{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:10:42Z","timestamp":1788793842364,"version":"build-2803163510"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Institutes of Health\/National Institute of Allergy and Infectious Diseases","award":["R56AI158869"],"award-info":[{"award-number":["R56AI158869"]}]},{"name":"National Institutes of Health\/National Institute of Allergy and Infectious Diseases","award":["R21AI176326"],"award-info":[{"award-number":["R21AI176326"]}]},{"name":"National Institutes of Health\/National Institute of Allergy and Infectious Diseases","award":["R01AI196441"],"award-info":[{"award-number":["R01AI196441"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hematopoietic cell transplantation (HCT) is a curative immunotherapy for hematologic malignancies such as acute myeloid leukemia, primarily through graft-versus-tumor (GVT) effects mediated by donor T cells. However, up to 60% of recipients develop graft-versus-host disease (GVHD), with intestinal involvement being a major contributor to morbidity and mortality. While CD8 T cells drive GVT, CD4 T helper (Th) cells are largely the key mediators of intestinal GVHD. Although IFN-\u03b3\u2013producing Th1 cells have been implicated in this process, recent evidence suggests a more complex role for Th cell subtypes. In our study, we identify the transcription factor GATA3, often associated with Th2 function, as a key regulator of Th cell proliferation, gut persistence, and cytokine production. Specifically, donor cell GATA3 was required for the early production of gut\u2011damaging granzyme A by intestinal Th cells and sustained granulocyte-macrophage colony-stimulating factor (GM\u2011CSF) production at later phases of the intestinal GVHD response. GATA3\u2011mediated maintenance of GM\u2011CSF expression during these later stages of disease was associated with increased intestinal eosinophil recruitment and activation, features that have been linked to GVHD severity in humans. Collectively, our findings demonstrate that GATA3\u2011expressing Th cells contribute to intestinal GVHD pathogenesis by sustaining GM-CSF\u2013driven inflammatory circuits and promoting chronic eosinophilia. Targeting GATA3, or its downstream effector pathways, may therefore represent a novel therapeutic strategy to attenuate intestinal GVHD while preserving the overall efficacy of HCT.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag190","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T22:28:22Z","timestamp":1784932102000},"source":"Crossref","is-referenced-by-count":0,"title":["Donor cell GATA3 is critical for gut pathogenic T cell effector function and intestinal eosinophilia after hematopoietic cell transplantation"],"prefix":"10.1093","volume":"215","author":[{"given":"Franklin J","family":"Yeo","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Purdue University , West Lafayette, IN,","place":["United States"]},{"name":"Purdue Institute of Cancer Research, Purdue University , West Lafayette, IN,","place":["United 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Biological Sciences, Purdue University , West Lafayette, IN,","place":["United States"]},{"name":"Purdue Institute of Cancer Research, Purdue University , West Lafayette, IN,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Khandelwal","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Medical Research Hospital, Cincinnati, OH, United States Division of Bone Marrow Transplantation and Immune Deficiency,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L","family":"Rust","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Purdue University , West Lafayette, IN,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7436-9412","authenticated-orcid":false,"given":"Brittany","family":"Allen-Petersen","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Purdue 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