD56(bright) NK cells as a novel NK subset in maternal-foetal immune tolerance to alleviate early pregnancy failure","volume":"11","author":"Tao","year":"2021","journal-title":"Clin Transl Med"},{"key":"2026072118163980500_vkag148-B100","doi-asserted-by":"crossref","first-page":"eaah4323","DOI":"10.1126\/scisignal.aah4323","article-title":"Tim-3 signaling in peripheral NK cells promotes maternal-fetal immune tolerance and alleviates pregnancy loss","volume":"10","author":"Li","year":"2017","journal-title":"Sci Signal"},{"key":"2026072118163980500_vkag148-B101","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/cmi.2014.126","article-title":"The Galectin-9\/Tim-3 pathway is involved in the regulation of NK cell function at the maternal-fetal interface in early pregnancy","volume":"13","author":"Li","year":"2016","journal-title":"Cell Mol Immunol"},{"key":"2026072118163980500_vkag148-B102","doi-asserted-by":"crossref","first-page":"E231","DOI":"10.1073\/pnas.1206322110","article-title":"Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface","volume":"110","author":"Fu","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026072118163980500_vkag148-B103","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.cell.2020.07.019","article-title":"Decidual NK cells transfer granulysin to selectively kill bacteria in trophoblasts","volume":"182","author":"Crespo","year":"2020","journal-title":"Cell"},{"key":"2026072118163980500_vkag148-B104","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.4049\/jimmunol.1800475","article-title":"Human NK cells lyse Th2-polarizing dendritic cells via NKp30 and DNAM-1","volume":"201","author":"Walwyn-Brown","year":"2018","journal-title":"J Immunol"},{"key":"2026072118163980500_vkag148-B105","doi-asserted-by":"crossref","first-page":"174ra26","DOI":"10.1126\/scitranslmed.3004812","article-title":"Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma","volume":"5","author":"Barnig","year":"2013","journal-title":"Sci Transl Med"},{"key":"2026072118163980500_vkag148-B106","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.4049\/jimmunol.1601830","article-title":"NK cells alleviate lung inflammation by negatively regulating group 2 innate lymphoid cells","volume":"198","author":"Bi","year":"2017","journal-title":"J Immunol"},{"key":"2026072118163980500_vkag148-B107","doi-asserted-by":"crossref","first-page":"461","DOI":"10.4049\/jimmunol.1600275","article-title":"PGI2 controls pulmonary NK cells that prevent airway sensitization to house dust mite allergen","volume":"198","author":"Simons","year":"2017","journal-title":"J Immunol"},{"key":"2026072118163980500_vkag148-B108","doi-asserted-by":"crossref","first-page":"eaam5446","DOI":"10.1126\/sciimmunol.aam5446","article-title":"Natural killer cell-mediated inflammation resolution is disabled in severe asthma","volume":"2","author":"Duvall","year":"2017","journal-title":"Sci Immunol"},{"key":"2026072118163980500_vkag148-B109","doi-asserted-by":"crossref","first-page":"850","DOI":"10.4049\/jimmunol.180.2.850","article-title":"Regulatory NK cells suppress antigen-specific T cell responses","volume":"180","author":"Deniz","year":"2008","journal-title":"J Immunol"},{"key":"2026072118163980500_vkag148-B110","doi-asserted-by":"crossref","first-page":"752888","DOI":"10.3389\/fimmu.2021.752888","article-title":"CD1d(hi)PD-L1(hi)CD27(+) regulatory natural killer subset suppresses atopic dermatitis","volume":"12","author":"Min","year":"2021","journal-title":"Front Immunol"},{"key":"2026072118163980500_vkag148-B111","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/scitranslmed.aay1005","article-title":"Blood natural killer cell deficiency reveals an immunotherapy strategy for atopic dermatitis","volume":"12","author":"Mack","year":"2020","journal-title":"Sci Transl Med"},{"key":"2026072118163980500_vkag148-B112","first-page":"3210","article-title":"Ovalbumin induces natural killer cells to secrete Th2 cytokines IL5 and IL13 in a mouse model of asthma","volume":"19","author":"Chen","year":"2019","journal-title":"Mol Med