{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:10:45Z","timestamp":1788793845726,"version":"build-2803163510"},"reference-count":99,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI-57596"],"award-info":[{"award-number":["AI-57596"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI-107811"],"award-info":[{"award-number":["AI-107811"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Our laboratory has previously described a mouse model (CD40L\u03945) that produces 60% of wild-type CD40L due to a targeted deletion in an RNA binding site within the CD40L message. The CD40L\u03945 mutation, which destabilizes CD40L mRNA during T-cell activation, causes disrupted germinal center (GC) formation, leading to reduced levels of memory B cells and switched antibodies. In this study, we used our model of limited CD40L expression to investigate its effect on systemic lupus erythematosus (SLE, or lupus) using 2 different mouse models of SLE. The first model used the hydrocarbon oil pristane to induce lupus-like symptoms over a 6-month period, and the second utilized a chronic graft-versus-host disease (bm12-cGVHD) that resembles lupus and allowed us to monitor the early events in disease development. Importantly, we found that in both systems, female mice expressing the CD40L\u03945 mutation showed a consistent increase in elevated antibody-secreting cells and autoantibody titers. In addition, pristane-induced lupus female CD40L\u03945 mice had higher levels of immunocomplex deposition in the kidney compared to all other cohorts. Increases in autoantibodies and GC cells in female CD40L\u03945 versus wild-type recipient mice were also evident in the bm12-cGVHD model. Additionally, CD4+ T cells from female CD40L\u03945 recipient mice were skewed toward a\u00a0Th2 phenotype and expressed a distinct cytokine expression pattern upon activation of dendritic cells. Overall, our results support a nuanced role for optimal CD40L expression in lupus and suggest a sex-determined threshold of CD40L\u2013CD40 signaling that is critical at the very early steps of disease progression.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag205","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:55:56Z","timestamp":1785394556000},"source":"Crossref","is-referenced-by-count":0,"title":["Lowering CD40L expression in murine lupus results in an increase in disease indicators in female but not male B6 mice"],"prefix":"10.1093","volume":"215","author":[{"given":"Diego","family":"Prado De Maio","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Neuroscience, Rutgers University , New Brunswick, NJ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Tetteh","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neuroscience, Rutgers University , New Brunswick, NJ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Ayers","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neuroscience, Rutgers University , New Brunswick, NJ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"St. Martin","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neuroscience, Rutgers University , New Brunswick, NJ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neuroscience, Rutgers University , New Brunswick, NJ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5425-9427","authenticated-orcid":false,"given":"Lori R","family":"Covey","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neuroscience, Rutgers University , New Brunswick, NJ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"2026090710450059700_vkag205-B1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1600-065X.2009.00782.x","article-title":"Molecular mechanism and function of CD40\/CD40L engagement in the immune system","volume":"229","author":"Elgueta","year":"2009","journal-title":"Immunol Rev"},{"key":"2026090710450059700_vkag205-B2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev.immunol.22.012703.104533","article-title":"CD40\/CD154 interactions at the interface of tolerance and immunity","volume":"22","author":"Quezada","year":"2004","journal-title":"Annu Rev Immunol"},{"key":"2026090710450059700_vkag205-B3","doi-asserted-by":"crossref","first-page":"e150","DOI":"10.1371\/journal.pbio.0030150","article-title":"Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells","volume":"3","author":"Okada","year":"2005","journal-title":"PLoS Biol"},{"key":"2026090710450059700_vkag205-B4","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1126\/science.281.5373.96","article-title":"Visualization of specific B and T lymphocyte interactions in the lymph node","volume":"281","author":"Garside","year":"1998","journal-title":"Science"},{"key":"2026090710450059700_vkag205-B5","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1084\/jem.178.5.1567","article-title":"In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39","volume":"178","author":"Foy","year":"1993","journal-title":"J