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In this study, we identify dual specificity phosphatase 2 (DUSP2) as a key epigenetic modulator of effector CD8+ T-cell state, by elucidating inhibition of BAF-mediated chromatin opening by DUSP2. Induced downregulation of DUSP2 in human CD8+ T cells enhances cytotoxicity and effector phenotypes by increasing chromatin accessibility through upregulation of BAF subunits, such as SMARCA4, and permitting binding of ETS1 to BAF subunit gene loci and those essential for effector programs. These findings uncover a previously unrecognized role of DUSP2 in the management of the chromatin landscape in effector CD8+ T cells and the epigenetic fine-tuning of their functionality, highlighting DUSP2 as a promising therapeutic target for T cell\u2013based immunotherapy.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag202","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:12:31Z","timestamp":1785301951000},"source":"Crossref","is-referenced-by-count":0,"title":["CD8+ T-cell effector programming is epigenetically regulated by DUSP2 through BAF complex\u2013driven chromatin remodeling"],"prefix":"10.1093","volume":"215","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9031-2240","authenticated-orcid":false,"given":"Emilia R","family":"Dellacecca","sequence":"first","affiliation":[{"name":"Mayo Clinic Graduate School of Biomedical Sciences Department of Immunology, , Rochester, MN,","place":["United States"]},{"name":"Department of Immunology, Mayo Clinic , Rochester, MN,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob B","family":"Hirdler","sequence":"additional","affiliation":[{"name":"Mayo Clinic Graduate School of Biomedical Sciences Department of Immunology, , Rochester, MN,","place":["United States"]},{"name":"Department of Immunology, Mayo Clinic , Rochester, MN,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney","family":"Barham","sequence":"additional","affiliation":[{"name":"Mayo Clinic Graduate School of Biomedical Sciences Department of Immunology, , Rochester, MN,","place":["United States"]},{"name":"Department of Immunology, Mayo Clinic , Rochester, MN,","place":["United States"]},{"name":"Division of Cardiology, Department of Medicine, Vanderbilt University Medical Center , Nashville, TN,","place":["United 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