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Skin injury from ultraviolet (UV) light triggers neutrophil migration to the kidney, which may have implications for nephritis flares in systemic lupus erythematosus. Here, we demonstrate that after skin exposure to UV light, renal neutrophils upregulate proangiogenic transcriptional programs and activate renal endothelial angiogenesis and tissue remodeling processes in healthy kidneys. Ligand-receptor analysis identified Cd177\u2013Pecam1 as a key neutrophil-endothelial interaction. In contrast to healthy control mice, skin exposure to UV light stimulated the expression of Tgf\u03b2 and Wnt signaling pathways in lupus-prone MRL\/lpr mice. This tissue remodeling response was neutrophil dependent. Spatial transcriptomic analysis of lupus nephritis kidneys revealed that tissue remodeling and profibrotic pathways are highly expressed in neutrophil-rich areas. Neutrophil intrarenal levels were higher in the kidneys of lupus nephritis patients with active skin disease, compared with those without skin involvement at the time of the nephritis flare. Moreover, urinary neutrophils were increased in systemic lupus erythematosus patients with active skin disease, including sun-associated skin rash, even in the absence of lupus nephritis. These results support a model in which UV-triggered skin injury activates a neutrophil-mediated skin-kidney axis that promotes differential tissue remodeling pathways in healthy compared with lupus-prone kidneys.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag178","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:03:23Z","timestamp":1788282203000},"source":"Crossref","is-referenced-by-count":0,"title":["A skin-kidney neutrophil axis links ultraviolet exposure to renal angiogenesis and tissue remodeling in healthy and lupus kidneys"],"prefix":"10.1093","volume":"215","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2277-5205","authenticated-orcid":false,"given":"Angelique","family":"Cortez","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth , Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay K","family":"Mendyka","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth , Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alecia","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth , Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua J","family":"Skydel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dartmouth Hitchcock Medical Center , Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lais","family":"Osmani","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dartmouth Hitchcock Medical Center , Lebanon, NH,","place":["United 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School of Medicine at Dartmouth , Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred W","family":"Kolling","sequence":"additional","affiliation":[{"name":"Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth , Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen M","family":"Wilkins","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth , Lebanon, NH,","place":["United States"]},{"name":"Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth , Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia F","family":"Brooker","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dartmouth Hitchcock Medical Center , Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinaza","family":"Nnam","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Geisel School of Medicine at Dartmouth , Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Pettus","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Geisel School of Medicine at Dartmouth , Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Celia","sequence":"additional","affiliation":[{"name":"Department of Medicine, Johns Hopkins University , Baltimore, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F C","family":"Rigby","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dartmouth Hitchcock Medical Center , Lebanon, NH,","place":["United 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