Exp Med"},{"key":"2026090710450059700_vkag205-B6","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1084\/jem.178.5.1555","article-title":"In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate T-B cell interactions","volume":"178","author":"Eertwegh","year":"1993","journal-title":"J Exp Med"},{"key":"2026090710450059700_vkag205-B7","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1172\/JCI0214110","article-title":"Short-circuiting long-lived humoral immunity by the heightened engagement of CD40","volume":"109","author":"Erickson","year":"2002","journal-title":"J Clin Invest"},{"key":"2026090710450059700_vkag205-B8","doi-asserted-by":"crossref","first-page":"220","DOI":"10.4049\/jimmunol.0901689","article-title":"Constitutive CD40L expression on B cells prematurely terminates germinal center response and leads to augmented plasma cell production in T cell areas","volume":"185","author":"Bolduc","year":"2010","journal-title":"J Immunol"},{"key":"2026090710450059700_vkag205-B9","article-title":"Germinal center B cell development has distinctly regulated stages completed by disengagement from T cell help","volume":"6","author":"Zhang","year":"2017","journal-title":"Elife"},{"key":"2026090710450059700_vkag205-B10","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1084\/jem.192.11.1545","article-title":"Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production","volume":"192","author":"Breitfeld","year":"2000","journal-title":"J Exp Med"},{"key":"2026090710450059700_vkag205-B11","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1084\/jem.192.11.1553","article-title":"CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function","volume":"192","author":"Schaerli","year":"2000","journal-title":"J Exp Med"},{"key":"2026090710450059700_vkag205-B12","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1084\/jem.193.12.1373","article-title":"Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells","volume":"193","author":"Kim","year":"2001","journal-title":"J Exp Med"},{"key":"2026090710450059700_vkag205-B13","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.immuni.2011.03.023","article-title":"ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6","volume":"34","author":"Choi","year":"2011","journal-title":"Immunity"},{"key":"2026090710450059700_vkag205-B14","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.coi.2017.03.007","article-title":"Deconstructing the germinal center, one cell at a time","volume":"45","author":"Dufaud","year":"2017","journal-title":"Curr Opin Immunol"},{"key":"2026090710450059700_vkag205-B15","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.immuni.2014.10.004","article-title":"T follicular helper cell differentiation, function, and roles in disease","volume":"41","author":"Crotty","year":"2014","journal-title":"Immunity"},{"key":"2026090710450059700_vkag205-B16","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.immuni.2016.09.001","article-title":"Germinal center B cell dynamics","volume":"45","author":"Mesin","year":"2016","journal-title":"Immunity"},{"key":"2026090710450059700_vkag205-B17","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.cell.2010.10.032","article-title":"Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter","volume":"143","author":"Victora","year":"2010","journal-title":"Cell"},{"key":"2026090710450059700_vkag205-B18","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nature13300","article-title":"Clonal selection in the germinal centre by regulated proliferation and hypermutation","volume":"509","author":"Gitlin","year":"2014","journal-title":"Nature"},{"key":"2026090710450059700_vkag205-B19","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1084\/jem.184.2.747","article-title":"Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation","volume":"184","author":"Cella","year":"1996","journal-title":"J Exp Med"},{"key":"2026090710450059700_vkag205-B20","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/j.1365-2567.2006.02329.x","article-title":"Distinct regulation of CD40-mediated interleukin-6 and interleukin-12 productions via mitogen-activated protein kinase and nuclear factor kappaB-inducing kinase in mature dendritic cells","volume":"117","author":"Yanagawa","year":"2006","journal-title":"Immunology"},{"key":"2026090710450059700_vkag205-B21","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0167-5699(96)80606-2","article-title":"The expanding universe of T-cell subsets: Th1, Th2 and more","volume":"17","author":"Mosmann","year":"1996","journal-title":"Immunol Today"},{"key":"2026090710450059700_vkag205-B22","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S1074-7613(00)80533-6","article-title":"Cytokines induce the development of functionally