{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:10:44Z","timestamp":1788793844781,"version":"build-2803163510"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"He Ruoping National Traditional Chinese Medicine Expert Inheritance Studio Construction Project"},{"name":"Zhejiang Administration of Traditional Chinese Medicine Project","award":["2020ZB134"],"award-info":[{"award-number":["2020ZB134"]}]},{"name":"Seventh Batch of National Academic Experience Inheritance Program for Veteran Traditional Chinese Medicine Experts","award":["[2022]76"],"award-info":[{"award-number":["[2022]76"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Colorectal cancer (CRC) is a leading malignancy with limited treatment options at advanced stages. Interleukin (IL)-17 signaling promotes tumor progression and immune evasion. Kaempferol, a natural flavonol, has anti-inflammatory and antitumor effects, but its role in modulating IL-17 pathways in CRC is unclear. We used an immunocompetent MC38 xenograft model to evaluate kaempferol monotherapy (50\/100\u2009mg\/kg), its combination with a PD-L1 inhibitor, and IL-17 overexpression. Tumor growth, immune infiltration, cytokines, and signaling pathways were assessed using immunohistochemistry, enzyme-linked immunosorbent assay, flow cytometry, and Western blotting. Kaempferol suppressed tumor growth in a dose-dependent manner and showed synergistic effects with PD-L1 inhibitors. It enhanced CD4+ and CD8+ T cell infiltration, reduced IL-17A+ \u03b3\u03b4 T cells, and increased IFN-\u03b3+ \u03b3\u03b4 T cells. Kaempferol also downregulated IL-6, tumor necrosis factor \u03b1, and IL-17A and upregulated IL-2 and interferon \u03b3. Molecular analyses showed inhibition of IL-17A, PD-L1, STAT3, and NF-\u03baB pathway activation. IL-17A overexpression reversed these effects, restoring inflammation, immune suppression, and tumor growth. Kaempferol inhibits CRC progression by targeting IL-17\u2013mediated inflammation and improving antitumor immunity, especially when combined with PD-L1 inhibitors. This study supports kaempferol\u2019s potential as a novel therapeutic strategy for CRC.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag176","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:55:08Z","timestamp":1784760908000},"source":"Crossref","is-referenced-by-count":0,"title":["Kaempferol\u2019s potential in targeting IL-17\u2013mediated inflammatory pathways for colorectal cancer treatment"],"prefix":"10.1093","volume":"215","author":[{"given":"Lu","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Classical Chinese Medicine, The Third Affiliated Hospital of Zhejiang Chinese Medical University , Hangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjie","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Classical Chinese Medicine, The Third Affiliated Hospital of Zhejiang Chinese Medical University , Hangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, The Third Affiliated Hospital of Zhejiang, Chinese Medical University , Hangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"2026090710451412600_vkag176-B1","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1002\/cam4.4488","article-title":"Neurobiology of cancer: definition, historical overview, and clinical implications","volume":"11","author":"Mravec","year":"2022","journal-title":"Cancer Med"},{"key":"2026090710451412600_vkag176-B2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s43162-024-00397-3","article-title":"Synopsis of colorectal cancer: prevalence, symptoms, screening, staging, risk factors, and 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