{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:10:41Z","timestamp":1788793841187,"version":"build-2803163510"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":33,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY036253"],"award-info":[{"award-number":["R01EY036253"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY029426"],"award-info":[{"award-number":["R01EY029426"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY033622"],"award-info":[{"award-number":["R01EY033622"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neurotrophic keratitis (NK) arises when trigeminal sensory dysfunction reduces corneal sensation and compromises epithelial maintenance. Herpes simplex virus type 1 (HSV-1) establishes latency in the trigeminal ganglion (TG) and is a common trigger of acquired NK, yet the host programs that determine whether inflamed ganglia recover or degenerate remain poorly defined. Moreover, experimental models that faithfully capture NK-like neuroimmune pathology are limited. Using a murine ocular HSV-1 infection model, we identify optineurin (OPTN) as a key regulator of trigeminal nerve preservation. Optn\u2212\/\u2212 mice developed severe corneal opacity and rapid, persistent loss of corneal and whisker sensitivity despite comparable corneal viral titers. Droplet-based single-cell RNA sequencing of TGs at 30\u2009days postinfection revealed reduced recovery of peripheral neuronal transcriptomes and coordinated enrichment of chemokine\/NF-\u03baB and Th17\/IL-17 gene signatures across neurons, endothelial cells, and myeloid\/lymphoid populations. Consistent with these transcriptional programs, IL-17 was elevated in Optn\u2212\/\u2212 TGs at 30\u2009days, whereas the cornea and draining lymph nodes did not exhibit increased IL-17 production early after infection. Neuronal staining demonstrated loss of the synaptic marker SNCG without increased neuronal death, implicating IL-17\u2013associated inflammation in neuronal dysfunction rather than acute ablation. Together, these findings identify OPTN as a neuroimmune checkpoint that restrains chronic IL-17\u2013linked ganglionic inflammation to preserve sensory function and suggest that OPTN deficiency provides a tractable experimental model for studying HSV-associated NK.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag161","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T10:52:49Z","timestamp":1783162369000},"source":"Crossref","is-referenced-by-count":0,"title":["Optineurin restrains IL-17\u2013associated neuroinflammation in trigeminal ganglia to preserve sensory function after ocular HSV-1 infection"],"prefix":"10.1093","volume":"215","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9282-5637","authenticated-orcid":false,"given":"Joshua","family":"Ames","sequence":"first","affiliation":[{"name":"University of Illinois Chicago Department of Ophthalmology and Visual Sciences, College of Medicine, , Chicago, IL,","place":["United States"]},{"name":"University of Illinois Chicago Department of Microbiology and Immunology, College of Medicine, , Chicago, IL,","place":["United States"]},{"name":"Department of Immunology, University of Washington , Seattle, WA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Kadam","sequence":"additional","affiliation":[{"name":"University of Illinois Chicago Department of Ophthalmology and Visual Sciences, College of Medicine, , Chicago, IL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8584-2685","authenticated-orcid":false,"given":"Tejabhiram","family":"Yadavalli","sequence":"additional","affiliation":[{"name":"University of Illinois Chicago Department of Ophthalmology and Visual Sciences, College of Medicine, , Chicago, IL,","place":["United 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