Rep"},{"key":"2026072118163980500_vkag148-B113","doi-asserted-by":"crossref","first-page":"e157962","DOI":"10.1172\/JCI157962","article-title":"Cytometric analysis reveals an association between allergen-responsive natural killer cells and human peanut allergy","volume":"132","author":"Zhou","year":"2022","journal-title":"J Clin Invest"},{"key":"2026072118163980500_vkag148-B114","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1016\/j.jaci.2018.02.019","article-title":"Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma","volume":"142","author":"Altman","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"2026072118163980500_vkag148-B115","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.jaci.2013.09.048","article-title":"Natural killer cell NKG2D and granzyme B are critical for allergic pulmonary inflammation","volume":"133","author":"Farhadi","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"2026072118163980500_vkag148-B116","first-page":"4133","article-title":"Maternal diesel particle exposure promotes offspring asthma through NK cell-derived granzyme B","volume":"130","author":"Qian","year":"2020","journal-title":"J Clin Invest"},{"key":"2026072118163980500_vkag148-B117","doi-asserted-by":"crossref","first-page":"eadd3085","DOI":"10.1126\/sciimmunol.add3085","article-title":"Progressive accumulation of hyperinflammatory NKG2D (low) NK cells in early childhood severe atopic dermatitis","volume":"9","author":"Ochayon","year":"2023","journal-title":"Sci Immunol"},{"key":"2026072118163980500_vkag148-B118","doi-asserted-by":"crossref","first-page":"e20250612","DOI":"10.1084\/jem.20250612","article-title":"Bringing natural killer cells to the clinic: opportunities beyond cancer","volume":"223","author":"Cayatte","year":"2026","journal-title":"J Exp Med"},{"key":"2026072118163980500_vkag148-B119","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13195-025-01681-2","article-title":"Treatment of Alzheimer\u2019s disease subjects with expanded non-genetically modified autologous natural killer cells (SNK01): a phase I study","volume":"17","author":"Zuniga","year":"2025","journal-title":"Alzheimers Res Ther"},{"key":"2026072118163980500_vkag148-B120","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1749-6632.2000.tb05399.x","article-title":"Overproduction of IFN-gamma and TNF-alpha from natural killer (NK) cells is associated with abnormal NK reactivity and cognitive derangement in Alzheimer\u2019s disease","volume":"917","author":"Solerte","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"2026072118163980500_vkag148-B121","doi-asserted-by":"crossref","first-page":"502","DOI":"10.4049\/jimmunol.2000037","article-title":"Depletion of NK cells improves cognitive function in the Alzheimer disease mouse model","volume":"205","author":"Zhang","year":"2020","journal-title":"J Immunol"},{"key":"2026072118163980500_vkag148-B122","doi-asserted-by":"crossref","first-page":"992505","DOI":"10.3389\/fimmu.2022.992505","article-title":"Single-cell RNA sequencing of CSF reveals neuroprotective RAC1(+) NK cells in Parkinson\u2019s disease","volume":"13","author":"Guan","year":"2022","journal-title":"Front Immunol"},{"key":"2026072118163980500_vkag148-B123","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1073\/pnas.1909110117","article-title":"NK cells clear \u03b1-synuclein and the depletion of NK cells exacerbates synuclein pathology in a mouse model of \u03b1-synucleinopathy","volume":"117","author":"Earls","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026072118163980500_vkag148-B124","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1093\/brain\/awaf108","article-title":"CXCR3-mediated natural killer cell infiltration exacerbates white matter injury after intracerebral haemorrhage","volume":"148","author":"Ng","year":"2025","journal-title":"Brain"},{"key":"2026072118163980500_vkag148-B125","doi-asserted-by":"crossref","first-page":"e20200213","DOI":"10.1084\/jem.20200213","article-title":"Brain transforms natural killer cells that exacerbate brain edema after intracerebral