heterogeneous T helper cell subsets","volume":"8","author":"O\u2019Garra","year":"1998","journal-title":"Immunity"},{"key":"2026090710450059700_vkag205-B23","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/s41423-020-0465-0","article-title":"Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses","volume":"17","author":"Hilligan","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"2026090710450059700_vkag205-B24","doi-asserted-by":"crossref","first-page":"4478","DOI":"10.4049\/jimmunol.165.8.4478","article-title":"Identification of a complex that binds to the CD154 3\u2032 untranslated region: implications for a role in message stability during T cell activation","volume":"165","author":"Barnhart","year":"2000","journal-title":"J Immunol"},{"key":"2026090710450059700_vkag205-B25","doi-asserted-by":"crossref","first-page":"979","DOI":"10.4049\/jimmunol.170.2.979","article-title":"A complex containing polypyrimidine tract-binding protein is involved in regulating the stability of CD40 ligand (CD154) mRNA","volume":"170","author":"Kosinski","year":"2003","journal-title":"J Immunol"},{"key":"2026090710450059700_vkag205-B26","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.4049\/jimmunol.2001074","article-title":"A posttranscriptional pathway of CD40 ligand mRNA stability is required for the development of an optimal humoral immune response","volume":"206","author":"Narayanan","year":"2021","journal-title":"J Immunol"},{"key":"2026090710450059700_vkag205-B27","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1084\/jem.20081886","article-title":"Follicular helper T cells are required for systemic autoimmunity","volume":"206","author":"Linterman","year":"2009","journal-title":"J Exp Med"},{"key":"2026090710450059700_vkag205-B28","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nri2637","article-title":"Dysregulation of germinal centres in autoimmune disease","volume":"9","author":"Vinuesa","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"2026090710450059700_vkag205-B29","doi-asserted-by":"crossref","first-page":"10717","DOI":"10.1073\/pnas.0601539103","article-title":"Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival","volume":"103","author":"Lesley","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090710450059700_vkag205-B30","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev-immunol-041015-055605","article-title":"Follicular helper T cells","volume":"34","author":"Vinuesa","year":"2016","journal-title":"Annu Rev Immunol"},{"key":"2026090710450059700_vkag205-B31","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S1074-7613(02)00298-4","article-title":"The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cells","volume":"16","author":"Seo","year":"2002","journal-title":"Immunity"},{"key":"2026090710450059700_vkag205-B32","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.immuni.2018.08.015","article-title":"Distinct effector B cells induced by unregulated Toll-like receptor 7 contribute to pathogenic responses in systemic lupus erythematosus","volume":"49","author":"Jenks","year":"2018","journal-title":"Immunity"},{"key":"2026090710450059700_vkag205-B33","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1126\/science.1073924","article-title":"Evolution of autoantibody responses via somatic hypermutation outside of germinal centers","volume":"297","author":"William","year":"2002","journal-title":"Science"},{"key":"2026090710450059700_vkag205-B34","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/imr.12741","article-title":"Extrafollicular responses in humans and SLE","volume":"288","author":"Jenks","year":"2019","journal-title":"Immunol Rev"},{"key":"2026090710450059700_vkag205-B35","doi-asserted-by":"crossref","first-page":"1021370","DOI":"10.3389\/fimmu.2022.1021370","article-title":"The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus","volume":"13","author":"Voss","year":"2022","journal-title":"Front Immunol"},{"key":"2026090710450059700_vkag205-B36","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1172\/JCI118855","article-title":"Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes","volume":"98","author":"Koshy","year":"1996","journal-title":"J Clin Invest"},{"key":"2026090710450059700_vkag205-B37","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1172\/JCI118643","article-title":"Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production","volume":"97","author":"Desai-Mehta","year":"1996","journal-title":"J Clin Invest"},{"key":"2026090710450059700_vkag205-B38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4049\/jimmunol.168.1.9","article-title":"Cutting edge: ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease","volume":"168","author":"Higuchi","year":"2002","journal-title":"J