{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T02:44:41Z","timestamp":1786157081936,"version":"build-2736575974"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Institutes of Health\/National Institute of Allergy and Infectious Diseases","award":["R21AI176640"],"award-info":[{"award-number":["R21AI176640"]}]},{"name":"National Institutes of Health\/National Institute of Allergy and Infectious Diseases","award":["R01AI186995"],"award-info":[{"award-number":["R01AI186995"]}]},{"name":"National Institutes of Health\/National Institute of Allergy and Infectious Diseases","award":["P01AI089618"],"award-info":[{"award-number":["P01AI089618"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Golden hamster (Mesocricetus auratus) and ferret (Mustela putorius furo) are important animal models in studies of human infectious disease. They are used widely to investigate pathogen-spreading mechanisms and host immunology to evaluate the safety and efficacy of small molecules, biologic drugs and vaccines. To this end, immunoglobulin A (IgA) and its Fc\u03b1 receptor (Fc\u03b1R) play critical roles in humans but are not well characterized in these 2 species. Golden hamster and ferret IgA and Fc\u03b1R were recombinantly expressed, purified, and characterized for N-linked glycosylation site occupancy and binding affinity. Based on sequence and structural alignments, hamster IgA showed greater similarity to human IgA than did ferret, and hinge domains in both small animal models suggested greater structural homology to human IgA2 than IgA1. Despite considerable sequence divergence in both immunoglobulins and receptors, and the lack of binding between ferret Fc\u03b1R and ferret IgA, human IgA bound to both hamster and ferret Fc\u03b1R with high affinity. Further, differences in dissociation rates were dependent on test format, suggesting that the 2:1 stoichiometry of human Fc\u03b1R: IgA is recapitulated in these animals. Overall, this work suggests the suitability of these animals to model protection or pathology driven by interactions between human IgA and host Fc\u03b1R and will aid in critical and confident interpretation of infection and immunization studies in each species.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag218","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T02:22:41Z","timestamp":1786155761000},"source":"Crossref","is-referenced-by-count":0,"title":["IgA binding characteristics of golden hamster and ferret Fc\u03b1 receptors"],"prefix":"10.1093","volume":"215","author":[{"given":"Xiaoxuan","family":"Ge","sequence":"first","affiliation":[{"name":"Thayer School of Engineering, Dartmouth College , Hanover, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R","family":"Stoner","sequence":"additional","affiliation":[{"name":"Thayer School of Engineering, Dartmouth College , Hanover, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1054-0628","authenticated-orcid":false,"given":"Joshua A","family":"Weiner","sequence":"additional","affiliation":[{"name":"Thayer School of Engineering, Dartmouth College , Hanover, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah S","family":"Parigela","sequence":"additional","affiliation":[{"name":"Thayer School of Engineering, Dartmouth College , Hanover, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanee E","family":"Balderas Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Thayer School of Engineering, Dartmouth College , Hanover, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor","family":"Taher","sequence":"additional","affiliation":[{"name":"The COBRE Institute for Biomolecular Targeting, Dartmouth College , Hanover, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwon","family":"Lee","sequence":"additional","affiliation":[{"name":"Thayer School of Engineering, Dartmouth College , Hanover, NH,","place":["United States"]},{"name":"Department of Convergence Medicine, Korea University College of Medicine , Seoul,","place":["Republic of Korea"]},{"name":"Vaccine Innovation Center, Korea University College of Medicine , Seoul,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4253-3476","authenticated-orcid":false,"given":"Margaret E","family":"Ackerman","sequence":"additional","affiliation":[{"name":"Thayer School of Engineering, Dartmouth College , Hanover, NH,","place":["United States"]},{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Dartmouth College , Hanover, NH,","place":["United 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