hemorrhage","volume":"217","author":"Li","year":"2020","journal-title":"J Exp Med"},{"key":"2026072118163980500_vkag148-B126","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12974-026-03715-4","article-title":"Natural killer cells aggravate neuroinflammation through microglial type I interferon pathway activation after traumatic brain injury","volume":"23","author":"Nie","year":"2026","journal-title":"J Neuroinflammation"},{"key":"2026072118163980500_vkag148-B127","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1038\/s41467-020-15644-8","article-title":"Natural killer cells modulate motor neuron-immune cell cross talk in models of amyotrophic lateral sclerosis","volume":"11","author":"Garofalo","year":"2020","journal-title":"Nat Commun"},{"key":"2026072118163980500_vkag148-B128","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1038\/s41467-023-38899-3","article-title":"Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via interferon-gamma and acetylcholine","volume":"14","author":"Garofalo","year":"2023","journal-title":"Nat Commun"},{"key":"2026072118163980500_vkag148-B129","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.immuni.2025.04.028","article-title":"Maternal natural killer cells drive neuroimmune disorders in offspring through aberrant secretion of extracellular granzyme B","volume":"58","author":"Bian","year":"2025","journal-title":"Immunity"},{"key":"2026072118163980500_vkag148-B130","doi-asserted-by":"crossref","first-page":"e2111445119","DOI":"10.1073\/pnas.2111445119","article-title":"Neutrophil and natural killer cell imbalances prevent muscle stem cell-mediated regeneration following murine volumetric muscle loss","volume":"119","author":"Larouche","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026072118163980500_vkag148-B131","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.ajpath.2014.11.023","article-title":"Natural killer cells limit cardiac inflammation and fibrosis by halting eosinophil infiltration","volume":"185","author":"Ong","year":"2015","journal-title":"Am J Pathol"},{"key":"2026072118163980500_vkag148-B132","doi-asserted-by":"crossref","first-page":"7014","DOI":"10.4049\/jimmunol.1001888","article-title":"Induction of cardiac angiogenesis requires killer cell lectin-like receptor 1 and \u03b14\u03b27 integrin expression by NK cells","volume":"185","author":"Bouchentouf","year":"2010","journal-title":"J Immunol"},{"key":"2026072118163980500_vkag148-B133","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.stemcr.2022.01.006","article-title":"Tissue origin of cytotoxic natural killer cells dictates their differential roles in mouse digit tip regeneration and progenitor cell survival","volume":"17","author":"Dastagir","year":"2022","journal-title":"Stem Cell Reports"},{"key":"2026072118163980500_vkag148-B134","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1038\/s41590-025-02270-z","article-title":"Damage-induced IL-18 stimulates thymic NK cells limiting endogenous tissue regeneration","volume":"26","author":"Granadier","year":"2025","journal-title":"Nat Immunol"},{"key":"2026072118163980500_vkag148-B135","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jhep.2019.03.012","article-title":"KLRG1+ natural killer cells exert a novel antifibrotic function in chronic hepatitis B","volume":"71","author":"Wijaya","year":"2019","journal-title":"J Hepatol"},{"key":"2026072118163980500_vkag148-B136","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/hep.28389","article-title":"NKp46(+) natural killer cells attenuate metabolism-induced hepatic fibrosis by regulating macrophage activation in mice","volume":"63","author":"Tosello-Trampont","year":"2016","journal-title":"Hepatology"},{"key":"2026072118163980500_vkag148-B137","doi-asserted-by":"crossref","first-page":"e3678","DOI":"10.1097\/MD.0000000000003678","article-title":"Accumulation of intrahepatic TNF-\u03b1-producing NKp44+ NK cells correlates with liver fibrosis and viral load in chronic HCV