Immunol"},{"key":"2026090710450059700_vkag205-B39","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1191\/0961203302lu211oa","article-title":"CD40L overexpression on T cells and monocytes from patients with systemic lupus erythematosus is resistant to calcineurin inhibition","volume":"11","author":"Katsiari","year":"2002","journal-title":"Lupus"},{"key":"2026090710450059700_vkag205-B40","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.smim.2009.05.012","article-title":"CD40 and autoimmunity: the dark side of a great activator","volume":"21","author":"Peters","year":"2009","journal-title":"Semin Immunol"},{"key":"2026090710450059700_vkag205-B41","doi-asserted-by":"crossref","first-page":"102668","DOI":"10.1016\/j.autrev.2020.102668","article-title":"Phoenix from the flames: rediscovering the role of the CD40-CD40L pathway in systemic lupus erythematosus and lupus nephritis","volume":"19","author":"Ramanujam","year":"2020","journal-title":"Autoimmun Rev"},{"key":"2026090710450059700_vkag205-B42","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.4049\/jimmunol.154.3.1470","article-title":"Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis","volume":"154","author":"Mohan","year":"1995","journal-title":"J Immunol"},{"key":"2026090710450059700_vkag205-B43","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF01540954","article-title":"Therapeutic potential for blockade of the CD40 ligand, gp39","volume":"16","author":"Buhlmann","year":"1996","journal-title":"J Clin Immunol"},{"key":"2026090710450059700_vkag205-B44","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.rdc.2005.09.007","article-title":"New therapies for systemic lupus erythematosus: cellular targets","volume":"32","author":"Looney","year":"2006","journal-title":"Rheum Dis Clin North Am"},{"key":"2026090710450059700_vkag205-B45","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1191\/0961203304lu1032oa","article-title":"Lessons learned from anti-CD40L treatment in systemic lupus erythematosus patients","volume":"13","author":"Sidiropoulos","year":"2004","journal-title":"Lupus"},{"key":"2026090710450059700_vkag205-B46","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1126\/science.ade6949","article-title":"Switching off autoimmunity","volume":"385","author":"Laman","year":"2024","journal-title":"Science"},{"key":"2026090710450059700_vkag205-B47","doi-asserted-by":"crossref","first-page":"5397","DOI":"10.1093\/rheumatology\/keab381","article-title":"Phase 2, randomized, placebo-controlled trial of dapirolizumab pegol in patients with moderate-to-severe active systemic lupus erythematosus","volume":"60","author":"Furie","year":"2021","journal-title":"Rheumatology (Oxford)"},{"key":"2026090710450059700_vkag205-B48","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.4049\/jimmunol.1303239","article-title":"Engineering of a novel anti-CD40L domain antibody for treatment of autoimmune diseases","volume":"192","author":"Xie","year":"2014","journal-title":"J Immunol"},{"key":"2026090710450059700_vkag205-B49","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.4049\/jimmunol.175.7.4777","article-title":"Induction of apoptosis by the hydrocarbon oil pristane: implications for pristane-induced lupus","volume":"175","author":"Calvani","year":"2005","journal-title":"J Immunol"},{"key":"2026090710450059700_vkag205-B50","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1186\/s13075-015-0886-9","article-title":"Maintenance of autoantibody production in pristane-induced murine lupus","volume":"17","author":"Han","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"2026090710450059700_vkag205-B51","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.it.2009.06.003","article-title":"Induction of autoimmunity by pristane and other naturally occurring hydrocarbons","volume":"30","author":"Reeves","year":"2009","journal-title":"Trends Immunol"},{"key":"2026090710450059700_vkag205-B52","first-page":"e53319","article-title":"The bm12 inducible model of systemic lupus erythematosus (SLE) in C57BL\/6 mice","volume":"105","author":"Klarquist","year":"2015","journal-title":"J Vis Exp"},{"key":"2026090710450059700_vkag205-B53","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1084\/jem.171.2.503","article-title":"Autoantibodies in chronic graft versus host result from cognate T-B interactions","volume":"171","author":"Morris","year":"1990","journal-title":"J Exp Med"},{"key":"2026090710450059700_vkag205-B54","first-page":"271694","article-title":"Murine models of systemic lupus erythematosus","volume":"2011","author":"Perry","year":"2011","journal-title":"J Biomed Biotechnol"},{"key":"2026090710450059700_vkag205-B55","doi-asserted-by":"crossref","first-page":"e000199","DOI":"10.1136\/lupus-2016-000199","article-title":"Mouse models of lupus: what they tell us and what they don\u2019t","volume":"5","author":"Richard","year":"2018","journal-title":"Lupus