infection","volume":"95","author":"Nel","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"2026072118163980500_vkag148-B138","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.cell.2018.12.022","article-title":"Natural killer cells degenerate intact sensory afferents following nerve injury","volume":"176","author":"Davies","year":"2019","journal-title":"Cell"},{"key":"2026072118163980500_vkag148-B139","doi-asserted-by":"crossref","first-page":"eadi6626","DOI":"10.1126\/scitranslmed.adi6626","article-title":"Natural killer cells promote neutrophil extracellular traps and restrain macular degeneration in mice","volume":"16","author":"Dong","year":"2024","journal-title":"Sci Transl Med"},{"key":"2026072118163980500_vkag148-B140","doi-asserted-by":"crossref","first-page":"622306","DOI":"10.3389\/fimmu.2021.622306","article-title":"The role of natural killer cells in autoimmune diseases","volume":"12","author":"Kucuksezer","year":"2021","journal-title":"Front Immunol"},{"key":"2026072118163980500_vkag148-B141","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/s41584-024-01167-9","article-title":"Epstein-Barr virus as a potentiator of autoimmune diseases","volume":"20","author":"Robinson","year":"2024","journal-title":"Nat Rev Rheumatol"},{"key":"2026072118163980500_vkag148-B142","doi-asserted-by":"crossref","first-page":"5705","DOI":"10.1016\/j.cell.2023.11.015","article-title":"Ineffective control of Epstein-Barr-virus-induced autoimmunity increases the risk for multiple sclerosis","volume":"186","author":"Vietzen","year":"2023","journal-title":"Cell"},{"key":"2026072118163980500_vkag148-B143","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1084\/jem.186.10.1677","article-title":"Regulation of experimental autoimmune encephalomyelitis by natural killer (NK) cells","volume":"186","author":"Zhang","year":"1997","journal-title":"J Exp Med"},{"key":"2026072118163980500_vkag148-B144","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1084\/jem.20092749","article-title":"Central nervous system (CNS)-resident natural killer cells suppress Th17 responses and CNS autoimmune pathology","volume":"207","author":"Hao","year":"2010","journal-title":"J Exp Med"},{"key":"2026072118163980500_vkag148-B145","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41586-020-03116-4","article-title":"Gut-licensed IFN\u03b3(+) NK cells drive LAMP1(+)TRAIL(+) anti-inflammatory astrocytes","volume":"590","author":"Sanmarco","year":"2021","journal-title":"Nature"},{"key":"2026072118163980500_vkag148-B146","doi-asserted-by":"crossref","first-page":"E6202","DOI":"10.1073\/pnas.1705491114","article-title":"Acetylcholine-producing NK cells attenuate CNS inflammation via modulation of infiltrating monocytes\/macrophages","volume":"114","author":"Jiang","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026072118163980500_vkag148-B147","doi-asserted-by":"crossref","first-page":"1230735","DOI":"10.3389\/fimmu.2024.1230735","article-title":"Ozanimod-mediated remission in experimental autoimmune encephalomyelitis is associated with enhanced activity of CNS CD27(low\/-) NK cell subset","volume":"15","author":"Kamyan","year":"2024","journal-title":"Front Immunol"},{"key":"2026072118163980500_vkag148-B148","doi-asserted-by":"crossref","first-page":"5941","DOI":"10.1073\/pnas.0601335103","article-title":"Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2R\u03b1-targeted therapy (daclizumab) in multiple sclerosis","volume":"103","author":"Bielekova","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026072118163980500_vkag148-B149","doi-asserted-by":"crossref","first-page":"781","DOI":"10.4049\/jimmunol.1100789","article-title":"Unexpected role for granzyme K in CD56bright NK cell-mediated immunoregulation of multiple sclerosis","volume":"187","author":"Jiang","year":"2011","journal-title":"J Immunol"},{"key":"2026072118163980500_vkag148-B150","doi-asserted-by":"crossref","first-page":"965","DOI":"10.4049\/jimmunol.1500591","article-title":"CD56brightCD16- NK cells produce adenosine through a CD38-mediated pathway and act as regulatory cells inhibiting autologous CD4+ T cell