Sci Med"},{"key":"2026090710450059700_vkag205-B56","doi-asserted-by":"crossref","first-page":"929","DOI":"10.3389\/fphar.2020.00929","article-title":"Coptisine alleviates pristane-induced lupus-like disease and associated kidney and cardiovascular complications in mice","volume":"11","author":"Yan","year":"2020","journal-title":"Front Pharmacol"},{"key":"2026090710450059700_vkag205-B57","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1038\/s41598-018-21337-6","article-title":"CD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven and TRPM2-dependent mechanism","volume":"8","author":"Garc\u00eda-Rodr\u00edguez","year":"2018","journal-title":"Sci Rep"},{"key":"2026090710450059700_vkag205-B58","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.4049\/jimmunol.2200563","article-title":"Upregulated expression of the IL-9 receptor on TRAF3-deficient B lymphocytes confers Ig isotype switching responsiveness to IL-9 in the presence of antigen receptor engagement and IL-4","volume":"210","author":"Gokhale","year":"2023","journal-title":"J Immunol"},{"key":"2026090710450059700_vkag205-B59","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1186\/s12967-024-05368-4","article-title":"Factor of time in dendritic cell (DC) maturation: short-term activation of DCs significantly improves type 1 cytokine production and T cell responses","volume":"22","author":"Pozenel","year":"2024","journal-title":"J Transl Med"},{"key":"2026090710450059700_vkag205-B60","doi-asserted-by":"crossref","first-page":"1601079","DOI":"10.1155\/2018\/1601079","article-title":"Conventional DCs from male and female lupus-prone B6.NZM Sle1\/Sle2\/Sle3 mice express an IFN signature and have a higher immunometabolism that are enhanced by estrogen","volume":"2018","author":"Lee","year":"2018","journal-title":"J Immunol Res"},{"key":"2026090710450059700_vkag205-B61","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.4049\/jimmunol.1701179","article-title":"Relative contributions of B cells and dendritic cells from lupus-prone mice to CD4(+) T cell polarization","volume":"200","author":"Choi","year":"2018","journal-title":"J Immunol"},{"key":"2026090710450059700_vkag205-B62","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.intimp.2016.09.001","article-title":"Estradiol enhances capacity of TLR-matured splenic dendritic cells to polarize CD4+ lymphocytes into IL-17\/GM-CSF-producing cells in vitro","volume":"40","author":"Stojic-Vukanic","year":"2016","journal-title":"Int Immunopharmacol"},{"key":"2026090710450059700_vkag205-B63","doi-asserted-by":"crossref","first-page":"e8412","DOI":"10.1371\/journal.pone.0008412","article-title":"17beta-estradiol enhances the response of plasmacytoid dendritic cell to CpG","volume":"4","author":"Li","year":"2009","journal-title":"PLoS One"},{"key":"2026090710450059700_vkag205-B64","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1046\/j.1365-2249.2000.01276.x","article-title":"Widespread susceptibility among inbred mouse strains to the induction of lupus autoantibodies by pristane","volume":"121","author":"Satoh","year":"2000","journal-title":"Clin Exp Immunol"},{"key":"2026090710450059700_vkag205-B65","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1007\/s10067-017-3811-6","article-title":"Pristane-induced lupus: considerations on this experimental model","volume":"36","author":"Freitas","year":"2017","journal-title":"Clin Rheumatol"},{"key":"2026090710450059700_vkag205-B66","doi-asserted-by":"crossref","first-page":"116775","DOI":"10.1016\/j.celrep.2025.116775","article-title":"IgG2c subclass dominance drives fatal lupus-like nephritis via Fc\u03b3R and complement activation","volume":"45","author":"Luan","year":"2026","journal-title":"Cell Rep"},{"key":"2026090710450059700_vkag205-B67","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0090-1229(90)90040-W","article-title":"Experimental induction of systemic lupus erythematosus by recognition of foreign Ia","volume":"57","author":"Morris","year":"1990","journal-title":"Clin Immunol Immunopathol"},{"key":"2026090710450059700_vkag205-B68","doi-asserted-by":"crossref","first-page":"713697","DOI":"10.3389\/fimmu.2021.713697","article-title":"CD38 deficiency ameliorates chronic graft-versus-host disease murine lupus via a B-cell-dependent mechanism","volume":"12","author":"Mart\u00ednez-Blanco","year":"2021","journal-title":"Front Immunol"},{"key":"2026090710450059700_vkag205-B69","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jaut.2012.05.017","article-title":"T cells, murine chronic graft-versus-host disease and autoimmunity","volume":"39","author":"Eisenberg","year":"2012","journal-title":"J Autoimmun"},{"key":"2026090710450059700_vkag205-B70","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.clim.2016.06.009","article-title":"Slamf6 negatively regulates autoimmunity","volume":"173","author":"Wang","year":"2016","journal-title":"Clin Immunol"},{"key":"2026090710450059700_vkag205-B71","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1080\/08916934.2019.1693545","article-title":"Th1, Th2, and Th17 cytokines in systemic lupus erythematosus","volume":"53","author":"Muhammad Yusoff","year":"2020","journal-title":"Autoimmunity"},{"key":"2026090710450059700_vkag205-B72","doi-asserted-by":"crossref","first-page":"646","DOI":"10.5603\/FHC.2011.0088","article-title":"Imbalance between Th17 and regulatory T-cells in systemic lupus erythematosus","volume":"49","author":"Kleczynska","year":"2011","journal-title":"Folia Histochem Cytobiol"},{"key":"2026090710450059700_vkag205-B73","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cyto.2014.12.027","article-title":"Th1\/Th2\/Th17\/Treg cytokine imbalance in systemic lupus erythematosus (SLE) patients: correlation with disease activity","volume":"72","author":"Talaat","year":"2015","journal-title":"Cytokine"},{"key":"2026090710450059700_vkag205-B74","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1191\/096120300678828703","article-title":"Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus","volume":"9","author":"Wong","year":"2000","journal-title":"Lupus"},{"key":"2026090710450059700_vkag205-B75","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.4049\/jimmunol.1800721","article-title":"Cutting edge: quantitative determination of CD40L threshold for IL-12 and IL-23 production from dendritic cells","volume":"201","author":"Abdi","year":"2018","journal-title":"J Immunol"},{"key":"2026090710450059700_vkag205-B76","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0161-5890(02)00210-9","article-title":"The two faces of IL-6 on Th1\/Th2 differentiation","volume":"39","author":"Diehl","year":"2002","journal-title":"Mol Immunol"},{"key":"2026090710450059700_vkag205-B77","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1177\/1535370218824547","article-title":"IL-12 and IL-23\/Th17 axis in systemic lupus erythematosus","volume":"244","author":"Larosa","year":"2019","journal-title":"Exp Biol Med (Maywood)"},{"key":"2026090710450059700_vkag205-B78","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/eji.201948134","article-title":"The IL-12-STAT4 axis in the pathogenesis of human systemic lupus erythematosus","volume":"50","author":"Ueno","year":"2020","journal-title":"Eur J Immunol"},{"key":"2026090710450059700_vkag205-B79","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1210\/edrv.20.3.0370","article-title":"Estrogen receptor null mice: what have we learned and where will they lead us?","volume":"20","author":"Couse","year":"1999","journal-title":"Endocr Rev"},{"key":"2026090710450059700_vkag205-B80","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1146\/annurev-immunol-101819-025146","article-title":"Dendritic cell regulation of T helper cells","volume":"39","author":"Yin","year":"2021","journal-title":"Annu Rev Immunol"},{"key":"2026090710450059700_vkag205-B81","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/eji.201545760","article-title":"T follicular helper (Tfh) cells in lupus: activation and involvement in SLE pathogenesis","volume":"46","author":"Blanco","year":"2016","journal-title":"Eur J Immunol"},{"key":"2026090710450059700_vkag205-B82","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0952-7915(00)00256-9","article-title":"Human genetic defects in class-switch recombination (hyper-IgM syndromes)","volume":"13","author":"Durandy","year":"2001","journal-title":"Curr Opin Immunol"},{"key":"2026090710450059700_vkag205-B83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clim.2014.05.004","article-title":"Emerging role of IL-17 and Th17 cells in systemic lupus erythematosus","volume":"154","author":"Martin","year":"2014","journal-title":"Clin Immunol"},{"key":"2026090710450059700_vkag205-B84","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1046\/j.1523-1755.2001.00045.x","article-title":"Interferon-gamma is required for lupus nephritis in mice treated with the hydrocarbon oil pristane","volume":"60","author":"Richards","year":"2001","journal-title":"Kidney Int"},{"key":"2026090710450059700_vkag205-B85","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.immuni.2018.10.012","article-title":"The transcription factor Ets1 suppresses T follicular helper type 2 cell differentiation to halt the onset of systemic lupus erythematosus","volume":"49","author":"Kim","year":"2018","journal-title":"Immunity"},{"key":"2026090710450059700_vkag205-B86","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1093\/intimm\/dxh295","article-title":"Ets-1 deficiency leads to altered B cell differentiation, hyperresponsiveness to TLR9 and autoimmune