proliferation","volume":"195","author":"Morandi","year":"2015","journal-title":"J Immunol"},{"key":"2026072118163980500_vkag148-B151","doi-asserted-by":"crossref","first-page":"vkaf347","DOI":"10.1093\/jimmun\/vkaf347","article-title":"IFNgamma\/JAK\/STAT1\/CD38 pathway in SH2D1Bhigh NK cells: implications for inflammation in type 1 diabetes","volume":"215","author":"Chen","year":"2026","journal-title":"J Immunol"},{"key":"2026072118163980500_vkag148-B152","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.3899\/jrheum.101377","article-title":"Natural killer-22 cells in the synovial fluid of patients with rheumatoid arthritis are an innate source of interleukin 22 and tumor necrosis factor-\u03b1","volume":"38","author":"Ren","year":"2011","journal-title":"J Rheumatol"},{"key":"2026072118163980500_vkag148-B153","doi-asserted-by":"crossref","first-page":"13028","DOI":"10.1073\/pnas.1000546107","article-title":"Natural killer cells trigger osteoclastogenesis and bone destruction in arthritis","volume":"107","author":"Soderstrom","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026072118163980500_vkag148-B154","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/s41598-018-37448-z","article-title":"High percentages and activity of synovial fluid NK cells present in patients with advanced stage active rheumatoid arthritis","volume":"9","author":"Yamin","year":"2019","journal-title":"Sci Rep"},{"key":"2026072118163980500_vkag148-B155","doi-asserted-by":"crossref","first-page":"e20191421","DOI":"10.1084\/jem.20191421","article-title":"NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS","volume":"217","author":"Louis","year":"2020","journal-title":". J Exp Med"},{"key":"2026072118163980500_vkag148-B156","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.4049\/jimmunol.0901362","article-title":"Intrahepatic IL-10 maintains NKG2A+Ly49- liver NK cells in a functionally hyporesponsive state","volume":"184","author":"Lassen","year":"2010","journal-title":"J Immunol"},{"key":"2026072118163980500_vkag148-B157","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.cell.2018.07.017","article-title":"Innate lymphoid cells: 10 years on","volume":"174","author":"Vivier","year":"2018","journal-title":"Cell"},{"key":"2026072118163980500_vkag148-B158","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.immuni.2019.06.001","article-title":"Characterization of transcriptional regulatory networks that promote and restrict identities and functions of intestinal innate lymphoid cells","volume":"51","author":"Pokrovskii","year":"2019","journal-title":"Immunity"},{"key":"2026072118163980500_vkag148-B159","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.immuni.2018.05.013","article-title":"Innate lymphoid cells: diversity, plasticity, and unique functions in immunity","volume":"48","author":"Colonna","year":"2018","journal-title":"Immunity"},{"key":"2026072118163980500_vkag148-B160","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.immuni.2015.06.019","article-title":"Interleukin-12 and -23 control plasticity of CD127(+) group 1 and group 3 innate lymphoid cells in the intestinal lamina propria","volume":"43","author":"Bernink","year":"2015","journal-title":"Immunity"},{"key":"2026072118163980500_vkag148-B161","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/ni.3800","article-title":"Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells","volume":"18","author":"Gao","year":"2017","journal-title":"Nat Immunol"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/215\/7\/vkag148\/69695963\/vkag148.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/215\/7\/vkag148\/69695963\/vkag148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:17:26Z","timestamp":1784672246000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/doi\/10.1093\/jimmun\/vkag148\/8739178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":161,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7,10]]}},"URL":"https:\/\/doi.org\/10.1093\/jimmun\/vkag148","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,7]]},"article-number":"vkag148"}}