disease","volume":"17","author":"Wang","year":"2005","journal-title":"Int Immunol"},{"key":"2026090710450059700_vkag205-B87","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1016\/j.celrep.2019.10.069","article-title":"IL-12 blocks Tfh cell differentiation during salmonella infection, thereby contributing to germinal center suppression","volume":"29","author":"Elsner","year":"2019","journal-title":"Cell Rep"},{"key":"2026090710450059700_vkag205-B88","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.it.2023.04.004","article-title":"A model of Th2 differentiation based on polarizing cytokine repression","volume":"44","author":"Le\u00f3n","year":"2023","journal-title":"Trends Immunol"},{"key":"2026090710450059700_vkag205-B89","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/ni0901-777","article-title":"Sex differences in autoimmune disease","volume":"2","author":"Whitacre","year":"2001","journal-title":"Nat Immunol"},{"key":"2026090710450059700_vkag205-B90","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/0022-4731(83)90131-0","article-title":"Specific estrogen binding sites in human lymphoid cells and thymic cells","volume":"18","author":"Danel","year":"1983","journal-title":"J Steroid Biochem"},{"key":"2026090710450059700_vkag205-B91","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.4049\/jimmunol.1203312","article-title":"Estradiol promotes functional responses in inflammatory and steady-state dendritic cells through differential requirement for activation function-1 of estrogen receptor alpha","volume":"190","author":"Seillet","year":"2013","journal-title":"J Immunol"},{"key":"2026090710450059700_vkag205-B92","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.4049\/jimmunol.172.3.1426","article-title":"Estrogen preferentially promotes the differentiation of CD11c+ CD11b (intermediate) dendritic cells from bone marrow precursors","volume":"172","author":"Paharkova-Vatchkova","year":"2004","journal-title":"J Immunol"},{"key":"2026090710450059700_vkag205-B93","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.4049\/jimmunol.180.6.3661","article-title":"Estrogen receptor alpha, but not beta, is required for optimal dendritic cell differentiation and [corrected] CD40-induced cytokine production","volume":"180","author":"Douin-Echinard","year":"2008","journal-title":"J Immunol"},{"key":"2026090710450059700_vkag205-B94","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cellimm.2007.10.008","article-title":"Regulation of dendritic cell differentiation and function by estrogen receptor ligands","volume":"252","author":"Kovats","year":"2008","journal-title":"Cell Immunol"},{"key":"2026090710450059700_vkag205-B95","doi-asserted-by":"crossref","first-page":"5327","DOI":"10.4049\/jimmunol.1501684","article-title":"Sex differences in plasmacytoid dendritic cell levels of IRF5 drive higher IFN-alpha production in women","volume":"195","author":"Griesbeck","year":"2015","journal-title":"J Immunol"},{"key":"2026090710450059700_vkag205-B96","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1080\/08820130801973328","article-title":"Estrogen modulates bone marrow-derived DCs in SLE murine model-(NZB x NZW) F1 female mice","volume":"37","author":"Jiang","year":"2008","journal-title":"Immunol Invest"},{"key":"2026090710450059700_vkag205-B97","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.4049\/jimmunol.180.3.1423","article-title":"17beta-estradiol alters the activity of conventional and IFN-producing killer dendritic cells","volume":"180","author":"Siracusa","year":"2008","journal-title":"J Immunol"},{"key":"2026090710450059700_vkag205-B98","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1128\/IAI.00008-06","article-title":"Involvement of gonadal steroids and gamma interferon in sex differences in response to blood-stage malaria infection","volume":"74","author":"Cernetich","year":"2006","journal-title":"Infect Immun"},{"key":"2026090710450059700_vkag205-B99","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/s41590-024-01858-1","article-title":"IL-12 induces a B cell-intrinsic IL-12\/IFN\u03b3 feed-forward loop promoting extrafollicular B cell responses","volume":"25","author":"Elsner","year":"2024","journal-title":"Nat Immunol"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/215\/7\/vkag205\/70381842\/vkag205.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/215\/7\/vkag205\/70381842\/vkag205.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:45:22Z","timestamp":1788792322000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/doi\/10.1093\/jimmun\/vkag205\/8747191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":99,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7,10]]}},"URL":"https:\/\/doi.org\/10.1093\/jimmun\/vkag205","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,7]]},"article-number":"vkag205"}}